A5031064768- Pregnancy-related medical research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Occupational Health and Performance
- Cardiovascular Disease and Adiposity
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Liver Disease Diagnosis and Treatment
- Corrosion Behavior and Inhibition
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Electrodeposition and Electroless Coatings
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Electrospun Nanofibers in Biomedical Applications
- Injury Epidemiology and Prevention
- Hydrogen embrittlement and corrosion behaviors in metals
- Eicosanoids and Hypertension Pharmacology
- Natural product bioactivities and synthesis
Centro de Investigación Biomédica en Red
2019-2025
Instituto de Salud Carlos III
2019-2025
Complejo Hospitalario Universitario de Santiago
2017-2025
Complexo Hospitalario Universitario A Coruña
2024-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2019-2024
Instituto de Investigación Sanitaria de Santiago
2017-2024
Servicio Gallego de Salud
2018-2024
Centre for Biomedical Network Research on Rare Diseases
2022-2023
Abstract Background and Aims Meteorin‐like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated heart failure (HF), although contradictory results. Our aim was ascertain whether this could estimate the prognosis of HF de novo (DNHF) patients. Methods Metrnl plasma 400 hospitalized DNHF (55% reduced ejection fraction, 17.3% mid‐range 27.8% preserved fraction) were measured by...
Injectable and biocompatible novel hybrid hydrogels based on physically crosslinked natural biopolymers green graphene for potential use in tissue engineering are reported. Kappa iota carrageenan, locust bean gum gelatin used as biopolymeric matrix. The effect of content the swelling behavior, mechanical properties biocompatibility is investigated. present a porous network with three-dimensionally interconnected microstructures, lower pore size than that hydrogel without graphene. addition...
The pharmacological inhibition of sodium-glucose cotransporter 2 (SGLT2) has emerged as a treatment for patients with type diabetes mellitus (T2DM), cardiovascular disease and/or other metabolic disturbances, although some the mechanisms implicated in their beneficial effects are unknown. SGLT2 inhibitor (SGLT2i) empagliflozin been suggested regulator adiposity, energy metabolism, and systemic inflammation adipose tissue. aim our study was to evaluate impact 6-week-empagliflozin on lipidome...
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several diseases (CVD). Considering these effects, together the influence of on adipocyte physiology and adipokine secretion, connection between visceral adipose tissue (VAT) dysfunction development CVD, we could hypothesize that may regulate VAT metabolism. Our objective was to evaluate impact 2-week...
Atrial fibrillation is the most prevalent tachyarrhythmia in clinical practice, with very high cardiovascular morbidity and mortality a high-cost impact health systems. Currently, it one of main causes stroke subsequent heart failure sudden death. miRNAs mediate several processes involved disease, including fibrosis electrical structural remodeling. Several studies suggest key role course maintenance atrial fibrillation. In our study, we aimed to identify differential expression circulating...
Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation fibrosis pivotal processes pathogenesis of AF, our aim was to study relationship between relaxin-2 plasma levels left atrium (LA) peripheral vein with molecules implicated fibrosis, oxidative stress AF patients, evaluate anti-fibrotic ability normal human cardiac...
Relaxin is an insulin-like hormone with pleiotropic protective effects in several organs, including the liver. We aimed to characterize its role control of hepatic metabolism healthy rats. Sprague-Dawley rats were treated human recombinant relaxin-2 for 2 weeks. The metabolic profile was analyzed using UHPLC-MS platforms. Hepatic gene expression key enzymes desaturation (Fads1/Fads2) n-6 and n-3 polyunsaturated fatty acids (PUFAs), phosphatidylethanolamine (PE) N-methyltransferase (Pemt),...
The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter (SGLT2) inhibitors for treatment diabetes and cardiovascular disease. Recent evidences have shown benefits SGLT2 inhibitor empagliflozin on improving liver steatosis fibrosis T2DM. Metabolomic studies been to be very useful improve understanding pathophysiology during development progression metabolic hepatic...
Despite the reduction of cardiovascular events, including risk death, associated with sodium/glucose cotransporter 2 inhibitors (SGLT2i), their basic action remains unclear. Sodium/hydrogen exchanger (NHE) has been proposed as mechanism action, but there are controversies related to its function and expression in heart failure (HF). We hypothesized that sodium transported-related molecules could be altered HF modulated through SGLT2i. Transcriptome alterations genes involved transport were...
Atrial fibrillation (AF) is the most common arrhythmia worldwide, affecting 1% of population over 60 years old. The incidence and prevalence AF are increasing globally, representing a relevant health problem, suggesting that more advanced strategies for predicting risk stage highly needed. miRNAs mediate several processes involved in AF. Our aim was to identify with prognostic value as biomarkers patients referred ablation its association LVA extent, based on low-voltage area (LVA) maps. In...
Abstract Introduction Meteorin-like (metrnl), a new adipokine with insulin-sensitizing and anti-inflammatory action, has recently drawn much attention due to its protective effects in the cardiovascular system. Metrnl promotes heart repair after insults like ischemia/reperfusion, cardiotoxicity, or diabetic cardiomyopathy mice, circulating levels patients have been associated presence severity of coronary artery disease failure, although latter contradictory results. Purpose Our aim was...
Relaxin is a pleiotropic hormone included in the insulin-like-growth factor family (IGF) that produced variety of reproductive tissues including corpus luteum, uterus, testis, prostate and others.Relaxin facilitates parturition, participates uterine contractility, promotes angiogenesis, plays role spermatogenesis or spermatozoa motility acrosome reaction, among others physiological functions.In this review, we will focus on principal roles relaxin female male reproduction.
Ischemic cardiomyopathy (ICM) is associated with abnormal microRNA expression levels that involve an altered gene profile. However, little known about the underlying causes of disruption in ICM and whether maturation compromised. Therefore, we focused on defects analysis implication biogenesis pathway redox-sensitive microRNAs (redoximiRs). Transcriptomic changes were investigated via ncRNA-seq (ICM, n = 22; controls, 8) mRNA-seq 13; control, 10). The effect hypoxia was evaluated AC16 cell...
In this work, physically crosslinked injectable hydrogels based on carrageenan, locust bean gum, and gelatin, mechanically nano-reinforced with green graphene oxide (GO), were developed to address the challenge of finding materials a good balance between injectability mechanical properties. The effect GO content rheological properties, injectability, swelling behavior, biocompatibility nanocomposite was studied. hydrogels' morphology, assessed by FE-SEM, showed homogeneous porous...
Abstract EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial) trial highlighted the relevance of pharmacological inhibition sodium-glucose cotransporter 2 (SGLT2) for treatment patients with type diabetes mellitus (T2DM) and/or cardiovascular disease. Although pathways through which SGLT2 inhibitors exert a beneficial effect on system are still unknown, it has been suggested that energy metabolism regulation and reduction systemic inflammation could be some mechanisms...