A5062227198- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Nasal Surgery and Airway Studies
- Infection Control and Ventilation
- Airway Management and Intubation Techniques
- Renal and related cancers
- Head and Neck Surgical Oncology
- Genetic and Kidney Cyst Diseases
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Iron Metabolism and Disorders
- Advances in Oncology and Radiotherapy
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Ear and Head Tumors
- Folate and B Vitamins Research
- Meningioma and schwannoma management
- Cystic Fibrosis Research Advances
- Cleft Lip and Palate Research
- Bone Tumor Diagnosis and Treatments
- Gestational Trophoblastic Disease Studies
- Telemedicine and Telehealth Implementation
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Olfactory and Sensory Function Studies
Oregon Health & Science University
2024
University of Pittsburgh Medical Center
2020-2023
Children's Hospital of Pittsburgh
2020-2021
Eye and Ear Foundation
2021
University of California, Los Angeles
2015-2020
Baylor College of Medicine
2017-2018
University of California System
2015
Abstract Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, survivorship. Virtual MDC allows for improved collaboration between providers at distant sites proper allocation health resources in a time crisis. When approached systematically, virtual is feasible to design implement large academic medical center with multiple satellite hospitals.
Outside of SINUS-24 (A Controlled Clinical Study Dupilumab in Patients With Bilateral Nasal Polyps) and SINUS-52 (Controlled Polyps), there are limited data on the efficacy dupilumab patients with chronic rhinosinusitis nasal polyps (CRSwNP). The objective was to compare functional endoscopic sinus surgery (FESS) CRSwNP by assessing change polyp Sino-Nasal Outcome Test (SNOT-22) scores postintervention.A retrospective matched cohort study compared 54 who had treated FESS; both cohorts were...
Short-rib polydactyly syndromes (SRPS) arise from mutations in genes involved retrograde intraflagellar transport (IFT) and basal body homeostasis, which are critical for cilia assembly function. Recently, WDR34 or WDR60 (candidate dynein intermediate chains) were identified SRPS. We have characterized Tctex1d2, associates with Wdr34, Wdr60 other complex 1 2 subunits. Tctex1d2 localize to the base of cilium their depletion causes defects ciliogenesis. propose that is a novel light chain...
Objective To define the aerosol and droplet risks associated with endonasal drilling to identify mitigation strategies. Study Design Simulation series fluorescent 3-dimensional (3D) printed sinonasal models deidentified cadaveric heads. Settings Dedicated surgical laboratory. Subjects Methods Cadaveric specimens irrigated tracer 3D-printed were drilled. A cascade impactor was used collect aerosols small droplets of various aerodynamic diameters under 15 µm. Large generation measured by...
Objective: During the COVID-19 era, a reliable method for tracing aerosols and droplets generated during otolaryngology procedures is needed to accurately assess contamination risk develop mitigation measures. Prior studies have not investigated reliability of different fluorescent tracers purpose studying small droplets. Objectives include (1) comparing vitamin B2, fluorescein, commercial green dye in terms particle dispersion pattern, suspension into droplets, fluorescence aerosolized form...
Abstract Objective This project compares the degree of tracheal collapse determined by rigid and flexible bronchoscopy in paediatric patients with tracheomalacia. Methods A total nine tracheomalacia underwent both video bronchoscopy. All were breathing spontaneously. Cross-sectional images airway processed using ImageJ program analysed via colour histogram mode technique order to delineate luminal area. Paired t -tests (conducted Stata software version 13.0) quantified differences between...
To analyze trends in otolaryngology consultations and provide algorithms to guide management during the COVID-19 pandemic.A retrospective cohort study at a single institution tertiary care hospital. A total of 95 were performed from March 1, 2020 April 26, (COVID-era) 363 September 2019 February 29, (pre-COVID-era) UPMC Oakland campus. Data collected included patient demographics, status, reason for consult, location type procedures performed, need surgical intervention, length hospital stay...
Abstract Tracheostomy procedures have a high risk of aerosol generation. Airway providers reflected on ways to mitigate the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission risks when approaching surgical airway. To standardize institutional safety measures with tracheostomy, we advocate using dedicated tracheostomy time‐out applicable all patients including those suspected having COVID‐19. The aim is reduce preventable errors that may increase SARS‐CoV‐2.
Post-tracheotomy swallowing function has not been well described in the pediatric population. This study aims to (1) determine differences functioning pre- and post-tracheotomy (2) examine association between postoperative dysphagia indication for tracheotomy, age at time of tracheotomy modified barium swallow (MBS).A retrospective chart review was performed on 752 patients who underwent a from 2003 2018 had adequate documentation review. Patients were included if they received...
Somatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinson's disease. Lactotransferrin (LTF) is a member family transferrin binding proteins regulate homeostasis, increased levels LTF its receptor observed in neurodegenerative disorders like Here, we report binds ubiquitylates influence homeostasis. Parkin-dependent ubiquitylation occurred most often on lysines (K) 182 649. Substitution K182 or K649 with...
Objective (1) Review a multidisciplinary vascular anomalies center's practice regarding periprocedural anticoagulation for venous malformations (VM) and the associated risk of thromboembolic disseminated intravascular coagulation (DIC) events. (2) Compare events DIC post‐procedure between head neck (H&N) extremity VM patients. Methods An Institutional Board (IRB)‐approved, retrospective chart review was performed on 120 A event defined as thrombus formation post‐sclerotherapy or...
Hypothesis: Aerosols are generated during mastoidectomy and mitigation strategies may effectively reduce aerosol spread. Background: An objective understanding of generation the effectiveness can inform interventions to risk from other open surgeries involving drilling. Methods: Cadaveric fluorescent three-dimensional printed temporal bone models were drilled under variable conditions methods. Aerosol production was measured with a cascade impactor set detect particle sizes 14.1 μm. Field...
Objectives: Define aerosol and droplet risks associated with routine otolaryngology clinic procedures during the COVID-19 era. Methods: Clinical were simulated in cadaveric heads whose oral nasal cavities coated fluorescent tracer (vitamin B2) breathing was manually through retrograde intubation. A cascade impactor placed adjacent to nares collected generated particles aerodynamic diameters ≤14.1 µm. The 3D printed models syringes used simulate middle external ear suctioning as well open...
Abstract Objectives The aim of this study was to determine the clinical characteristics and cephalometric risk factors associated with decreased postoperative olfaction in patients whom transplanum transtuberculum expanded endonasal approach (EEA) performed. Methods A retrospective cohort 41 treated EEA divided into two groups based on maximum change 22-item Sino-Nasal Outcome Test (SNOT22) score: prolonged olfactory loss group (n = 5) a ΔSNOT22 score ≥ 4 without return baseline preserved...
ABSTRACT Somatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinson’s disease. Lactotransferrin is a member transferrin binding proteins regulate increased levels its receptor observed in neurodegenerative disorders like Here, we report binds ubiquitylates it homeostasis.
Introduction: Patients who undergo transplanum or transtuberculum expanded endonasal approaches (EEA) may be at higher risk of developing postoperative olfactory dysfunction given the proximity to posterior cleft. The objective was determine clinical characteristics and cephalometric factors associated with decreased post-operative olfaction for EEA patients.