A5076973404- Synthesis of Indole Derivatives
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Chemical Reaction Mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Enzyme Catalysis and Immobilization
- Photochromic and Fluorescence Chemistry
- Synthesis of Organic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biofuel production and bioconversion
- Free Radicals and Antioxidants
- Photochemistry and Electron Transfer Studies
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Reactions and Mechanisms
- PARP inhibition in cancer therapy
- Malaria Research and Control
- Asymmetric Hydrogenation and Catalysis
Bidhan Chandra Krishi Viswavidyalaya
2024
Central Drug Research Institute
2017-2023
Banaras Hindu University
2022-2023
Academy of Scientific and Innovative Research
2020
University of Lucknow
2020
Abstract There has recently been an increased interest in active pharmaceutical agents and various other molecules that contain the 1, 1‐diaryl stereocenter. This led to development of novel synthetic strategies access having this structural moiety. The current Review describes variety methodologies available for enantioselective synthesis 1‐diarylethanes, triarylmethanes related with a stereogenic center were reported since 1995. prime focus is on formation 1‐diarylmethine stereocenter...
A selection of aromatic amines has been shown to react with pentyl nitrite in the presence bromoform give corresponding aryl bromides acceptable yield. Corresponding reactions bromotrichloromethane, chloroform, and carbon tetrachloride have proved be synthetically less useful.
An expeditious, cost-effective synthetic methodology for a wide range of nitrogen-containing unsymmetrical trisubstituted methanes (TRSMs) is reported. The synthesis involves base-mediated 1,6-conjugate addition heterocyclic amines and amides to substituted para-quinone methides, giving the TRSMs in moderate very good yields (up 83%) one pot. low cost, mild temperature, high atom economy yields, easy scale-up broad substrate scope are some salient features this protocol. Further, could be...
A scalable and eco-friendly total synthesis of PARP inhibitor.
A transition-metal free, proficient strategy for the one-pot synthesis of diverse diaryl methyl amino acid esters (DMAAEs) has been established from easily accessible chiral and <italic>para</italic>-quinone methides (QMs) in very good to excellent yields.
Abstract A small focused library of diarylmethyl amines were synthesized through base mediated 1,6‐addition heterocyclic and amides with p ‐quinone methides tested for their antibacterial potential against ESKAPE bacterial pathogen panel. Some the compounds exhibited potent activity Gram‐positive bacteria in addition to being non‐cytotoxic eukaryotic cells. Careful analysis structure–activity‐relationships (SARs) projected revealed two important entities necessary exhibit (a nitrogenous a...
Coumarins are noteworthy due to their widespread usage as materials and biological agents in various applications. Despite the fact that this molecule is known for a very long time, its possible new derivatives have not yet been thoroughly investigated. This paper described an efficient one-pot synthesis of novel 2-Arylbenzo[f]coumarinderivatives optical properties. It revealed even small modification can extensively change photophysical vibrational
Tri and Tetra-substituted Methanes (TRSMs) are a significant structural motif in many approved drugs prodrugs. There is increasing use of TRSM units medicinal chemistry, derivatives specifically designed to make drug-target interactions through new chemical space around moiety. In this perspective, we describe synthetic challenges for accessing range functionalized selective TRSMs their molecular mechanism action, especially as anti-infectives. Natural anti-infectives like (+)-Bionectin A,...