A5040125670- RNA Research and Splicing
- 14-3-3 protein interactions
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Toxin Mechanisms and Immunotoxins
Southwestern Medical Center
2024
The University of Texas Southwestern Medical Center
2019-2024
Howard Hughes Medical Institute
2019
ATP-grasp superfamily enzymes contain a hand-like ATP-binding fold and catalyze variety of reactions using similar catalytic mechanism. More than 30 protein families are categorized in this superfamily, they involved plethora cellular processes human diseases. Here, we identify C12orf29 (RLIG1) as an atypical enzyme that ligates RNA. Human RLIG1 its homologs autoadenylate on active site Lys residue part reaction intermediate specifically RNA halves containing 5’-phosphate 3’-hydroxyl. binds...
Abstract ATP-grasp superfamily enzymes contain a hand-like ATP-binding fold and catalyze variety of reactions using similar catalytic mechanism. More than 30 protein families are categorized in this superfamily, they involved plethora cellular processes human diseases. Here we identify C12orf29 as an atypical enzyme that ligates RNA. Human its homologs auto-adenylate on active site Lys residue part reaction intermediate specifically RNA halves containing 5’-phosphate 3’-hydroxyl. binds tRNA...