A5101799755- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Cardiac Fibrosis and Remodeling
- Alzheimer's disease research and treatments
- Kruppel-like factors research
- Botulinum Toxin and Related Neurological Disorders
- Venous Thromboembolism Diagnosis and Management
- Lymphadenopathy Diagnosis and Analysis
- Cardiovascular Health and Disease Prevention
- Neurological disorders and treatments
- Gout, Hyperuricemia, Uric Acid
- Tumors and Oncological Cases
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Nuclear Receptors and Signaling
Ehime University
2014-2015
Osaka University
2011-2013
Kure Medical Center
2010
Fukuoka City Hospital
2010
Progranulin (PGRN) is a multifunctional protein known to be involved in inflammation. However, the relation between PGRN and atherosclerosis remains elusive. The aim of this study was define role development atherosclerosis.First, we checked expression levels human atherosclerotic plaques. Immunohistochemical analysis showed that strongly expressed foam cells We also found more abundantly macrophages than smooth muscle lesions ApoE(-/-) mice fed high-fat diet for 12 weeks. Next,...
Postprandial hyperlipidemia (PH) is thought to be caused by the impaired postprandial metabolism of triglycerides (TG)-rich lipoproteins in both endogenous and exogenous pathways; however, there no consensus. It difficult estimate presence PH without performing a time-consuming oral fat loading (OFL) test, so lipoprotein was analyzed measuring levels apolipoprotein (apo) B-48 apo B-100, correlation between TG increase fasting apoB-48 assessed establish good marker an OFL test.Ten male...
The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL transporter long-chain fatty acids. Because uptake in CD36-deficient macrophages results CD36 knockout mice, deficiency (CD36-D) was supposed to be associated with reduced risks coronary artery disease (CAD); however, CD36-D patients are often accompanied by risk factors. current study...
Atherosclerotic lesions of the coronary arteries are pathological basis for myocardial infarction and ischemic cardiomyopathy. Progression heart failure after is associated with cardiac remodeling, which has been studied by means ligation in mice. However, this model requires excellent techniques. Recently, a new murine model, HypoE mouse was reported to exhibit atherogenic Paigen diet-induced atherosclerosis infarction; however, mice died too early make possible investigation remodeling....
Aim: Remnant lipoproteins are atherogenic and accumulated in patients with type III hyperlipidemia (HL). Although HL is diagnosed by phenotyping apolipoprotein (apo) E, this procedure time-consuming inconvenient for routine clinical use. Clinical indices screening untreated have been proposed; however, settings, promptly treated lipid-lowering agents without diagnosing the underlying cause. We investigated whether existing as well apo B-48/triglyceride (TG) ratio, which was suggested to be...
Objective Metabolic syndrome (MetS) and decreased adiponectin level have been reported to be clinically associated with type 2 diabetes mellitus coronary artery disease (CAD). However, it has not fully defined whether they are the severity of CAD, independent hyperglycemia. In current study, we investigated clinical relationship between serum MetS, its association CAD in patients good glycemic control. Patients Methods this enrolled 97 subjects an HbA1c concentration <7.0% (5.5±0.6%), who...
Objectives: Atherosclerotic lesions of the coronary arteries are pathological basis for myocardial infarction and ischemic cardiomyopathy.Progression heart failure after is associated with cardiac remodeling, which has been studied by means ligation in mice.However, this model requires excellent techniques.Recently, a new murine model, HypoE mouse was reported to exhibit atherogenic Paigen diet-induced atherosclerosis infarction; however, mice died too early make possible investigation...
症例は35歳女性である．母に関節リウマチ，妹にシェーグレン症候群がある．1年半の間にリンパ節腫張にひき続く無菌性髄膜炎を3回くりかえした．3回目で頸部リンパ節生検をおこない亜急性壊死性リンパ節炎の所見をえた．非ステロイド系消炎鎮痛薬に対する反応は不良であったが，ステロイド投与後に発熱，頭痛，リンパ節腫張はすみやかに改善した．初回入院時から抗核抗体，抗SS-A抗体陽性は持続しており，とくに抗核抗体は再発の度に抗体価が上昇した．亜急性壊死性リンパ節炎は一般的に数カ月以内に自然治癒する予後良好な疾患で，自己抗体の出現も一過性が多い．本例のように無菌性髄膜炎をくりかえすばあいには，自己免疫異常の持続が一因と考えられる．
要旨：症例は53 歳男性，右上肢の感覚障害と脱力発作を繰り返し，脳梗塞を指摘され入院した．本態性血小板血症と診断され，JAK2 遺伝子変異を有した．入院後も右上肢の脱力症状を繰り返し，急性期には低容量アスピリンと抗凝固薬の併用を要したが，骨髄抑制療法の効果発現後にはアスピリンが中止可能となった．JAK2 遺伝子変異陽性例では，血小板数や機能の異常のみでなく，凝固因子の異常や血管内皮の機能障害を認めることが指摘されており，高齢，血栓塞栓症の既往などに加えて，本態性血小板血症における血栓塞栓症のリスク因子の一つであるといわれる．本症例はアテローム血栓性脳梗塞に類似した臨床経過を呈し，血管内皮の機能障害を背景とした血管壁の血栓易形成性が，脳梗塞発症に関連している可能性を推測した．本疾患における最適な抗血栓療法を検討する上で貴重な症例であると考えられ，報告する．
症例は40歳，男性で，頭痛，嘔吐を主訴に救急搬送された．性転換術による精巣摘出の既往があり，来院1カ月前から女性化目的に経口避妊薬を内服していた．来院時の神経学的所見では，軽度の意識障害のみで局所徴候はなかった．血液検査では凝固系の亢進があり，頭部CTでは直静脈洞，上矢状静脈洞，左横静脈洞に高吸収域を認めた．MRVでは左横静脈洞の信号消失と右横静脈洞の信号低下があり，脳静脈洞血栓症と診断した．抗凝固療法を開始し，経過中に出血性梗塞を来したものの，再開通を得た．静脈血栓症の原因として経口避妊薬は知られているが，今回はさらにアンドロゲン低下による線維素溶解能の低下が素地にあったものと考えられた．