A5050176618- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Pregnancy and preeclampsia studies
- Ophthalmology and Visual Impairment Studies
- Tracheal and airway disorders
- Connexins and lens biology
- Thyroid and Parathyroid Surgery
- Head and Neck Cancer Studies
- Biomedical and Engineering Education
- Preterm Birth and Chorioamnionitis
- Tea Polyphenols and Effects
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Flavonoids in Medical Research
- Ocular Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Prenatal Screening and Diagnostics
- Retinal and Macular Surgery
- Gout, Hyperuricemia, Uric Acid
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive System and Pregnancy
University of Electronic Science and Technology of China
2018-2025
Shanghai Electric (China)
2025
Guangdong Academy of Medical Sciences
2010-2024
Ministry of Agriculture and Rural Affairs
2024
Southern Medical University
2010-2024
Guangdong Provincial People's Hospital
2019-2024
Jimei University
2024
China University of Petroleum, East China
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Abstract Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green extract its catechin constituents ameliorate sodium iodate-induced retinal degeneration rats by counteracting oxidative stress. In this study, adult Sprague-Dawley were intravenously injected with a single dose of iodate. (GTE; Theaphenon-E) or combinations constituents, including (−)-epigallocatechin gallate (EGCG), administered intra-gastrically...
Significance We have shown that the growth hormone-releasing hormone–growth hormone–insulin-like factor-1 (GHRH–GH–IGF1) axis is involved in experimentally induced acute inflammation iris and ciliary body, where its activation associated with inflammatory responses. Blocking GHRH–GH–IGF1 activity by GHRH receptor (GHRH-R) antagonist effective alleviating These findings demonstrate a novel of signaling ocular suggest potential therapeutic application GHRH-R antagonist.
Significance Emerging evidence indicates that the receptor for growth-hormone–releasing hormone (GHRH-R) is involved in a wide spectrum of extra-pituitary activities, including tumor growth and inflammation. This study elucidates molecular mechanism inflammatory processes acute ocular inflammation mediated by GHRH-R. In human ciliary epithelial cells, expression GHRH-R gene elevated after lipopolysaccharide insult through phosphorylation NF-κB. The activation stimulates activity JAK2/STAT3...
Abstract Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated senescence of lens epithelial cells (LECs), leading to cataract progression. To better understand underlying mechanisms, we investigated UA-driven human tissue samples obtained during surgery, rat organ cultures, and vivo experiments, using senescence-associated β-galactosidase (SA-β-gal) staining, electronic microscopy, Western blotting,...
Abstract Importance: Glaucoma is one of the world's leading causes irreversible blindness and effective interventions with less side effect cost were still in need. Objective: To investigate potential repurposing antihypertensive drugs to glaucoma treatment intra ocular pressure (IOP) lowering manners. Design, Setting Participants: Two sample Mendelian Randomization (MR) was used genetic on protection or IOP lowering. strategies (biomarker eQTL approach) applied define instrumental variable...
Purpose: To report a case of long-term postoperative vitreous hemorrhage (PVH) proliferative diabetic retinopathy after pars plana vitrectomy (PPV), which is most likely to be associated with neovascularization (NV) formed at the incision site vitrectomy, and recommend better surgical technique for diagnosis treatment such patients. Methods: Intraoperative fundus fluorescein angiography (FA) was performed using customized intraoperative blue light excitation source observed by...
The structural stability of transmission towers critically depends on the integrity bolted connections, necessitating accurate bolt loosening detection for power grid safety. Traditional methods, such as manual inspection and hammering-based auditory analysis, suffer from inefficiency inaccuracy due to environmental noise subjective judgment. This paper proposes a novel machine learning framework intelligent using acoustic signature analysis. integrates multi-channel data strategically...
Abstract Objective Pseudophakic malignant glaucoma (PMG) is an uncommon but severe postoperative complication that poses a significant threat to vision. Early detection of PMG in patients with primary angle closure (PACG) imperative for effective intervention. This study sought determine whether specific morphometric indicators could predict the onset PMG. Methods A retrospective cross-sectional analysis was performed on data collected from June 2016 May 2023. The population comprised PACG...
Green tea extract (GTE) ingested by rats exerted anti-oxidative activities in various ocular tissues as shown our previous studies. The present work investigated anti-inflammatory effects of GTE on endotoxin-induced uveitis (EIU). EIU was generated adult a footpad injection 1 mg/kg lipopolysaccharide (LPS). Oral administration (550 mg/kg) given one, two or four times after LPS injection. Twenty-four hours later, produced severe hyperemia and edema the iris. Immunocytochemical examinations...
To determine the relationship between gestational age and ultrasonic measurement of umbilical coiling index (UCI), to assess ability second-trimester measurements UCI predict true UCI, determined at birth.Five hundred thirty-one consecutive women with uncomplicated pregnancies, booking for delivery a singleton pregnancy, were recruited during routine fetal morphology scan. Multiple ultrasonographic intercoil distance performed two three coils cord, along its entire visible length. Three...
AIM: To investigate the role of microRNA-34a (miR-34a) in induction apoptosis human lens epithelial (HLE-B3) cells. METHODS: The HLE-B3 cells was detected by Annexin V-PE detection kit after treatment with 200 μmol/L H2O2 for 24h and lentiviral miR-34a vector transfection. expression quantified quantitative real time polymerase chain reaction (qRT-PCR) response to exposure effects overexpression on B-cell lymphoma-2 (Bcl-2) silent information regulator 1 (SIRT1) determined qRT-PCR Western...
Abstract Objective To compare the accuracy of intrapartum ultrasound with and without color Doppler for identification nuchal cord displacement during labor. Methods 180 normal pregnant women, admitted in labor, or induction to were examined independently by two researchers, using either conventional real‐time gray‐scale imaging imaging. A repeat examination was performed other researcher modality. Nuchal classified as negative, definite suspicious. at birth tight loose. Results Sixty‐two...
Significance Optic neuropathies, characterized by the degeneration of retinal ganglion cells (RGCs) and their axons, are leading causes irreversible blindness visual impairment, for which currently there is no effective treatment or cure. This study demonstrates that subcutaneous application an agonist antagonist growth hormone–releasing hormone (GHRH) reduces RGCs induced optic nerve injury in rats. GHRH further enhances neuroprotective effect macrophage activation on survival RGCs. Our...
Purpose. To compare the efficacy of subthreshold and conventional selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) patients with primary open-angle glaucoma (POAG). Methods. Fifty-two eyes from fifty-two POAG were randomized into two groups, one group treated SLT using two-thirds energy other energy. IOP was measured Goldmann tonometer anterior chamber inflammation determined flare meter. Results. The initial dosage used significantly lower than amount (<mml:math...
Age-related cataract is the leading cause of blindness worldwide. The pathological mechanisms causing this disease remain elusive.To examine involvement uric acid (UA) in pathogenesis posterior subcapsular (PSC).Retrospective study and experimental investigation.A total 180 patients with PSC or non-PSC were included.Samples obtained from used to analyse content UA for histochemical examinations. effects on human lens epithelial cells also investigated.Aqueous humour urate deposits.The...