A5064409646- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Alcoholism and Thiamine Deficiency
- Vagus Nerve Stimulation Research
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Phosphodiesterase function and regulation
- Cancer-related molecular mechanisms research
- Neurological disorders and treatments
- Medicinal Plants and Neuroprotection
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Transcranial Magnetic Stimulation Studies
- Protein Interaction Studies and Fluorescence Analysis
Aligarh Muslim University
2024
Shoolini University
2018-2024
Jawaharlal Nehru Medical College Hospital
2024
Indian Veterinary Research Institute
2020
Alzheimer's disease (AD) poses significant health challenges for the elderly due to its complex origins and heterogeneous etiology. Currently, there are no medications specifically aimed at halting progression through any preventive signaling mechanism. Therefore, is a pressing need explore alternative pathways that could guide researchers towards new avenues in drug development managing AD sustainability. This article first simultaneously review several potential were previously reported as...
Where Alzheimer's disease (AD) is becoming a global health issue, the present anti-AD medications have also been exposed to produce only symptomatic outcomes. The pathological factors, like neuronal transmission impairment, amyloidal-tau constituents, oxidative damage, neuro-inflammation, synaptic dysfunction, infectious agents, and impairment of gut microbiota vitamins' levels; all favor disease's progression sustainability. researchers investigated several drugable molecules against these...
β-amyloid (Aβ) production and aggregation are the main culprits of Alzheimer's disease (AD). There is no treatment available for halting progression. Antibiotics used not only to treat infections but also some non-contagious diseases have found active as anti-amyloidogenic agents.The aim this work investigate activity antibiotics repurposing agents via inhibiting Aβ fibril formation employing in silico vitro approaches.In screening was designed with receptor ligand preparation, grid...
Pinus roxburghii Sarg. is traditionally used as a nerve tonic, hemostatic and anticonvulsant. The present study was aimed to investigate the neuroprotective activity of roxburghiiSarg. stem bark for memory cognition using in vitro vivo methods. Plant drug extracted with methanol Soxhlet extraction. In cell viability assessed PC-12 lines. tested on Wistar albino rats (either sex) intracerebroventricular streptozotocin (3 mg/kg, bilateral) given cause deficits. High-performance thin layer...
MicroRNAs (miRNAs) are pivotal regulatory molecules involved in numerous cellular processes, including apoptosis, differentiation, proliferation, and migration. Recent research highlights specific miRNAs, such as the miR-221/222 cluster, which modulate key signaling pathways related to vascular smooth muscle cell (VSMC) inflammation, endothelial function. This function of is accompanied by influencing expression certain proteins implicated VSMCs cells processes. miRNAs have been increasingly...