A5100693374- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Bone Metabolism and Diseases
- Phytochemicals and Medicinal Plants
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Natural Antidiabetic Agents Studies
- Phytochemistry and Bioactive Compounds
- Renin-Angiotensin System Studies
- Neurotransmitter Receptor Influence on Behavior
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Neurological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Bone health and osteoporosis research
- Phytochemical Studies and Bioactivities
- TGF-β signaling in diseases
- Polysaccharides and Plant Cell Walls
- Berberine and alkaloids research
- Histone Deacetylase Inhibitors Research
- Sesame and Sesamin Research
Shoolini University
2015-2024
Alberta Children's Hospital
2023
Institute of Life Sciences
2022
Dr. Rajendra Prasad Government Medical College
2011
Background: Traditionally, Pine has been used to treat oxidative and inflammatory disorders.The study was aimed investigate biological potential of phytoconstituents Pinus plant species: roxburghii, wallichiana gerardiana using in-vitro antioxidant, anti-inflammatory antimicrobial methods. Method:The hydro-alcoholic extraction dried plant: stem bark done the antioxidant activity evaluated free radical scavenging methods for 1,1-diphenyl-2-picrylhydrazyl, (DPPH), nitric oxide hydrogen...
Protein kinase C (PKC) is a diverse enzyme family crucial for cell signalling in various organs. Its dysregulation linked to numerous diseases, including cancer, cardiovascular disorders, and neurological problems. In the brain, PKC plays pivotal roles synaptic plasticity, learning, memory, neuronal survival. Specifically, PKC’s involvement Alzheimer’s Disease (AD) pathogenesis of significant interest. The has been AD. This review elucidates role health, particularly its implications AD...
Bombax ceiba is used traditionally to treat bone disorders, rheumatism, and joint pain. The aim of the study carry out osteogenic activity in-vitro anti-osteoporotic in-vivo stem bark B. in surgical ovariectomy model female rats.Plant drug: was extracted with solvents petroleum ether methanol using Soxhlet extraction. In-vitro osteoblastic proliferation performed UMR-106 cell lines. Both extracts were undergone acute toxicity as per OECD423 guidelines. Female Wistar albino rats 180-240 g (n...
Huntington’s disease (HD) is a prototypical neurodegenerative disease, preferentially disrupting the neurons of striatum and cortex. Progressive motor dysfunctions, psychiatric disturbances, behavioral impairments, cognitive decline are clinical symptoms HD progression. The occurs due to expanded CAG repeats in exon 1 huntingtin protein (mHtt), causing its aggregation. Multiple cellular molecular pathways involved pathology. Mitochondria, as vital organelles have an important role most...
Background: Chebulinic acid (CA), a component in Terminalia chebula, exhibits antiulcer activity, but has poor aqueous solubility. Raft-forming systems incorporating solid dispersions (SDs) of CA, were developed to overcome its biopharmaceutical properties and prolong the gastric residence time for maximum activity. Methods: SDs formulated by solvent evaporation method using Eudragit EPO. Raft formulations consisted sodium alginate as polymer. Results: Release CA dissolution medium was 40%,...
The present study was aimed to explore the chemical composition and evaluate biological efficacy of needles stem bark oils three Pine plant species: Pinus roxburghii, P. wallichiana, gerardiana for oxidative, inflammatory infectious diseases. essential plants (needles bark) were obtained by hydrodistillation analyzed using GC/MS. further assessed antioxidant, anti-inflammatory, anti-microbial activities in-vitro. antimicrobial activity against four bacterial strains agar well diffusion test....
Abstract Background Alcohol abuse is a major problem worldwide and it affects people’s health economy. There relapse in alcohol intake due to withdrawal. withdrawal anxiety-like behavior symptom that appears 6–24 h after the last ingestion. Methods The present study was designed explore protective effect of standardized polyherbal preparation POL-6 ethanol anxiety Wistar rats. prepared by mixing dried extracts six plants Bacopa monnieri, Hypericum perforatum, Centella asiatica, Withania...
Bone is one of the dynamic tissues in human body that undergoes continuous remodelling through subsequent actions bone cells, osteoclasts, and osteoblasts. Several signal transduction pathways are involved transition mesenchymal stem cells into These primarily include Runx2, ATF4, Wnt signaling sympathetic signalling. The differentiation osteoclasts controlled by M-CSF, RANKL, costimulatory It well known regulated receptor activator nuclear factor-kappa B ligand followed binding to RANK,...
Abstract: The term “neurodegenerative disorders” refers to a group of illnesses in which deterioration nerve structure and function is prominent feature. Cognitive capacities such as memory decision-making deteriorate result neuronal damage. primary difficulty that remains safeguarding neurons since they do not proliferate or regenerate spontaneously are therefore substituted by the body after have been damaged. Millions individuals throughout world suffer from neurodegenerative diseases....
Abstract: Effective management of dyslipidemia is paramount importance to prevent cardiovascular (CV) complications. Using current clinical practice guidelines recommended correct lipid levels and further pathologic processes. This article presents an overview treatment options for patients with CV disease, a special focus on the following drug classes: HMG-CoA reductase inhibitors (also called statins), cholesterol absorption (ezetimibe), bile acid sequestrants, fibrates, icosapent ethyl,...
Pinus roxburghii Sarg. is traditionally used as a nerve tonic, hemostatic and anticonvulsant. The present study was aimed to investigate the neuroprotective activity of roxburghiiSarg. stem bark for memory cognition using in vitro vivo methods. Plant drug extracted with methanol Soxhlet extraction. In cell viability assessed PC-12 lines. tested on Wistar albino rats (either sex) intracerebroventricular streptozotocin (3 mg/kg, bilateral) given cause deficits. High-performance thin layer...
The study was aimed to evaluate the potential of hydroalcoholic extract Pinus roxburghii (PRE) stem bark in post-menopausal osteoporosis and its underlying mechanisms.In silico docking markers done using AutoDock version 4.2. for molecular targets: receptor activator nuclear factor-κB (RANK), osteoprotegerin (OPG) Cathepsin. Female Wistar rats bodyweight 200-250 g were employed surgical ovariectomy (OVX) performed. PRE administered at a dose 100 200 mg/kg whereas standard drug, raloxifene...