A5086523611- Adenosine and Purinergic Signaling
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Essential Oils and Antimicrobial Activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin C and Antioxidants Research
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Natural Antidiabetic Agents Studies
- Phytochemistry Medicinal Plant Applications
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 Impact on Reproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Insect behavior and control techniques
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Pineapple and bromelain studies
- Morinda citrifolia extract uses
- Bioactive Compounds and Antitumor Agents
- Diabetes and associated disorders
- Piperaceae Chemical and Biological Studies
Universidade Federal da Fronteira Sul
2020-2025
Universidade Federal de Santa Catarina
2023-2025
Abstract Cutaneous melanoma (CM) is a malignant neoplasm with high metastatic rate that shows poor response to systemic treatments in patients advanced stages. Recently, studies have highlighted the antineoplastic potential of natural compounds, such as polyphenols, adjuvant therapy context treat CM. The objective present study was evaluate effect different concentrations curcumin (0.1–100 µM) on CM cell line SK‐MEL‐28. cells were treated for 6 and 24 h curcumin. Cell viability assessed by...
The essential oil from Piper corcovadense D.DC. (EOPc), an important plant belonging to the Piperaceae family, which is commonly found in Northern region of Brazil and poorly explored scientifically, was used this study. Thus, EOPc characterized chemically by Gas Chromatography/Mass Spectrometry (GC/MS) antioxidant antimicrobial activities their potential effects on cutaneous melanoma (SK-MEL-28) healthy peripheral blood mononuclear (PBMC) cells were determined. major compounds identified...
<title>Abstract</title> Stress in childhood can harm brain development, leading to biological and systemic dysfunctions that, along with genetic factors, may contribute major depressive disorder (MDD) adulthood. MDD treatment is complex, current drugs taking time show effects not working for many patients. As a result, medicinal plants, like <italic>Aloysia citriodora</italic> (<italic>A. citriodora</italic>), are being studied as treatments resistant depression. The main objective of this...
Background/Objectives: Cutaneous melanoma (CM) poses a critical public health concern due to its high recurrence rates and resistance standard treatments. This study investigated the antineoplastic potential of Curcuma Longa L. extract enriched with Bisdemethoxycurcumin (AC3TM) on human cell lines A375 SK-MEL-28. Methods: The SK-MEL-28 were cultured according manufacturer&#039;s recommendations subsequently treated different concentrations AC3TM. MTT test fluorescence microscopy used...
This study aimed to evaluate whether the addition of a phytobiotic additive formulated based on cinnamon and oregano essential oils (50% free 50% microencapsulated) combined with turmeric extract tannins diet cows has beneficial effects health, productivity, milk quality. In completely randomized design, eighteen Jersey were used in compost barn system over 45 days. The divided into two homogeneous groups: one control (without additive; n = 9) another treatment (with at dose 2 g/cow/day; 9)....
Cutaneous melanoma is an aggressive type of skin cancer that recognized for its high metastatic potential and the challenges it presents in treatment. There has been increasing interest plant extracts their applications melanoma. The present study aimed to investigate content individual phenolic compounds araçá-boi extract, evaluate antioxidant activity, explore effects on cell viability, migration properties, oxidative stress levels, protein expression human line SK-MEL-28. HPLC-DAD...
<title>Abstract</title> Major depressive disorder (MDD) is a severe that causes enormous loss of quality life, and among the factors underlying MDD stress in maternal deprivation (MD). In addition, classic pharmacotherapy has presented adverse effects. <italic>Centella asiatica (C. asiatica) </italic>demonstrates potential neuroprotective but not yet been evaluated MD models. Objective: This study aimed to evaluate effect <italic>C. asiatica</italic>extract active compound madecassic acid on...
Achyrocline satureioides, a medicinal plant widely used in Brazilian traditional medicine for diverse healing applications, has been underexplored its potential anticancer properties. This study aimed to investigate the antitumor of A. satureioides extract on SK-Mel-28 melanoma cells, using an innovative approach devised by authors that involves potentiating solution iron dextran enhance efficacy bioactive and agents. The was characterized phytochemical composition, antioxidant effect,...