A5055567694- Fatty Acid Research and Health
- Diet and metabolism studies
- Coconut Research and Applications
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Phytochemistry Medicinal Plant Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Advanced Glycation End Products research
- Exercise and Physiological Responses
- Education Pedagogy and Practices
- Biochemical effects in animals
- Growth and nutrition in plants
- Children's Physical and Motor Development
- Rural and Ethnic Education
- Cardiovascular and exercise physiology
- Regulation of Appetite and Obesity
- Pineapple and bromelain studies
- Biochemical Analysis and Sensing Techniques
- Rural Development and Agriculture
- Nerve injury and regeneration
- Agricultural and Food Sciences
- Effects of Radiation Exposure
Universidade Federal da Fronteira Sul
2015-2022
Universidade Federal do Paraná
2004-2016
Abstract In this study we investigated the effect of lifelong supplementation diet with coconut oil (CO, rich in saturated fatty acids) or fish (FO, n-3 polyunsaturated acids, PUFAs) on tumor growth, animal survival, and metabolic indicators cachexia adult rats. Female Wistar rats were supplemented CO FO prior to mating then throughout pregnancy gestation, male offspring from weaning until 90 days age. Then they inoculated subcutaneously Walker 256 cells. Tumor weight at 14 control (those...
Obesity is commonly associated with diabetes, cardiovascular diseases and cancer. The purpose of this study was to determinate the effect a lower dose fish oil supplementation on insulin sensitivity, lipid profile, muscle metabolism in obese rats.Monosodium glutamate (MSG) (4 mg/g body weight) injected neonatal Wistar male rats. Three-month-old rats were divided normal-weight control group (C), coconut fat-treated normal weight (CO), oil-treated (FO), (Ob), (ObCO) (ObFO). Obese...
Fish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specifically α-linolenic fatty acid (ALA), controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), supplemented with FO or Oro Inca (OI), Walker 256 tumor-bearing (W), (WFO) OI (WOI). Rats were (1g/kg body weight/day) during 4 wk then the groups inoculated cells suspension 14 days later animals killed. WFO increased EPA fivefold DHA 1.5-fold tissue...
Several studies have been shown pro-apoptotic effects of fish oil (FO), rich in n-3 polyunsaturated fatty acids (n-3 PUFA) on cancer cells. Nevertheless, few vivo experiments provided data its ability apoptosis protein expression tumor tissue. Thus, this study we investigate the effect FO supplementation Walker 256 bearing rats. Male Wistar rats were randomly assigned to three groups: fed with regular chow (W); supplemented (WFO) or coconut fat (WCO) (1 g/kg body weight/daily). After thirty...
Abstract Abstract: In this study we investigate the impact of dietary ratio n-6 to n-3 fatty acids (FAs) from postweaning until adult age upon tumor growth, lipid peroxidation in tissue, and metabolic indicators cancer cachexia Walker 256 tumor-bearing rats. Weanling male Wistar rats received a normal low-fat (40 g/kg diet) chow diet or high-fat diets (300 g/kg) that included fish oil (FO) sunflower blends FO yield FA ratios approximately 6:1, 30:1, 60:1 ad libitum. After 8 wk, half each...
Background/Objectives: Glutamine plays a key role in immune response. Spinal cord injury (SCI) leads to severe loss of muscle mass and high incidence infections. This study investigated the acute effect SCI (2 5 days) on plasma glutamine skeletal concentrations responses rats.Methods: A total 29 adult male Wistar rats were divided as follows: control (C; n = 5), sham-operated (S2; 5) spinal cord-transected (T2; 7). They killed day 2 after surgery/transection (acute phase). Another set was...
Fish oil supplementation has been shown to improve the cachectic state of tumor-bearing animals and humans. Our previous study showed that fish (1 g per kg body weight day) for 2 generations had anticancer anticachetic effects in Walker 256 rats as demonstrated by reduced tumor growth loss increased food intake survival. In this study, effect on membrane integrity, proliferation capacity, CD4/CD8 ratio lymphocytes isolated from mesenteric lymph nodes, spleen, thymus was investigated. We also...
This study investigated the effect of interval training on blood biochemistry and immune parameters in type 1 diabetic rats.Male Wistar rats were divided into four groups: sedentary (SE, n = 15), (IT, 17), (DSE, (DIT, 17). Diabetes was induced by i.v. injection streptozotocin (60 mg/kg). Swimming Interval Training consisted 30-s exercise with rest, for 30 minutes, during 6 weeks, times a week, an overload 15% body mass. Plasma glucose, lactate, triacylglycerol total cholesterol...
Abstract The effect of coconut fat (rich in medium saturated fatty acids) or fish oil ω‐3 polyunsaturated supplementation for 2 generations on tumor growth, cancer cachexia, animal survival and macrophage function was investigated Walker 256 tumor‐bearing rats. Female Wistar rats were supplemented with prior to mating then throughout pregnancy gestation. Both supplementations daily orally given at 1 g per kg body weight as a single bolus. Same treatment performed by the following...
Polyunsaturated fatty acids n-3 (PUFA n-3) have shown effects in reducing tumor growth, particular eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) abundantly present fish oil (FO). When these are provided the diet, they alter functions of cells, particularly immune cells. However, α-linolenic (ALA), which is precursor EPA DHA, controversial. Thus, our objective was to test effect this parental acid.Non-tumor-bearing tumor-bearing Wistar rats (70 days) were supplemented with 1 g/kg body...
Physical activity has been used in cancer prevention and treatment. In this study, we investigated some of the mechanisms by which anaerobic exercise reduces tumor growth. To do so, rats were trained for 8 weeks. Training consisted jumping a swimming pool ten 30-s sets, with load that was 50% body weight attached to back, 4 times per week. At sixth week, (EX group) inoculated suspension Walker 256 cells. Tumor weight, apoptotic cells, Bax Bcl-2 protein expression, lipid peroxidation, cell...
The objective of the present work was to study renal function healthy and tumor-bearing rats chronically supplemented with fish oil (FO), a source n-3 polyunsaturated fatty acids. Weanling male were divided in two groups, one control (C) another orally for 70 days FO (1 g/kg body weight). After this time, half animals each group injected right flank suspension Walker 256 tumor cells (W WFO). W had less proteinemia reflecting cachectic proteolysis, reversed fact. Tumor weight gain also...
We investigated the effect of chronic supplementation with shark liver oil (SLO), an antitumor supplement source n-3 fatty acids and 1-O-alkylglycerols, alone combined coconut fat (CF), a saturated acids, on Walker 256 tumor growth cachexia. Male rats were supplemented daily orally SLO and/or CF (1 g per kg body weight) for 7 wk. After wk, 50% animals subcutaneously inoculated 3 × 10(7) cells. 14 days, killed, tumors removed lipid peroxidation measurement, blood was collected glycemia,...
Abstract Here we investigated the effect of lifelong supplementation diet with coconut fat (CO, rich in saturated fatty acids) or fish oil (FO, n‐3 polyunsaturated on tumor growth and lactate production from glucose Walker 256 cells, peritoneal macrophages, spleen, gut‐associated lymphocytes. Female Wistar rats were supplemented CO FO prior to mating then throughout pregnancy gestation male offspring weaning until 90 days age. Then they inoculated subcutaneously cells. Tumor weight at 14...
Campomanesia xanthocarpa Berg. (Myrtaceae), also known as “guabiroba”, is widely distributed in the South and Southern regions of Brazil has been used by local families folk medicine to treat several diseases. This study aimed evaluate bioactive compounds guabiroba fruits leaves, such flavonoids, carotenoids, chlorophyll, total phenolics, tannins, coumarins. The biological effect different parts C. (leaf pulp) was investigated for immunomodulatory activity on RAW 264.7 macrophages,...
A health and weight awareness program was initiated in 1995 by the Tonga National Food Nutrition Committee to combat a high prevalence of obesity its associated non-communicable diseases. The strategy provide fun activity which people wanted join, at same time gain benefits. Three successive loss competitions were organized, 4 6 months length, radio, television, newspaper media major elements. Tongan version 1993 South Pacific Commission for height chart produced, allowing identification...
We investigated the effect of fish oil (FO) supplementation on tumor growth, cyclooxygenase 2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARγ), and RelA gene protein expression in Walker 256 tumor-bearing rats. Male Wistar rats (70 days old) were fed with regular chow (group W) or supplemented 1 g/kg body weight FO daily WFO) until they reached 100 age. Both groups then inoculated a suspension ascitic cells (3×107 cells/mL). After 14 killed, total RNA was isolated from...
Achyrocline satureioides, a medicinal plant widely used in Brazilian traditional medicine for diverse healing applications, has been underexplored its potential anticancer properties. This study aimed to investigate the antitumor of A. satureioides extract on SK-Mel-28 melanoma cells, using an innovative approach devised by authors that involves potentiating solution iron dextran enhance efficacy bioactive and agents. The was characterized phytochemical composition, antioxidant effect,...
By-products generated in the winemaking industry contain compounds with health-promoting properties, which can be reintroduced into food production chain. This study evaluated use of a by-product from industrial processing grapes as an ingredient manufacture Petit Suisse cheese, made A2A2 milk and addition probiotic Bifidobacterium animalis subsp. lactis HN019. Two formulations were three independent batches: control formulation without (F0) containing 10% (F1). The proximate composition...
Achyrocline satureioides (Lam.) DC. is a medicinal plant traditionally used in Brazilian ethnomedicine through infusion and decoction for various therapeutic purposes. The objectives were to determine the antimicrobial activity of A. extract against Pseudomonas aeruginosa describe novel technique using iron dextran solution enhance bioactive compounds agents. was characterized phytochemical composition, antioxidant vitro, activity. exhibited high content phenolic considerable Concerning...