A5072900836- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Catalytic Processes in Materials Science
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Mesoporous Materials and Catalysis
- Muscle Physiology and Disorders
- Lipid metabolism and biosynthesis
- Advanced Photocatalysis Techniques
- Nuts composition and effects
- Transition Metal Oxide Nanomaterials
- Zeolite Catalysis and Synthesis
- Genetic Neurodegenerative Diseases
- Infant Nutrition and Health
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Nanomaterials for catalytic reactions
- Adsorption and biosorption for pollutant removal
- Carbon dioxide utilization in catalysis
- Antioxidant Activity and Oxidative Stress
Universidade Federal de Minas Gerais
2016-2022
McGill University
2022
Centre in Green Chemistry and Catalysis
2022
Universidade de São Paulo
2012-2019
Instituto Butantan
2019
Universidade Estadual de Campinas (UNICAMP)
2016
Institute of Biomedical Science
2014
The aim of this study was to investigate whether treatment with tributyrin (Tb; a butyrate prodrug) results in protection against diet-induced obesity and associated insulin resistance. C57BL/6 male mice fed standard chow or high-fat diet were treated Tb (2 g/kg body wt, 10 wk) evaluated for glucose homeostasis, plasma lipid profile, inflammatory status. protected obesity-associated resistance dyslipidemia without food consumption being affected. attenuated the production TNFα IL-1β by...
Fish oil (FO), rich in omega-3 polyunsaturated fatty acids, has beneficial effects on changes induced by obesity and partially prevents associated comorbidities. The of FO adipocytes from different adipose tissue depots high-fat (HF) diet obese mice have not been uninvestigated. This is the first study to examine metabolism adipokine production s.c. (inguinal; ING) or visceral (retroperitoneal; RP) white a HF diet-induced mice. Unlike most studies performed previously, supplementation was...
Confinement effects offer unique opportinuties to facilitate reactions in a way favor sustainability... an almost magical way.
High-fat diet (HFD) feeding causes insulin resistance (IR) in skeletal muscle of mice, which affects metabolism and function. The involvement muscle-specific microRNAs the evolution IR during 4, 8, 12 weeks HFD-induced obese mice was investigated. After 4 HFD, were obese, hyperglycemic, hyperinsulinemic; however, their muscles responsive to stimuli. Expressions MyomiRs (miR-1, miR-133a, miR-206) measured soleus not different from those found control mice. 8 HFD feeding, glucose uptake lower...
Abstract Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with main macronutrient in diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD sweetened condensed milk (HS), high-fat (HF), HF (HSHF). After 2 months, increased weight, glucose intolerance, adipocyte size cholesterol levels observed. As compared CD, HS ingested same amount calories whereas HSHF less. had plasma AST activity liver type I...
High consumption of polyunsaturated fatty acids, such as sunflower oil has been associated to beneficial effects in plasma lipid profile, but its role on inflammation and insulin resistance is not fully elucidated yet. We evaluated the effect supplementation inflammatory state condition HFD-induced obese mice. C57BL/6 male mice (8 weeks) were divided four groups: (a) control diet (CD), (b) HFD, (c) CD supplemented with n-6 (CD + n-6), (d) HFD (HFD n-6). by oral gavage at 2 g/Kg body weight,...
Zinc is an essential component of the insulin granule and it possibly modulates secretion signaling. Since resistance a hallmark in development type 2 diabetes mellitus, this study aimed at investigating if zinc supplementation able to improve glucose tolerance β-cell function model resistance. Male C57BL/6 mice were distributed four groups according diet: normal fat (NF); supplemented with ZnCl₂ (NFZ); high-fat (HF); and, chow (HFZ). Intraperitoneal (ipGTT) (ipITT) tolerance, glycemia,...
Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration shown improve lipid profile humans. We evaluated effect macadamia supplementation on sensitivity, inflammation, profile, adipocyte size high-fat (HF) induced obesity mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control (CD), (b) HF, (c) CD supplemented by gavage at 2 g/Kg...
<b><i>Background/Aims:</i></b> To investigate the global changes in DNA methylation and of promoter region peroxisome proliferator-activated receptor gamma transcript variant 2 <i>(Pparg2)</i> gene resulting from a high-fat diet (HFD) and/or fish oil supplementation. <b><i>Methods:</i></b> Fish oil, rich omega-3 polyunsaturated fatty acids, or water was orally administered to male mice for 12 weeks. After first 4 weeks, animals were...
Obesity can lead to a chronic systemic inflammatory state that increases the risk of cancer development. Therefore, this study aimed evaluate alterations in tumor non-infiltrated lymphocytes function and melanoma growth animals maintained on high-fat diet and/or moderate physical exercise program murine model melanoma.Female mice were randomly divided into eight groups: 1) normolipidic control (N), 2) + (NM), 3) (H), 4) (HM), 5) (NE), 6) (NEM), 7) (HE), 8) (HEM). After 8 weeks treatment...
The consequences of two-week hindlimb suspension (HS) on skeletal muscle atrophy were investigated in balanced diet-fed Fat-1 transgenic and C57BL/6 wild-type mice. Body composition gastrocnemius fatty acid measured. Skeletal force, cross-sectional area (CSA), signaling pathways associated with protein synthesis (protein kinase B, Akt; ribosomal S6, eukaryotic translation initiation factor 4E-binding 1, 4EBP1; glycogen synthase kinase3-beta, GSK3-beta; extracellular-signal-regulated kinases...
High-fat diet or high-sugar causes obesity and a chronic low-grade inflammation that leads to the development of diabetes cardiovascular diseases. Inflammation surrounding fat thoracic aorta namely periaortic adipose tissue (PAAT) has been associated with increased prevalence vascular diseases in obesity. C57Bl/6 male mice (12 weeks age) fed whole grain-based commercial (WGD), refined carbohydrate (RCD), plus sweetened condensed milk ad libitum (RCD + CM) high-fat (HFD) for eight were...
This study aimed to assess the effect of macadamia oil (MO) on expression genes involved in proteolytic pathways (Murf‐1 and Atrogin‐1) diet‐induced obese C57/BL6J mice. Mice were fed a control or high‐fat diet (HFD) supplemented not with MO (2.5 mg/kg) for eight weeks. mRNA levels MuRF‐1 atrogin‐1/MAFbx evaluated EDL muscle by real‐time PCR. HDF presented decreased weight when compared (0.28 vs 0.39, respectively), suggesting atrophy. supplementation this 0.34; p<0.05). A significant...