A5061429222- Food composition and properties
- Meat and Animal Product Quality
- Dialysis and Renal Disease Management
- Selenium in Biological Systems
- Colorectal Cancer Screening and Detection
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Cancer Research and Treatments
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Healthcare Decision-Making and Restraints
- Microbial Metabolites in Food Biotechnology
- Folate and B Vitamins Research
- Gut microbiota and health
- Inflammatory mediators and NSAID effects
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Digestive system and related health
- Nutritional Studies and Diet
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Lipids, and Metabolism
- Psychosomatic Disorders and Their Treatments
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
Women's and Children's Health Network
2024
Central Adelaide Local Health Network
2024
The University of Adelaide
1998-2023
Royal Adelaide Hospital
2017-2023
Canada Research Chairs
2021
University of Toronto
2021
Flinders University
2009-2018
Health Sciences and Nutrition
1996-2017
Centre for Cancer Biology
2017
Commonwealth Scientific and Industrial Research Organisation
1995-2015
Scope Dietary supplementation with polyphenol‐rich propolis can protect against experimentally induced colitis. We examined whether different polyphenol compositions of Chinese (CP) and Brazilian (BP) influence their ability to dextran sulfate sodium (DSS)‐induced colitis in rats. Methods results HPLC‐DAD/Q‐TOF‐MS analysis confirmed that CP BP were dissimilar. Rats given or by gavage (300 mg kg −1 body weight) throughout the study, starting 1 week prior DSS treatment for followed 3 d without...
This study evaluated the effect of a probiotic bacteria 'Bifidobacterium lactis', carbohydrate 'resistant starch' (RS) and their combination (synbiotic), on ability to protect against colorectal cancer (CRC). Bifidobacterium lactis has been shown previously utilize RS as substrate up-regulate acute apoptotic response carcinogen in colon [Le Leu et al. (2005) J. Nutr., 135, 996-1001]. Sprague-Dawley rats were divided into six equal groups fed semi-purified diets for 30 weeks. Colonic...
This study evaluated whether dietary resistant starch (RS) and green tea extract (GTE), which have anti-inflammatory anticancer properties, protect against colitis-associated colorectal cancer (CAC) using a rat model, also investigated potential mechanisms of action these agents including their effects on the gut microbiota. Rats were fed control diet or diets containing 10% RS, 0.5% GTE combination two (RS + GTE). CAC was initiated with 2 weekly azoxymethane (AOM) injections (10mg/kg)...
Epidemiological studies have identified increased colorectal cancer (CRC) risk with high red meat (HRM) intakes, whereas dietary fibre intake appears to be protective. In the present study, we examined whether a HRM diet rectal O(6)-methyl-2-deoxyguanosine (O(6)MeG) adduct levels in healthy human subjects, and butyrylated high-amylose maize starch (HAMSB) was A group of twenty-three individuals consumed 300 g/d cooked without (HRM diet) or 40 HAMSB (HRM+HAMSB over 4-week periods separated by...
Diet-derived butyrate, a histone deacetylase inhibitor (HDI), decreases proliferation and increases apoptosis in colorectal cancer (CRC) cells via epigenetic changes gene expression. Other HDIs such as suberoylanilide hydroxamic acid (SAHA) trichostatin A (TSA) have similar effects. This study examined the role of microRNAs (miRNAs) mediating chemo-protective effects HDIs, explored functions oncogenic miR-17-92 cluster. The dysregulated miRNA expression observed HT29 HCT116 CRC could be...
Abstract High red meat (HRM) intake is associated with increased colorectal cancer risk, while resistant starch probably protective. Resistant fermentation produces butyrate, which can alter microRNA (miRNA) levels in cells vitro; effects of and on miRNA expression vivo were unknown. This study examined whether a HRM diet altered rectal mucosa tissue healthy volunteers, if supplementation butyrylated (HRM+HAMSB) modified this response. In randomized cross-over design, 23 volunteers undertook...
Protein as well starch is fermented in the colon, but interaction between protein and fermentation impact on colonic oncogenesis unknown. High-protein diets increase delivery of to colon might promote through generation toxic products. We investigated resistant (RS) with digestion-resistant potato (PP) events their relationship intestinal tumourigenesis. Male Sprague-Dawley rats were fed an AIN-76A-based diet for 4 weeks neoplasms induced by azoxymethane. Experimental included following: no...
We investigated in rats the effects of feeding different forms high amylose maize starches (HAMS) rich resistant starch (RS) to understand what implications RS heterogeneity might be for colonic biology, including innate cellular responses DNA-damage.A range were compared: digestible cornstarch (Control), HYLON® VII, Hi-maize® 1043, 240, 260 and NOVELOSE® 330. Included comparison was Cellulose. End-points after 4 weeks included: pH, short chain fatty acids (SCFA) levels, epithelial cell...
Se and green tea have been shown in epidemiological, observational preclinical studies to be inversely related the risk of developing colorectal cancer (CRC). However, there are limited evaluate their regulatory effects on genes/proteins that relate CRC oncogenesis human subjects, such as selenoproteins, WNT signalling pathway, inflammation methylation. This study examined supplementation using Brazil nuts extract (GTE) capsules, alone combination, targeted biomarkers. In total, thirty-two...
Patient activation refers to the knowledge, confidence and skills required for management of chronic disease is antecedent self-management. Greater self-management in kidney (CKD) results improved patient experience outcomes. To examine levels people with CKD stage 5 pre-dialysis determine associations sociodemographic characteristics, treatment adherence healthcare utilisation. People not receiving dialysis from one Australian care service. was measured using 13-item Activation Measure...
Abstract Population studies have shown that high red meat intake may increase colorectal cancer risk. Our aim was to examine the effect of different amounts and sources dietary protein on induction promutagenic adduct O6-methyl-2-deoxyguanosine (O6MeG) in colonocytes, relate these markers large bowel fermentation ascertain whether increasing colonic carbohydrate modified effects. Mice (n = 72) were fed 15% or 30% as casein with 10% amylose maize starch source resistant starch. Genetic damage...
Propolis is an important hive product and considered beneficial to health. However, evidence of its potential for improving gut health still lacking. Here we use rats examine whether dietary supplementation with propolis could be used as a therapy ulcerative colitis. Rats were fed Western style diet alone (controls) or supplemented different amounts Chinese (0.1%, 0.2%, 0.3%) effects on acute colitis induced by 3% dextran sulphate sodium (DSS) in drinking water. at 0.3%, but not lower...
Alterations in folate status may play an important role carcinogenesis. The aim of this study was to examine the effect a diminished on azoxymethane (AOM)-induced intestinal tumours Sprague-Dawley rats. A total 125 weanling male rats were divided into five equal groups and fed semi-purified diets containing either 8 mg/kg or no folate. After 4 weeks experimental diets, all animals received three weekly subcutaneous injections AOM at dose rate 15 bodyweight. necropsied after 26 weeks. Rats...
Fermentation of polysaccharides in the colon seems likely to regulate tumorigenesis but mechanisms are unclear. A possible mechanism may be through facilitation acute apoptotic response genotoxin-induced DNA damage. This study evaluated effects selected dietary polysaccharides, resistant starch (supplied as Hi-maize) and nonstarch wheat bran cellulose) on certain biological events relevant protection against cancer (fecal bulk, pH, butyrate apoptosis). Male Sprague–Dawley rats were fed...
The effect of different doses a type-2 resistant starch (RS) in the form high amylose cornstarch (HAS) on intralumenal environment and acute-apoptotic response to genotoxic carcinogen (AARGC) colon was assessed determine if changes lumenal conditions were associated with an enhanced apoptotic DNA damage. control diet modified AIN-76 containing fully digestible but no dietary fibre. HAS added at expense give 10% HAS, 20% 30% HAS. Rats fed experimental diets for period 4 weeks, after which...