A5082321192- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Health and Lifestyle Studies
- Healthcare Regulation
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Body Composition Measurement Techniques
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Children's Physical and Motor Development
- Diet and metabolism studies
- Physical Activity and Health
- Muscle Physiology and Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Physical Education and Gymnastics
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
- NF-κB Signaling Pathways
- Youth, Drugs, and Violence
Universidade de São Paulo
2016-2025
Universidade Estadual Paulista (Unesp)
2011-2020
Instituto Butantan
2020
Hospital Regional de Presidente Prudente
2013-2018
San Antonio College
2018
University of Coimbra
2018
Universidade Paulista
2015-2017
American Physical Therapy Association
2012
Palmitoleic acid (PM, 16:1n-7) has anti-inflammatory properties that could be linked to higher expression of PPARα, an inhibitor NFκB. Macrophages play a major role in the pathogenesis chronic inflammation, however, effects PM on macrophages are underexplored. Thus, we aimed investigate activated as well PPARα. Primary were isolated from C57BL/6 wild type (WT) and PPARα knockout (KO) mice, cultured under standard conditions exposed lipopolysaccharides LPS (2.5 μg/ml) 600 μmol/L conjugated...
Previous studies have shown an association between adiposity, especially intra-abdominal adipose tissue, and hemodynamic/metabolic comorbidities in adults, however it is not clear pediatric population. The aim of the study was to analyze relationship non-alcoholic fatty liver disease (NAFLD) components metabolic syndrome (MS) with values (IAAT) subcutaneous (SCAT) tissue obese children adolescents.Cross-sectional study.182 sedentary adolescents (aged 6 16 y), identified by body mass index...
Palmitoleic acid (POA, 16:1n-7) is a lipokine that has potential nutraceutical use to treat non-alcoholic fatty liver disease. We tested the effects of POA supplementation (daily oral gavage, 300 mg/Kg, 15 days) on murine inflammation induced by high fat diet (HFD, 59% fat, 12 weeks). In HFD-fed mice, reduced serum insulin and improved tolerance compared with oleic (OA, mg/Kg). The livers POA-treated mice exhibited less steatosis than those OA-treated lower inflammatory cytokine levels...
Nonalcoholic fatty liver disease (NAFLD) is a disorder associated with excessive fat accumulation, mainly in the intra-abdominal region. A simple technique to estimate abdominal this region could be useful assess presence of NAFLD, obese subjects who are more vulnerable disease. The aim cross-sectional study was verify reliability waist circumference and body composition variables identify occurrence NAFLD children adolescents. Sample composed 145 subjects, aged 11 17 years. Assessments...
Abstract Background Recent studies have identified that a higher resting heart rate (RHR) is associated with elevated blood pressure, independent of body fatness, age and ethnicity. However, it still unclear whether RHR can also be applied as screening for other risk factors, such hyperglycemia dyslipidemia. Thus, the purpose presented study was to analyze association between RHR, lipid profile fasting glucose in obese children adolescents. Methods The sample composed 180 adolescents, aged...
Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration shown improve lipid profile humans. We evaluated effect macadamia supplementation on sensitivity, inflammation, profile, adipocyte size high-fat (HF) induced obesity mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control (CD), (b) HF, (c) CD supplemented by gavage at 2 g/Kg...
Nonalcoholic fatty liver disease (NAFLD) is one of the main diseases today, and may progress to steatohepatitis, cirrhosis, hepatocellular carcinoma. Some studies have shown beneficial effects aerobic exercise on reversing NAFLD. To verify whether chronic improves insulin resistance, inflammation, steatohepatitis caused by a high fat diet (HF) PPARα involved in these actions. C57BL6 wild type (WT) PPAR-α knockout (KO) mice were fed with standard (SD) or HF during 12 weeks; trained treadmill...
The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed evaluate effects endurance exercise on time-dependent caused by doxorubicin. For this, C57 BL/6 mice were subcutaneously inoculated with Lewis lung carcinoma cells (LLC group). One week after tumor establishment, group these animals initiated doxorubicin alone + DOX group) or combined EXER was euthanized cycle, whereas remaining one...
Macrophages are key regulators of adipose tissue plasticity. Obesity impairs brown (BAT) function in humans, yet macrophage-mediated mechanisms remain elusive. Here, we introduce MACanalyzeR, a single-cell RNA sequencing (scRNAseq) tool designed for comprehensive monocyte/macrophage metabolic profiling. Applying MACanalyzeR to BAT from obese male murine models (db/db and HFD-fed mice), identify lipid-associated macrophages (LAMs) with foamy characteristics. Unlike db/db LAMs, those HFD...
Doxorubicin (DX) is a chemotherapeutic drug that used in clinical practice promotes deleterious side effects non-tumor tissues such as adipose tissue. We showed DX leads to extensive damage tissue via disruption 5'-adenosine monophosphate-activated protein kinase (AMPK) and PPAR-gamma signaling. Thus, we investigated whether co-treatment with the biguanide metformin (MET) could prevent of through activation AMPK The goal present study was verify adjuvant MET treatment subcutaneous (SAT)...
Metabolic Syndrome (MS) is defined as a group of risk factors related to insulin resistance and its highest prevalence found in obese individuals. The first observations concerning MS occurred the 1920s, contributing surge new associations between hyperglycemia obesity. As 1979, there was greater understanding one components: resistance. varies according diagnostic criterion used, mainly for children adolescents among which has increased considerably. principle criteria used diagnosing...
OBJECTIVE To analyze the effects of a 20-week concurrent training on variables body composition, lipid profile, and fatty liver diagnosis in obese adolescents. METHODS An open clinical trial was carried out with 34 adolescents aged between 12 15 years. Total fat, trunk fat mass, total cholesterol its fractions (HDL, LDL VLDL), triglycerides were analyzed; an upper abdominal ultrasound performed order to diagnose liver. The participants underwent (association weight aerobic training) three...
Exercise is a powerful tool for prevention and treatment of many conditions related to the cardiovascular system also chronic low-grade inflammation. Peroxisome proliferator-activated receptors γ (PPARγ) exerts an import role on regulation metabolic profile subsequent inflammatory response, especially in macrophages.To investigate effects 8-week moderate-exercise training parameters mice with PPARγ deficiency myeloid cells.Twelve-week old bearing deletion exclusively cells (PPARγlox/lox Lys...
Peroxisome proliferator‐activated receptors (PPARs) play a major role in metabolism and inflammatory control. Exercise can modulate PPAR expression skeletal muscle, adipose tissue, macrophages. Little is known about the effects of PPAR‐α metabolic profile cytokine secretion after acute exercise In this context, aim study was to understand influence on exercise‐mediated immune parameters peritoneal Mice C57BL/6 (WT) knockout (KO) were examined non‐exercising control ( n = 4) or 24 hours...
Objective The purpose of the present study was to analyze effects a 20-week concurrent training (20 WCT) intervention program on gender-specific body composition and metabolic variables in obese adolescents. Subjects methods Sample composed twenty-five adolescents, aged between 12 15 (13.4 ± 0.96) years. Fat-free mass (FFM), percentage trunk fat (TFM%) (%FM) were evaluated through dual-energy X-ray absorptiometry (DXA). Measurement intra-abdominal adiposity (IAAT) performed using ultrasound....
Circadian rhythm is essential for cellular regulation of physiological, metabolic, and immune functions. Perturbations circadian rhythms have been correlated with increased susceptibility to cancer poor prognosis in the treatment. Our aim investigate role doxorubicin (DOX) treatment on clock genes expression inflammation intraperitoneal macrophages antitumoral response.Macrophages were extracted from cavity mice without or Lewis lung carcinoma (LLC) treated DOX totaling four groups (CTL,...
Colorectal cancer affects the large intestine, leading to loss of white adipose tissue (WAT) and alterations in adipokine secretion. Lower incidence colorectal is associated with increased fibre intake. Fructooligosaccharides (FOS) are fibres that increase production butyrate by intestinal microbiota. Tributyrin, a prodrug butyric acid, exerts beneficial anti-inflammatory effects on cancer. Our aim was characterise diets rich FOS tributyrin within context colon carcinogenesis model, possible...
Background Even though doxorubicin (DOX) chemotherapy promotes intense muscle wasting, this drug is still widely used in clinical practice due to its remarkable efficiency managing cancer. On the other hand, loss during oncological treatment considered a bad prognosis for disease’s evolution and patient’s quality of life. In sense, strategies that can counteract wasting induced by DOX are essential. study, we evaluated effectiveness formoterol (FOR), β2-adrenoceptor agonist, caused DOX....
ABSTRACT Macrophages in brown adipose tissue (BAT) play a complex role regulating its activity. However, the of macrophages BAT activation/deactivation has not yet been comprehensively characterized. To elucidate this, we developed MACanalyzeR, scRNAseq-based tool specifically designed to explore macrophage features at molecular and metabolic level. MACanalyzeR was applied scRNA-seq datasets obtained from with thermogenic loss (db/db mice) activation (High Fat Diet, HFD). Our computational...