A5100401157- Microencapsulation and Drying Processes
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Fluid Dynamics and Heat Transfer
- Medicinal plant effects and applications
- Synthesis and properties of polymers
- Phytochemical and Pharmacological Studies
- Food Industry and Aquatic Biology
- HIV/AIDS drug development and treatment
University of Alberta
2021-2023
Shaanxi University of Chinese Medicine
2020
Carrier-free spray-dried dispersions for pulmonary delivery, which the demand is growing, frequently require incorporation of dispersibility-enhancing excipients into formulations to improve efficacy dosage form. One most promising such excipients, L-leucine, expected be approved inhalation soon and has been studied exhaustively. However, during stability, small fibers protruding from particles leucine-containing powders have occasionally observed. To clarify origin these assess their...
Abstract The aim of this work was to encapsulate sea buckthorn ( Hippophae rhamnoides L.) pulp oil (SBPO) by spray drying. Gum Arabic (GA) and maltodextrins (MD) were used as wall materials. effects several factors, including GA MD ratio, total solids content emulsion, core inlet air temperature, on the microencapsulation efficiency (ME) investigated. optimization operation conditions realized response surface methodology (RSM). optimal follows: ratio 2.38, 39%, 5.33, temperature 154°C....
The purpose of this study was twofold: to investigate leucine crystallization kinetics in co-solvent spray drying for a deeper understanding the morphology and formation process spray-dried crystalline particles, also develop multi-orifice plates using gallium focused ion beam milling order increase production rate monodisperse drying. A technique vibrating orifice atomizer equipped with beam-manufactured dual-orifice plate used produce model particles study. achieved an average 23.8 ± 2.0...
Amorphous nifedipine powders were prepared by spray-drying with 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) or polyvinylpyrrolidone K-30 (PVP). Upon storage of the products at a high temperature and humidity, crystallized in matrices, yielding both bigger crystals (>50 μm) PVP matrix smaller (about 5 HP-β-CyD matrix. The release from tablets containing complex was accelerated upon storage, whereas that solid dispersion decelerated. deceleration rate attributable to growth larger size early...