A5088239035- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Apelin-related biomedical research
Cold Spring Harbor Laboratory
2020-2022
The central amygdala (CeA) is critically involved in a range of adaptive behaviors, including defensive behaviors. Neurons the CeA send long-range projections to number extra-amygdala targets, but functions these remain elusive. Here, we report that previously neglected CeA-to-globus pallidus external segment (GPe) circuit plays an essential role classical fear conditioning. By anatomic tracing, situ hybridization and channelrhodopsin (ChR2)-assisted mapping both male female mice, found...
Abstract The rules governing behavior often vary with behavioral contexts. As a consequence, an action rewarded in one context may be discouraged another. Animals and humans are capable of switching between strategies under different contexts acting adaptively according to the variable rules, flexibility that is thought mediated by prefrontal cortex (PFC) 1–4 . However, how PFC orchestrates context-dependent switch remains unclear. Here we show pathway-specific projection neurons medial...
Abstract The central amygdala (CeA) is critically involved in a range of adaptive behaviors. In particular, the somatostatin-expressing (Sst + ) neurons CeA are essential for classic fear conditioning. These send long-range projections to several extra-amygdala targets, but functions these remain elusive. Here, we found mice that subset Sst globus pallidus external segment (GPe), and constitute essentially entire GPe-projecting population. Notably, chronic inhibition completely blocks...
SUMMARY Overeating and a sedentary life style are major causes of obesity related metabolic disorders. Identification the neurobiological processes that regulate energy balance will facilitate development interventions for these Here we show Neurotensin-expressing neurons in mouse IPAC (IPAC Nts ), nucleus central extended amygdala, bidirectionally coordinate hedonic feeding physical activity, thereby regulating balance, bodyweight. preferentially activated by consumption highly palatable...