A5042735576- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Biosensors and Analytical Detection
- COVID-19 diagnosis using AI
- vaccines and immunoinformatics approaches
- Genomics and Phylogenetic Studies
MRC Unit the Gambia
2020-2024
UK Research and Innovation
2023
London School of Hygiene & Tropical Medicine
2023
National Public Health Laboratory
2023
University of Sheffield
2023
Abstract Background This detailed genomic study characterised multi-drug resistant-Gram negative bacilli (MDR-GNB) carriage in neonates < 2 kg and paired mothers at a low-resource African hospital. Methods cross-sectional cohort was conducted the neonatal referral unit The Gambia with weekly skin peri-anal sampling maternal recto-vaginal swabs. Prospective bacteriological culture used MacConkey agar species identification by API20E API20NE. All GNB isolates underwent whole genome...
The SARS-CoV-2 disease, first detected in Wuhan, China, December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems the economy globally. While travel history of index cases may suggest origin infection, phylogenetic analysis isolated strains from these contacts will increase understanding link between local transmission other populations. objective this was to provide genomic data six Gambia determine source infection. This ultimately baseline...
Abstract Background COVID-19, caused by SARS-CoV-2, is one of the deadliest pandemics over last 100 years. Sequencing playing an important role in monitoring evolution virus, including detection new viral variants. This study describes genomic epidemiology SARS-CoV-2 infections The Gambia. Methods Nasopharyngeal and/or oropharyngeal swabs collected from suspected cases and travellers were tested for using standard RT-PCR methods. positive samples sequenced following library preparation...
Abstract The rapid emergence and global dissemination of SARS-CoV-2 highlighted a need for robust, adaptable surveillance systems. However, financial infrastructure requirements whole genome sequencing (WGS) mean most data have come from higher-resource geographies, despite unprecedented investment in low-middle income countries (LMICs) throughout the pandemic. Consequently, molecular epidemiology some LMICs is limited, there more cost-accessible technologies to help close gaps variants. To...
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a positive-sense single stranded RNA virus with high human transmissibility. This study generated Whole Genome data to determine the origin and pattern of transmission SARS-CoV-2 from first six cases tested in The Gambia. Total was extracted inactivated nasopharyngeal-oropharyngeal swabs converted cDNA following ARTIC COVID-19 sequencing protocol. Libraries were constructed NEBNext ultra II DNA library prep kit for...
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a positive-sense single stranded RNA virus with high human transmissibility. This study generated Whole Genome data to determine the origin and pattern of transmission SARS-CoV-2 from first six cases tested in The Gambia. Total was extracted inactivated nasopharyngeal-oropharyngeal swabs converted cDNA following ARTIC COVID-19 sequencing protocol. Libraries were constructed NEBNext ultra II DNA library prep kit for...
Abstract Aim This detailed genomic study aimed to characterise multi-drug resistant-gram negative bacilli (MDR-GNB) intestinal and skin carriage in small vulnerable newborns their paired mothers at a low-resource African hospital. Methods cross-sectional cohort was conducted the only neonatal referral unit The Gambia with analysis MRC Unit LSHTM. Neonates <2kg underwent peri-anal swab sampling weekly maternal rectovaginal swabs. Prospective bacteriological culture used MacConkey agar...