A5051198228- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Organoboron and organosilicon chemistry
- Synthesis and Reactions of Organic Compounds
- Carbon dioxide utilization in catalysis
- Catalytic Processes in Materials Science
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Genetic Associations and Epidemiology
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Neuroimaging Techniques and Applications
- Marine Sponges and Natural Products
- Alkaloids: synthesis and pharmacology
- Catalysis and Oxidation Reactions
Cardiff University
2018-2022
University of Bath
2002-2021
Clave (Brazil)
2020
Imperial College London
1992
East Cheshire NHS Trust
1992
A series of two-coordinate copper tert-butoxide complexes bearing five-, six-, and seven-membered ring N-heterocyclic carbenes, prepared by protonolysis (NHC)CuMes with tBuOH, have been used as catalytic precursors in the semihydrogenation alkynes silanes/tBuOH hydroboration HBPin. Both processes proceed high regioselectivity show enhancements six- carbenes.
There has been growing interest in performing organocatalysis within a supramolecular system as means of controlling reaction reactivity and stereoselectivity. Here, protein is used host for iminium catalysis. A pyrrolidine moiety covalently linked to biotin introduced the streptavidin organocatalytic activity. Whereas traditional systems stereoselectivity largely controlled by substituents added organocatalyst, enantiomeric enrichment reported completely host. Also, yield model increases...
A range of N-heterocyclic carbene-supported copper diphenylphosphides (NHC = IPr, 6-Dipp, SIMes and 6-Mes) were synthesised. These include the first reports ring-expanded NHC-copper(i) phosphides. The compounds characterised by NMR spectroscopy X-ray crystallography. Reaction (6-Dipp)CuPPh2 with isocyanates, isothiocyanates carbon disulfide results in insertion heterocumulene into Cu-P bond. NHC-copper phosphides found to be most selective catalysts yet reported for hydrophosphination...
Reaction of bis(pinacolato)diboron with (6-Dipp)CuOtBu generates a ring-expanded N-heterocyclic carbene supported copper(I) boryl, (6-Dipp)CuBpin. This compound showed remarkable stability and was characterised by NMR spectroscopy X-ray crystallography. (6-Dipp)CuBpin readily dechalcogenated range heterocumulenes such as CO2, isocyanates isothiocyanates to yield (6-Dipp)CuXBpin (X = O, S). In the case CO2 catalytic reduction CO is viable in presence excess bis(pinacolato)diboron. contrast,...
Abstract There has been growing interest in performing organocatalysis within a supramolecular system as means of controlling reaction reactivity and stereoselectivity. Here, protein is used host for iminium catalysis. A pyrrolidine moiety covalently linked to biotin introduced the streptavidin organocatalytic activity. Whereas traditional systems stereoselectivity largely controlled by substituents added organocatalyst, enantiomeric enrichment reported completely host. Also, yield model...
Five examples of two-coordinate copper(I) fluoride complexes stabilized by five-, six-, and seven-membered-ring N-heterocyclic carbenes or a cyclic (alkyl)(amino)carbene have been prepared, structurally characterized, employed in the catalytic allylation octanal. The very bulky trityl-based carbene ITr affords most active system. Mechanistic studies led to isolation (ITr)Cu(CH2CHCH2) [{(6-Mes)Cu}2(μ-OEt)][SiF5], which along with fluorosilane (EtO)3SiF are relevance cycle.
The facile syntheses of ring-expanded N-heterocyclic carbene (RE-NHC) copper(I) halide complexes are reported. method makes use a weak inorganic base in green solvent. reaction times can be greatly reduced by this weak-base route under microwave irradiation. easy access to these permits an evaluation the catalytic activity and profiling [Cu(RE-NHC)X] Huisgen 1,3-cycloaddition reaction.
The synthesis of some 2-acyl-thiazoles and -imidazoles is described. In the subsequent aldol condensation these ketones, imidazole congeners were much better behaved. N-Methylation aldols was only partially successful suffered from competing O-methylation hydroxy group. A diastereoisomeric imidazolium salt one did not close to a β-lactone on treatment with base but undergo clean de-acylation in presence methanol give corresponding β-hydroxy ester stereospecifically.
Reaction of the anion 2-(1-tri-isopropylsiloxyallyl)-N-methoxymethylimidazole with ketones and aldehydes proceeds regioselectivity to give enol silyl ethers 2-acylimidazoles which suffer cleavage γ-lactones after desilylation, N-methylation, base treatment.
Abstract Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts schizophrenia (SCZ). However, we know little about the influence common genetic risk factors for SCZ efficiency routing structural brain networks (SBNs). Here, use novel recall-by-genotype approach, where sample young adults from population-based cohort (ALSPAC:N genotyped = 8,365) their burden alleles as defined by polygenic score (PRS). We compared 181...
An experimental study has been carried out to assess the capability of injecting vaporized fuel into exhaust gas a diesel engine achieve elevated outlet temperatures from an oxidation catalyst for thermal regeneration particulate filters. Termed catalytic combustion and passive in nature, controlled experiments have proved concept with limitation on temperature being dictated by material limits system availability oxygen.