A5029851981- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Physics of Superconductivity and Magnetism
- Advanced Condensed Matter Physics
- SARS-CoV-2 and COVID-19 Research
- Quinazolinone synthesis and applications
- COVID-19 Clinical Research Studies
- Culinary Culture and Tourism
- Cancer-related molecular mechanisms research
- Antibiotics Pharmacokinetics and Efficacy
- Dermatological and COVID-19 studies
- Ubiquitin and proteasome pathways
- COVID-19 Impact on Reproduction
- Autoimmune and Inflammatory Disorders Research
- Magnetic and transport properties of perovskites and related materials
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Central Venous Catheters and Hemodialysis
- Personal Information Management and User Behavior
- Cancer Treatment and Pharmacology
- Intravenous Infusion Technology and Safety
- Blood disorders and treatments
- Cancer Immunotherapy and Biomarkers
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
Peking Union Medical College Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
The long peripheral intravenous catheter (long PIVC), a type of PIVC, has an indwelling time 5–14 days and is one the options for antibacterial therapy. However, there no consensus regarding impact insertion site selection on complications associated with PIVCs. This randomized controlled trial included 90 participants randomly assigned to either control or experimental group, 45 patients in each group. In PIVCs were placed forearm, while they inserted upper arm. primary outcome was...
Abstract Background Myc rearrangement (Myc‐R) is a controversial factor linked to adverse outcomes in newly diagnosed multiple myeloma (NDMM). Aims This study aimed evaluate the impact of Myc‐R on prognosis NDMM patients and its role risk stratification compared with traditional high‐risk cytogenetic abnormalities (HRCAs). Materials & Methods A total 417 enrolled from May 2009 September 2022 were included. Fluorescence situ hybridization (FISH) was used detect other (Myc‐OA). Median...
The definition of primary plasma cell leukemia (pPCL) has been revised from ≥20% to ≥5% circulating cells (CPC). However, the precise prognosis associated with CPC remains controversial. This study aimed investigate prognostic biomarkers for myeloma patients based on presence.
Abstract Objective To study the cytogenetic characteristics of extramedullary disease (EMD) in patients with multiple myeloma (MM) and their impact on prognosis. Methods Patients newly diagnosed MM (NDMM) at Peking Union Medical College Hospital (Beijing, China) between June 2007 December 2019 were recruited for this study. Demographic information, clinical data, fluorescence situ hybridization (FISH) results marrow tissue samples, survival outcome data collected. Results A total 439 NDMM...
Graphical Abstract A second bone marrow aspiration and biopsy showed pure red cell aplasia in this case.
Materials potentially hosting Kitaev spin-liquid states are considered crucial for realizing topological quantum computing. However, the intricate nature of spin interactions within these materials complicates precise measurement low-energy excitations indicative fractionalized excitations. Using Na$_{2}$Co$_2$TeO$_{6}$ as an example, we study using time-resolved resonant elastic x-ray scattering (tr-REXS). Our observations unveil remarkably slow dynamics at magnetic peak, whose recovery...
At the end of 2022, a huge tide SARS-CoV-2 infection mainly Omicron BA.4/5 developed in China. Multiple myeloma (MM) patients suffered cancer deterioration and mortality from COVID-19, yet profound analyses variants-induced immunity function are scarce. We presented longitudinal study 218 MM 73 healthy controls (HCs), reporting prognostic factors dynamic humoral cellular immune responses. Neutralizing antibody interferon γ ELISpot assay was tested at three time points: 2-4, 8-10, 14-16 weeks...
Background Broad T cell phenotypic alterations and potential dysfunctions were prominent in COVID-19. There are few inconclusive data about the role of immune checkpoints for exhaustion/activation during SARS-CoV-2 infection multiple myeloma (MM) patients. Methods We tested subsets 177 MM patients with COVID-19, as well 32 healthy infected controls 42 uninfected The percentage CD4+ CD8+ subpopulation (PD-1, TIGIT, TIM-3, LAG-3, CTLA-4, OX40, 4-1BB) evaluated by flow cytometry. Results have...
Abstract The novel coronavirus (SARS-CoV-2) infection has become a heavy burden on global health. Although the disease 2019 (COVID-19) may adversely affect multiple organs and systems of infected patients, to best our knowledge, there is little investigation SARS-CoV-2's impact bone marrow. Our clinical cytological findings in this case severe COVID-19 provide insights into pathogenesis SARS-CoV-2 hematopoietic system. We recommend that physicians consider infection's effect marrow patients...