A5078045205- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Breast Lesions and Carcinomas
- Digital Radiography and Breast Imaging
- Nanoplatforms for cancer theranostics
- Breast Cancer Treatment Studies
- Thermography and Photoacoustic Techniques
- Ultrasound in Clinical Applications
- COVID-19 and healthcare impacts
- Ultrasound and Hyperthermia Applications
- Infection Control and Ventilation
- Climate Change and Health Impacts
- Medical Imaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Nutrition and Health in Aging
- AI in cancer detection
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Vascular Anomalies and Treatments
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
National University Hospital
2016-2025
National University of Singapore
2019
Photoacoustic imaging, an emerging modality that seamlessly combines advantages of optical absorption contrast and ultrasound resolution, holds great promise for noninvasive imaging biological tissues. Its applications span across diverse fields, such as dermatology, oncology, cardiology, neurology. However, achieving accurate image reconstruction physiological parameters quantification from raw photoacoustic signals presents a significant challenge. This challenge primarily arises the...
Clinical Practice Points•Multispectral optoacoustic tomography (MSOT) is an innovative state-of-the-art imaging modality that has gained popularity for in vivo breast recent years.•Combining high-resolution images with endogenous differentiation of biochemical contents, MSOT could be accurate ex assessment tumor margins during breast-conserving surgery to reduce margin positivity rates.•Accurate intraoperative lead more precise surgery, allowing a smaller volume tissue removed without...
In this pilot study, we investigated the utility of handheld ultrasound-guided photoacoustic (US-PA) imaging probe for analyzing ex-vivo breast specimens obtained from female patients who underwent breast-conserving surgery (BCS). We aimed to assess potential US-PA in detecting biochemical markers such as collagen, lipids, and hemoglobin, compare these findings with routine modalities (mammography, ultrasound) histopathology results, particularly across various densities. Twelve were a mean...
Abstract Objective To develop a risk predictor model in evaluation of tomosynthesis-detected architectural distortion (AD) based on characteristics contrast-enhanced digital mammography (CEDM). Methods Ninety-four AD lesions CEDM combination with tomosynthesis were retrospectively reviewed from 92 consecutive women (mean age, 52.4 years ± 7.9) abnormal diagnostic or screening mammography. results correlated histology ADs using cross-tabulation for statistical analysis. Predictors malignancy...
Abstract Objective To evaluate the impact of pre-operative contrast-enhanced mammography (CEM) in breast cancer patients with dense breasts. Methods We conducted a retrospective review 232 histologically proven cancers 200 women (mean age: 53.4 years ± 10.2) who underwent pre-surgical CEM imaging across two Asian institutions (Singapore and Taiwan). Majority (95.5%) had tissue (BI-RADS category C or D). Surgical decision was recorded simulated blinded multi-disciplinary team setting on...
In this pilot study, we tested an ultrasound-guided optoacoustic tomography (US-OT) two-dimensional (2D) array scanner to understand the patterns of excised breastconserving surgery (BCS) specimens. We imaged 14 BCS specimens containing malignant tumors at eight wavelengths spanning 700-1100 nm. Spectral unmixing across multiple allowed for visualizing major intrinsic chromophores in breast tissue including hemoglobin and lipid up a depth 7 mm. identified less/no signals within tumor intense...
To assess the efficacy of contrast-enhanced mammography (CEM) in differentiating benign from malignant breast lesions Asian patients with bloody nipple discharge (BND).
Unexplained weight loss is a non-specific complaint with myriad potential etiologies. Increasingly, whole body CT studies are being performed in patients unexplained to exclude organic etiologies such as malignancy. Our study aims assess the diagnostic accuracy and yield of these patients.Patients who had scan for investigation their primary from 2009-2012 were retrospectively reviewed. scans classified into 4 categories: (1) Definite/highly suspicious underlying cause (2) Indeterminate (3)...
PURPOSE: To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment tumor margins postlumpectomy. METHODS: A custom-built two-dimensional (2D) US-OT–handheld was used to scan 15 lumpectomy breast specimens. Optoacoustic signals acquired at multiple wavelengths between 700 and 1100 nm were reconstructed using model linear algorithm, followed by spectral unmixing lipid deoxyhemoglobin (Hb)....
A 50-year-old woman with no past medical history presented a left anterior chest wall mass that was clinically soft, mobile, and non-tender. targeted ultrasound (US) showed findings suggestive of lipoma. However, focal "mass-like" nodules seen within the inferior portion suggested malignant transformation lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy excision histological confirmation. T1-weighted image demonstrated large lipoma has central...
A survey of hospitals on three continents was performed to assess their infection control preparedness and measures, rate in hospital health care workers during the COVID-19 pandemic. All surveyed used similar PPE but differences preparedness, shortages, rates were reported.
A low test threshold for pulmonary embolism(PE) and over reliance on imaging, especially CT angiograms(CTPA) is a common behaviour pattern among physicians. Interventions to improve this CTPA testing have been mostly ineffective. The innovative Dutch YEARS study reported fewer examinations in PE diagnosis(van der Hulle et al. Lancet 2017;390:289). However, the algorithm not evaluated routine clinical practice. Thus, we examined effects of implementing pragmatic, modified version diagnosis....
This case report demonstrates the potential of contrast-enhanced ultrasound (CEUS) in diagnosing active arterial wall inflammation a symptomatic patient with Takayasu arteritis (TA). To our knowledge, this is first which pictorial correlation neovascularity on CEUS mural edema magnetic resonance imaging and metabolic activity positron emission tomography - computed same patient. As TA chronic disease requires long-term follow-up, could be modality choice as it radiation-free, non-nephrotoxic...