A5075348694- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
Karolinska Institutet
2019-2023
Karolinska University Hospital
2019-2023
Harvard University
2016
T cells differentiate into functionally distinct states upon antigen encounter. These are delineated by different cell surface markers for murine and human cells, which hamper cross-species translation of properties. We aimed to identify that reflect the graded nature CD8+ differentiation delineate comparable in mice humans. CITEseq analyses revealed expression CX3CR1, encoding chemokine receptor correlated with gradient. CX3CR1 distinguished CD4+ states, as defined migratory functional...
Expression levels of the chemokine receptor CX3CR1 serve as high-resolution marker delineating functionally distinct antigen-experienced T-cell states. The factors that influence expression in T cells are, however, incompletely understood. Here, we show vitro priming naïve CD8
Abstract CD8 T cells are crucial for the protection against tumors and intracellular pathogens via their ability to generate long-term memory. Memory (TMem) however not a homogenous population. Traditionally, blood-borne TMem have been sub-divided into central memory (TCM) effector (TEM) based on different migration behaviors cytotoxic potential. We recently discovered existence of novel subset that has unique migratory properties superior homeostatic self-renewal capacity. The hitherto...