A5081871891- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Silk-based biomaterials and applications
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Analytical Methods in Pharmaceuticals
- Interprofessional Education and Collaboration
- Curcumin's Biomedical Applications
- Lipid Membrane Structure and Behavior
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Periodontal Regeneration and Treatments
- Hydrogels: synthesis, properties, applications
- Essential Oils and Antimicrobial Activity
- Graphene and Nanomaterials Applications
- Psoriasis: Treatment and Pathogenesis
- Helicobacter pylori-related gastroenterology studies
- Chronic Myeloid Leukemia Treatments
- Ethics in medical practice
- Biological Research and Disease Studies
- Computational Drug Discovery Methods
University of Sharjah
2016-2025
Cairo University
2007-2022
National Guard Health Affairs
2022
King Abdulaziz Medical City
2022
University of Aden
2019
University of Maryland, Baltimore
2003-2008
Johns Hopkins University
2005-2007
Marine Polymer Technologies (United States)
2005
The unique advantage of genetic engineering techniques for the design and development polymers controlled gene delivery lies in exquisite control over polymer structure. In this article we report biosynthesis characterization a series new silk-elastinlike protein (SELPs), namely, SELP415K, with larger elastin blocks per monomer unit than SELP47K previously studied matrix-mediated delivery. A cloning strategy was used, where block eight units (8E) integrated into existing DNA sequence genes...
Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery DTZ. Niosomes protect hydrophilic drugs inside their core while route offers both rapid onset evasion first-pass metabolism. were prepared using combination Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed determination entrapment efficiency, particle size...
The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake lead to possible leakage the drug into systemic circulation at tumor site. In this work, ultra-high paclitaxel-loaded poly(lactide-co-glycolide) NPs (PTX-PLGA-NPs) with ultra-small sizes were prepared optimized by adopting principles quality design (QbD) approach. PTX-PLGA-NPs showed spherical particles about 53 nm EE% exceeding 90%, a relatively low polydispersity...
Triple negative breast cancer (TNBC) is the most aggressive accounting for around 15% of identified cases. TNBC lacks human epidermal growth factor receptor 2 (HER2) amplification, hormone independent estrogen (ER) and progesterone receptors (PR) negative, not reactive to current targeted therapies. Existing treatment relies on chemotherapeutic treatment, but in spite an initial response chemotherapy, inception resistance relapse unfortunately common. Dasatinib approved second-generation...
Peptide nanofibers have exhibited a remarkable ability to enhance immune response induction. Herein, we explore the peptide nanofibers' transformative potential, providing comprehensive examination of their application in vaccine development.
Intra-articular injections of hyaluronic acid (HA) and corticosteroids have been extensively used in treating temporomandibular disorders. However, rapid clearance from the site injection is a major concern that commonly managed by frequent dosing, which not without complications. This study aimed to determine suitability thermosensitive chitosan-based hydrogels for intra-articular controlled release drugs rabbit joint (TMJ). A series were prepared using different chitosan (Ch)...
Several scaffolds and cell sources are being investigated for cartilage regeneration. The aim of the study was to prepare nanocellulose-based thermosensitive injectable hydrogel assess their potential as 3D allowing chondrogenic differentiation embedded human dental pulp stem progenitor cells (hDPSCs).The hydrogel-forming solutions were prepared by adding β-glycerophosphate (GP) chitosan (CS) at different ratios. Nanocellulose (NC) suspension produced from hemp hurd then added dropwise CS/GP...