A5038580771- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Trace Elements in Health
- Extraction and Separation Processes
- Clinical Laboratory Practices and Quality Control
- Magnetism in coordination complexes
- COVID-19 Clinical Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Hypothalamic control of reproductive hormones
- Galectins and Cancer Biology
- Metal complexes synthesis and properties
- Radioactive element chemistry and processing
- Antimicrobial Peptides and Activities
- Renal Transplantation Outcomes and Treatments
- Advanced NMR Techniques and Applications
- Fungal Infections and Studies
- Blood transfusion and management
- Hormonal and reproductive studies
- Viral gastroenteritis research and epidemiology
- Drug Transport and Resistance Mechanisms
- Biochemical and Structural Characterization
- HIV/AIDS drug development and treatment
- Ovarian function and disorders
- Erythropoietin and Anemia Treatment
Tufts University
2022-2023
Tufts Medical Center
2022-2023
Johns Hopkins Medicine
2020-2021
Johns Hopkins University
2020-2021
Duke University
2015-2020
National Institute of Standards and Technology
2015
NIST Center for Neutron Research
2015
Human serum transferrin (sTf) is a protein that mediates the transport of iron from blood to cells. Assisted by synergistic anion carbonate, sTf transports Fe(III) binding metal ion in closed conformation. Previous studies suggest sTf's role as potential transporter other metals such titanium. Ti widely used colorants, foods, and implants. A substantial amount leached into these However, fate its cells not known. Understanding interaction with assumes greater significance our ever increasing...
Rapid point-of-care tests (POCTs) for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies vary in performance. A critical need exists to perform head-to-head comparisons these assays.
The histidine-rich salivary peptides of the histatin family are known to bind copper (Cu) and other metal ions in vitro; however, details these interactions poorly understood, their implications for vivo antifungal activity have not been established. Here, we show that availability Cu during exposure Candida albicans histatin-5 (Hist-5) modulates its activity. Antifungal susceptibility testing revealed co-treatment Hist-5 with improved EC50 from ∼5 ∼1 μM, whereas a high-affinity Cu-specific...
Rapid point-of-care tests (POCTs) for SARS-CoV-2-specific antibodies vary in performance. A critical need exists to perform head-to-head comparison of these assays. Performance fifteen different lateral flow POCTs the detection was performed on a well characterized set 100 samples. Of these, 40 samples from known SARS-CoV-2-infected, convalescent individuals (average 45 days post symptom onset) were used assess sensitivity. Sixty pre-pandemic era (negative control), that have been infected...
This paper summarizes 0 to 0.6 GPa neutron diffraction measurements of a nickel hexacyanochromate coordination polymer (NiCrPB) that has the face-centered-cubic, Prussian blue structure. Deuterated powders NiCrPB contain $\ensuremath{\approx}100$-nm-sided cubic particles. The application large magnetic field shows ambient-pressure, saturated Pressures less than 1 have previously been shown decrease susceptibility by as much half, and we find modifications nuclear crystal structure at these...
Therapeutic plasma exchange (TPE) removes both pathologic and protective immunoglobulins (Ig). SARS-CoV-2 immunity is partially mediated by anti-SARS-CoV-2 spike antibodies (SAb), which impair viral host-cell invasion. Nonetheless, the systematic effect of TPE on SAb concentration unknown.Paired waste specimens from first (first-TPE) last (last-TPE) treatment were collected 9 patients between July 21, 2021 March 1, 2022. The effects Ig levels assessed quantitatively comparing SAb, total IgG,...