A5074397578- Lymphoma Diagnosis and Treatment
- Lattice Boltzmann Simulation Studies
- Chronic Lymphocytic Leukemia Research
- Fluid Dynamics Simulations and Interactions
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Computational Fluid Dynamics and Aerodynamics
- Micro and Nano Robotics
- Numerical methods in engineering
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Digital Imaging for Blood Diseases
- Erythrocyte Function and Pathophysiology
- Composite Material Mechanics
- Fluid Dynamics and Vibration Analysis
- CNS Lymphoma Diagnosis and Treatment
- Educational Robotics and Engineering
- Blood Coagulation and Thrombosis Mechanisms
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Thermal Regulation in Medicine
- Blood Pressure and Hypertension Studies
Juntendo University Urayasu Hospital
2013-2025
The University of Tokyo
1999-2024
National Institute of Advanced Industrial Science and Technology
2012-2024
Tosei General Hospital
2020
Tokyo Institute of Technology
2015
Juntendo University
2013-2014
Aichi Prefectural University
2009
Kitami Institute of Technology
2004
Center for Biologics Evaluation and Research
1997
Kumamoto University
1991-1992
Background: To elucidate the mechanisms of resistance to treatment in patients with acute myeloid leukemia (AML) except for M3 so as devise ways overcome them and improve outcomes. Methods: For this study, we randomly selected 35 AML who had received combined cytarabine plus idarubicin new-onset at our hospital. Expressions 23 treatment-resistance-related proteins biopsy specimens were evaluated by immunohistochemical staining using corresponding antibodies, followed retrospective analysis...
Background: This study was aimed at elucidating the mechanisms underlying development of treatment resistance in patients with acute myeloid leukemia (AML) other than M3 order to devise ways overcome and improve outcomes these patients. Methods: For this study, we randomly selected 35 AML who had received combined cytarabine plus idarubicin for new-onset our hospital. We performed immunohistochemical analysis biopsy specimens obtained from investigate expressions 23...
It is well known that disorders of coagulation and fibrinolysis play a major role in the development organ dysfunction during sepsis. Furthermore, importance early initiation anticoagulation therapy for severe cases has been emphasized based on success recent clinical trials. The purpose this study to search useful markers predicting dysfunction. Plasma samples were prospectively collected from 78 patients within 48 h after onset Hemostatic endothelial damage compared between with without...
Activation of macrophages by LPS and taxol results in production IL-1, IL-6, TNF-alpha, granulocyte-macrophage CSF (GM-CSF), which are involved regulating hemopoiesis, inflammation, immune responses. Microtubules proposed as a target site for interaction(s), based on similarities between the effects tubulin-binding drug LPS. To clarify role microtubules LPS-induced GM-CSF expression macrophages, we examined whether microtubule depolymerizing agents affect macrophages. Pretreatment with...
Abstract A scalable matrix solver was developed for the moving particle hydrodynamics incompressible flows (MPH-I) method. Since MPH-I method can calculate both and highly viscous while ensuring stability through physical consistency, a wide range of industrial applications is expected. However, in its implicit calculation, pressure velocity must be solved simultaneously via linear equation with nondefinite symmetric coefficient matrix. In this study, system converted into positive definite...
We conducted this study with the objective of elucidating mechanism development fibrosis in hematologic neoplasms and develop treatments for these patients. Among suggested mechanisms is cases production TGF-beta1 (transforming growth factor-beta-1) TNF-alpha1 (tumor necrotizing factor-alpha-1) by tumor cells, both which are fibrosis-stimulating cytokines that act on fibroblasts to promote fibrosis. However, there few reports based human clinical pathology studies. an immunohistochemical...
Large Language Models (LLMs) have demonstrated remarkable performance on various quantitative reasoning and knowledge benchmarks. However, many of these benchmarks are losing utility as LLMs get increasingly high scores, despite not yet reaching expert in domains. We introduce ARB, a novel benchmark composed advanced problems multiple fields. ARB presents more challenging test than prior benchmarks, featuring mathematics, physics, biology, chemistry, law. As subset we set math physics which...
Despite the increasing threat of heatstroke with global warming, pathophysiologic injury continues to be defined. In addition, morphological changes peripheral blood cells in have not been well characterized. We evaluated bone marrow and a rat model using 39.5 °C climate chamber. After three hours incubation, samples were collected for morphology, direct effects heat on leukocytes vitro time-lapse observation. The cell count peripheral/bone smear examined either lethal (core body temperature...
We conducted a retrospective analysis of GRP94 immunohistochemical (IHC) staining, an ER stress protein, on large B-cell lymphoma (LBCL) cells, intracellular p53, and 15 factors involved in the metabolism CHOP regimen: AKR1C3 (HO metabolism), CYP3A4 (CHOP HO efflux pumps (MDR1 MRP1). The study subjects were 42 patients with LBCL at our hospital. IHC staining used antibodies against 17 factors. odds ratios by logistic regression dichotomous variable CR non-CR/relapse statistically significant...
Background: Aggressive mature T-cell lymphoma (TCL) is a disease that carries poor prognosis. Methods: We analyzed the expression of 22 tumor cell functional proteins in 16 randomly selected patients with TCL. Immunohistochemistry was performed paraffin-embedded tissue sections to determine protein statuses cells. Results: Glucose-regulated 94 (GRP94), serves as pro-survival component under endoplasmic reticulum (ER) stress microenvironment, significantly associated shortened survival....
Abstract This paper presents an alternative choice for the construction of integration cells and additional Lagrange‐multiplier mesh in computations using eXtended finite element method (X‐FEM) with Lagrange‐multiplier. The proposed computational target is flow simulations Dirichlet boundary conditions on a non‐boundary‐fitted mesh. methods studied this make use high‐order Gaussian quadrature to relax complexity implementing X‐FEM first these straightforward employment as numerical scheme...