A5044448169- Innovative Teaching Methods
- Problem and Project Based Learning
- Cytokine Signaling Pathways and Interactions
- Biomedical and Engineering Education
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Antimicrobial Resistance in Staphylococcus
- Lipoproteins and Cardiovascular Health
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- CAR-T cell therapy research
- Education and Critical Thinking Development
- Pharmacological Effects of Natural Compounds
- Microbial Metabolism and Applications
- NF-κB Signaling Pathways
- Infective Endocarditis Diagnosis and Management
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Biochemical and Structural Characterization
- Neonatal and Maternal Infections
- Higher Education Practises and Engagement
- S100 Proteins and Annexins
- Psoriasis: Treatment and Pathogenesis
University of Alabama at Birmingham
2019-2024
Ball State University
2005-2019
District of Columbia Public School
2017
Walther Cancer Foundation
2000-2007
Indiana University – Purdue University Indianapolis
2000-2007
Indiana University School of Medicine
2000-2007
Universitätsklinikum Erlangen
2007
Abstract Stat4 is activated in response to IL-12. Most functions of IL-12, including the induction IFN-γ, are compromised absence Stat4. Since precise role IFN-γ has not been established, experiments were conducted examine activation and other genes required for cytokine-induced expression IFN-γ. We first examined IL-12 signaling components. Basal IL-12Rβ1 IL-12Rβ2 decreased Stat4-deficient cells compared with that control cells. However, was still capable inducing equivalent phosphorylation...
Abstract IL-4 is a critical cytokine in the regulation of immune responses and genesis atopy. Engagement IL-4R activates multiple signaling pathways, including transcription factor Stat6. Stat6-deficient mice demonstrate importance this lymphocyte proliferation, gene expression, Th cell differentiation. Recently, mutant Stat6 (Stat6VT) was generated that transcriptionally active independent stimulation. To determine ability constitutively to mimic IL-4-stimulated responses, we have...
IL-4 is required for the pathogenesis of atopic diseases and immune regulation. Stat6 critical IL-4-induced gene expression Th cell differentiation. Recently, we have generated mice expressing a mutant (Stat6VT) under control CD2 locus region that transcriptionally active independent stimulation. To determine whether in T cells sufficient to alter regulation vivo, mated Stat6VT transgenic IL-4-deficient mice. lymphocytes was lymphocyte homeostasis promote Th2 differentiation vitro. HyperTh2...
Abstract Over the last few decades, there has been a shift in classroom from lecture‐based to active learning settings with argument that students retain more information when they are involved process. This correlation is even stronger setting incorporates real‐world or personal connection. Using activities develop students' ability comprehend primary scientific literature particularly important field of immunology, due rapid expansion field, which further accelerated COVID‐19 pandemic. By...
Immunology has its developmental roots in understanding protection of the host from pathogens, leading to development vaccines and subsequently identification soluble cellular components immune system. Thus, immunology education historically been tightly linked infectious disease. Decades research have demonstrated that complexity intricacies system are far greater than perhaps was once imagined. As a interfaces with all other organ systems body, it plays key role both maintaining health...
Abstract IL-4 is a critical cytokine in the regulation of immune responses. In B lymphocytes, signaling promotes Stat6-dependent cell surface expression several proteins including MHC Class II and CD86. However, requirement for other transcription factors IL-4-induced gene has not been studied extensively. Here, we show that induces NF-κB p100 processing to p52 cells but T or macrophages. induced production requires PI-3K activity correlates with IκB kinase phosphorylation TNF...
Immunology is inherently interdisciplinary. Understanding how the immune system functions requires knowledge from several scientific disciplines, including molecular biology, cellular genetics, and biochemistry. Furthermore, immunology conceptually complex, requiring identification of a plethora components mastery large volume new vocabulary. These attributes can pose challenges to student learning in undergraduate classroom. Team-based (TBL) pedagogical method used increase engagement...
Abstract Th17 cells are critical for the clearance of extracellular bacteria and fungi, but also contribute to pathology autoimmune diseases allergic inflammation. After exposure an appropriate cytokine environment, can acquire a Th1-like phenotype, less is known about their ability adopt Th2 Th9 effector programs. To explore this in more detail, we used IL-17F lineage tracer mouse strain that allows tracking formerly expressed IL-17F. In vitro–derived adopted signature transcription factor...
Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept that prognosis worsens when the infecting S. strain has capacity to not only colonize tissue as an extracellular pathogen, but invade host cells establish intracellular bacterial populations. In previous work, we identified CDC42 central regulator of endothelial cell invasion by aureus. current report ML 141, first-in-class inhibitor, decreases resultant pathogenesis dose-dependent...
Although immunological research has become increasingly important in recent decades for understanding infectious and immune-mediated diseases, pedagogy at the undergraduate level lagged behind reports of evidence-based scholarship. To address need a renewed emphasis on immunology education to describe current status immunology, an online survey instructors with experience teaching was conducted.
The interdisciplinary nature of immunology can make studying not only engaging but also challenging, as understanding immunologic processes and immune system components requires foundational knowledge from several science disciplines. University Alabama at Birmingham has a unique, 4-year, Undergraduate Immunology Program (UIP) that provides comprehensive curriculum in includes five core courses starting the second year, which point, students are process completing basic sequences. For this...
Immune literacy garnered significant attention in recent years due to the threat posed by emerging infectious diseases. The pace of immunological discoveries and their relevance society are substantial yet coordinated educational efforts have been rare. This motivated us create a task force educators reflect on pedagogical approaches teaching immunology draft, develop, evaluate key competencies for undergraduate education. research questions addressed include: 1) Which considered important...
The field of immunology is rapidly evolving and has significant relevance to understanding human health, particularly in light the threat from infectious diseases ability harness immune system treat cancer, autoimmune diseases, allergies. Providing opportunities explore relevant undergraduate students interested pursuing careers health professions biomedical research. There are calls for greater emphasis on interdisciplinary science education at level acquisition transferrable competencies...
Statins are potent modulators of immune responses, resulting in their ability to enhance host survival from primary bacterial infections. Alterations responses that may be beneficial for following infection also result alterations the generation immunologic memory response and subsequently affect mounted during secondary infection. In this study, we report levels total serum IgG2c, infection, were decreased simvastatin pretreated mice, investigate effect treatment, prior on activated S....
Staphylococcus aureus is the most prevalent etiologic agent of sepsis.Statins, primarily prescribed for their cholesterol-lowering capabilities, may be beneficial treating sepsis due to antiinflammatory properties.This study examined effect low dose, short term simvastatin pretreatment in conjunction with antibiotic treatment on host survival and demonstrated that increased C57BL/6 mice response S. infection.In vitro studies revealed did not reduce aureus-stimulated expression surface...
Two hundred and two (n = 202) sixth‐grade students in social studies were administered a weekly vocabulary‐matching curriculum‐based measure (CBM) for 35 weeks. Students also the Scholastic Reading Inventory (SRI), along with annual state high‐stakes test Communication Arts. CBM scores analyzed respect to alternate form reliability, validity criterion measures, student growth over time. Results suggest that is reliable valid SRI but not test. showed an overall linear trend of growth, this...
Recurrent pharyngotonsillitis due to Streptococcus pyogenes develops regardless of whether infecting strains are resistant or susceptible first-line antimicrobials. Causation for recurrent infection is associated with the use antimicrobials that fail penetrate deep tissue and host cell membranes, enabling intracellular S. survive throughout repeated rounds antimicrobial therapy.To determine simvastatin, a therapeutic approved in treatment hypercholesterolemia, ML141, first-in-class small...
Staphylococcus aureus is the most prevalent etiologic agent of sepsis. Statins, primarily prescribed for their cholesterol-lowering capabilities, may be beneficial treating sepsis due to anti-inflammatory properties. This study examined effect low dose, short term simvastatin pretreatment in conjunction with antibiotic treatment on host survival and demonstrated that increased C57BL/6 mice response S. infection. In vitro studies revealed did not reduce aureus-stimulated expression surface...