A5027945631- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Polyomavirus and related diseases
- Multiple Sclerosis Research Studies
- Heat shock proteins research
- Peripheral Neuropathies and Disorders
- Immunodeficiency and Autoimmune Disorders
- Peroxisome Proliferator-Activated Receptors
- Fetal and Pediatric Neurological Disorders
- Myasthenia Gravis and Thymoma
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Childhood Cancer Survivors' Quality of Life
- Cell Adhesion Molecules Research
- Family Support in Illness
- Brain Metastases and Treatment
- Genetic Neurodegenerative Diseases
- Advanced Biosensing Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Adolescent and Pediatric Healthcare
- Insect Resistance and Genetics
- Lymphoma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
University of Utah
2017-2024
University of Oklahoma Health Sciences Center
2018
University of Oklahoma
2017
University of British Columbia
2006
BC Cancer Agency
2005
Abstract Synovial sarcoma is a soft tissue malignancy with poor prognosis; many patients will die from this disease within 10 years of diagnosis, despite treatment. Gene expression profiling and immunohistochemistry studies have identified oncogenes that are highly expressed in synovial sarcoma. Included group receptor tyrosine kinases such as epidermal growth factor receptor, insulin-like 1, fibroblast 3, KIT, HER2. Inhibitors these growth-promoting receptors likely to inhibit proliferation...
Background Mitchell syndrome is a rare, neurodegenerative disease caused by an ACOX1 gain-of-function mutation (c.710A>G; p.N237S), with fewer than 20 reported cases. Affected patients present leukodystrophy, seizures, and hearing loss. serves as the rate-limiting enzyme in peroxisomal beta-oxidation of very long-chain fatty acids. The N237S substitution has been shown to stabilize active dimer, resulting dysregulated enzymatic activity, increased oxidative stress, glial damage. lacks...
Abstract Objective To describe patient clinical characteristics associated with matched oligoclonal bands (OCB). Methods A retrospective review at the University of Utah examined patients OCB from 2015 to 2020. Clinical data, diagnosis, and outcomes were collected. Patients classified either multiple sclerosis (MS), other inflammatory neurologic disorder (other‐IND), or noninflammatory (NIND). Results Of 539 identified patients, 436 (53.4% female) matched‐only, while 103 (43.7% + unique....
<h3>Objective:</h3> To describe the progression of symptoms, diagnostic testing, and encounters with health care system that pediatric patients experience prior to receiving a confirmed diagnosis anti-NMDAR encephalitis. <h3>Background:</h3> Prompt treatment encephalitis in is associated improved outcomes, but remains challenging. Heterogeneity presentations, variability based on age, broad differential diagnoses symptoms population can complicate timely accurate identification disease....
April 23, 2018April 10, 2018Free AccessInteraction of Normal and Antineuronal IgGs with Neurons in Rat Brain Slice Cultures: Comparison IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, Production Neuronal Death (P2.403)John Greenlee, Susan Clawson, Kenneth Hill, Blair Wood, Suzanne Liu, Stacey Clardy, Noel CarlsonAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P2.403 Letters the Editor
<h3>Objective</h3> To describe the characteristics and outcomes in adult pediatric patients diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at two major referral centers Mountain West of United States, a geographic area encompassing roughly 15% land mass continental US. <h3>Background</h3> Since development commercial assays, MOGAD has become increasingly recognized as an etiologic diagnosis for several CNS demyelinating phenotypes, yet epidemiological...
<h3>Objective</h3> To investigate the mechanisms by which neurons take up paraneoplastic and other antibodies. <h3>Background</h3> Our laboratory has previously demonstrated that can both normal IgGs autoantibodies such as anti-Yo anti-Hu bind to their intracellular target antigens produce neuronal death. In this study we investigated how antibody uptake occurs. <h3>Design/Methods</h3> We first compared of Fab fragments with IgG Fc or whole IgGs. determine whether expressed receptors capable...
<h3>Objective</h3> Describe a case of NMDAR encephalitis in young Latino male patient, additionally the factors resulting delayed preventative and diagnostic medical care, which contributed to development preventable encephalitis. <h3>Background</h3> Adolescent undocumented immigrants United States face history prejudice bias that perpetuates disparities stigmas related their healthcare. The lack culturally informed practices among healthcare workers can create multiple lost opportunities...
To describe the characteristics and outcomes in adult pediatric patients diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at two major referral centers Mountain West of United States, a geographic area encompassing roughly 15% land mass continental US.
Objective: Pediatric demyelinating diseases can present similarly but have different etiologies requiring distinct therapies, leaving practitioners to rely heavily on imaging guide initial treatment. We describe a patient whose symptoms, age, gender, and were consistent with cerebral X-linked adrenoleukodystrophy (ALD) was considered for bone marrow transplantation (BMT). However, complete evaluation led diagnosis of multiple sclerosis. Background: A 13 year old male presented subacute...