A5039002196- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Parathyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Eosinophilic Disorders and Syndromes
- Cardiac electrophysiology and arrhythmias
- Blood Coagulation and Thrombosis Mechanisms
- Genomics and Rare Diseases
- Congenital heart defects research
- Lipoproteins and Cardiovascular Health
- Protein Kinase Regulation and GTPase Signaling
- Ovarian cancer diagnosis and treatment
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood disorders and treatments
Aarhus University Hospital
2012-2025
Aarhus University
2012-2022
Regional Hospital Horsens
2016
Truncating variants in titin (TTNtv) are the most common cause of dilated cardiomyopathy (DCM). We evaluated genotype-phenotype correlation TTNtv-DCM, with a special focus on long-term outcomes, arrhythmias, response to treatment and sex-related presentation.Data patient characteristics outcomes were collected retrospectively from electronic health records patients genotyped at two Danish heart transplantation centres.We included 115 (66% men). At diagnosis DCM, mean age was 46±13 years left...
Wild-type transthyretin cardiac amyloidosis (ATTRwt) is an infiltrative cardiomyopathy with a poor prognosis. The condition associated carpal tunnel syndrome (CTS), which often precedes the ATTRwt diagnosis by several years. aim of study was (i) to screen patients recent history CTS for using red flags, (ii) determine whether screened had less advanced disease compared clinical ATTRwt, and (iii) assess sensitivity specificity known flags in ATTRwt.Patients aged ≥60 years at time surgery were...
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A 47-year-old woman had been treated with high-dose simvastatin for several years. After systemic treatment the antifungal agent itraconazole, she developed muscle pain and highly elevated levels of creatine kinase myoglobin. Muscle biopsy was compatible statin-associated rhabdomyolysis, probably caused by a drug–drug interaction between itraconazole. The patient made full recovery. Three commonly used statins—simvastatin, atorvastatin lovastatin—are metabolised liver enzyme CYP3A4. Several...
Prognostic markers of survival have been identified in wild-type transthyretin amyloidosis (ATTRwt), but limited data exist with respect to hospitalizations worsening heart failure (WHF). Predictive WHF yet be identified.From April 2017 February 2021, 104 patients ATTRwt were diagnosed and prospectively followed from the time diagnosis death or censoring date 1 2021. Baseline patient characteristics, biomarkers, advanced echocardiography used predict hospitalization WHF.During median...
Abstract Background The comprehensive impact of septal reduction therapy in patients with obstructive hypertrophic cardiomyopathy (HCM), including exercise hemodynamics and quality life (QoL), remains poorly understood. Purpose aim this study was to evaluate the effect alcohol ablation (ASA) mitigating left ventricular outflow tract (LVOT) obstruction, reducing filling pressures during exercise, on QoL HCM. Methods This prospective enrolled 24 HCM referred for ASA. Evaluations included...
Abstract Aim To investigate if asymptomatic relatives carrying genetic variants associated with familial dilated cardiomyopathy (DCM) show early signs of myocardial disease assessed by echocardiography. Methods and Results Asymptomatic without a DCM-phenotype (n=176, 46% males, mean age 39 years ± 16) 111 DCM index patients likely pathogenic or pathogenetic in TTN, RBM20, FLNC genes were recruited from two tertiary referral centers for inherited cardiac diseases. All participants underwent...
Abstract Aims Wild‐type transthyretin cardiac amyloidosis (ATTRwt) is a cardiomyopathy causing myocardial hypoperfusion and impaired mitochondrial function. Trimetazidine an antianginal agent used in patients with stable angina pectoris, which improves contractility The aim of the study was to investigate effect trimetazidine on invasive haemodynamics function ATTRwt. Methods In randomized, double‐blind, placebo‐controlled, crossover trial, 22 ATTRwt received 4 weeks placebo randomized...
Genotyping divides transthyretin cardiac amyloidosis (ATTR-CA) in hereditary (ATTRv) and wild type (ATTRwt) forms. This study investigated the prevalence clinical presentation of ATTRv a contemporary cohort consecutive ATTR-CA patients diagnosed at tertiary Danish center. Age diagnosis, clinical- echocardiographic data, (TTR) genotype were recorded. Relatives underwent phenotyping predictive gene testing. Genetic testing 102 identified four TTR variant carriers: p.Pro63Ser, p.Ala65Ser (n =...
Abstract Purpose To investigate the prevalence of mATTR in a cohort consecutive ATTR patients tertiary Danish Amyloidosis Center. Methods Consecutive period from 2001 to 2019 with definite diagnosis ATTR-CA or ATTR-FAP based on either 99-Tc-DPD-scintigraphy, transthyretin deposition myocardium fatty tissue proved by immunohistology protein mass spectrometry underwent testing for exonic genetic TTR variants. The distributions age at time and wildtype (wtATTR) are described mean age, standard...
Abstract Background Treatment with beta blockers (BB) has been used for symptomatic relief in patients obstructive hypertrophic cardiomyopathy (HCM) decades. Even so, the guideline recommendation use of BB rests on expert opinions and observational cohort studies. Providing comprehensive high-quality data effects HCM is essential, especially context newly developed pharmacological treatment strategies specifically targeting this disease (1). Purpose The study aimed to investigate metoprolol...
Abstract Background Truncating genetic variants in titin (TTNtv) are identified 15–25% of patients with primary dilated cardiomyopathy (DCM). Previous genotype/phenotype studies have reported conflicting results regarding disease severity and pathologic features associated TTNtv. Purpose To investigate the natural history, reversibility burden arrhythmias TTNtv a Danish cohort long-term follow-up. Methods Patients DCM, recruited from two tertiary centers, were included based on presence...
Abstract Background A substantial number of elderly patients with aortic stenosis (AS) have been reported to coexisting transthyretin cardiac amyloidosis (ATTR). These are characterized by advanced heart failure symptoms and increased NTproBNP. Raising clinical suspicion ATTR in AS seems difficult. Recent data has shown that an apical-basal strain ratio (ABr) derived echocardiography predicts the diagnosis (CA) left ventricular (LV) hypertrophy. However, prevalence prognostic value ABr, a...
Abstract Background Hypertrophic cardiomyopathy (HCM) patients with outflow obstruction often experience symptoms of heart failure upon exertion. We aimed to characterize left ventricular (LV) systolic function by segmental and global longitudinal strain echocardiography, investigate changes in relation exercise, the effect standard treatment beta-blockers. Method Twenty-nine obstructive HCM New York Heart Association (NYHA) class ≥ II were enrolled a double-blind, placebo-controlled,...
Introduction: Patients with obstructive hypertrophic cardiomyopathy (HCM) frequently experience advanced heart failure symptoms at low levels of physical activity. The relationship between and loading conditions during exercise is incompletely understood. Whether standard treatment beta-blockers affects hemodynamics unknown. Objectives: aim this study was to investigate the invasive hemodynamic response in moderately symptomatic patients HCM, how metoprolol response. Method: This...