A5000482287- Biomedical Ethics and Regulation
- Pluripotent Stem Cells Research
- Science, Research, and Medicine
- Ethics in Clinical Research
- CRISPR and Genetic Engineering
- Neuroethics, Human Enhancement, Biomedical Innovations
- Biotechnology and Related Fields
- Environmental and Social Impact Assessments
- Ethics and Social Impacts of AI
- Biomedical and Engineering Education
- Genetically Modified Organisms Research
- EEG and Brain-Computer Interfaces
- Reproductive Health and Technologies
- Technology and Data Analysis
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Color perception and design
- Dermatologic Treatments and Research
- Online and Blended Learning
- CAR-T cell therapy research
- 3D Printing in Biomedical Research
- Organizational Learning and Leadership
- Innovative Approaches in Technology and Social Development
- Sustainability and Climate Change Governance
- Complex Systems and Decision Making
De Montfort University
2021-2024
University of Exeter
2018-2023
Leverhulme Trust
2023
University of Cambridge
2023
University of Sussex
2011-2019
University of Warwick
2015-2018
Children's Clinical University Hospital
2006
Uniwersytecki Szpital Dziecięcy
2006
Drawing on more than eight years working to implement Responsible Research and Innovation (RRI) in the Human Brain Project, a large EU-funded research project that brings together neuroscience, computing, social sciences, humanities, one of largest investments RRI project, this article offers insights explores its possible future. We focus question how can have long-lasting impact persist beyond time horizon funded projects. For purpose, we suggest concept 'responsibility by design' which is...
Abstract Despite its successes, to date Artificial Intelligence (AI) is still characterized by a number of shortcomings with regards different application domains and goals. These limitations are arguably both conceptual (e.g., related the underlying theoretical models, such as symbolic vs.connectionist), operational robustness ability generalize). Biologically inspired AI, more specifically brain-inspired promises provide further biological aspects beyond those that already traditionally...
regulation indicates an important step toward the improved governance and review of stem cell clinical research applications in China.
A very large grey area exists between translational stem cell research and applications that comply with the ideals of randomised control trials good laboratory clinical practice what is often referred to as snake-oil trade. We identify a discrepancy international ethics regulation ways in which regulatory instruments field are developed practice. examine this using notion 'national home-keeping', referring way governments articulate standards conflicting demands on local players at home....
This essay is the starting point of a new column in Intelligent Medicine that invites interdisciplinary perspectives on social, ethical, legal, and responsibility aspects use artificial intelligence (AI) medicine health care. Papers this will examine practical, conceptual, policy dimensions AI for health-related purposes from comparative international perspectives. We invite contributions around world all application areas health, including care, research, drug development, care system...
In this article, we explore regulatory developments in stem cell medicine seven jurisdictions: Japan, China, India, Argentina, Brazil, the USA and EU. We will show that research methods, ethical standards approval procedures for market use of clinical interventions are undergoing an important process global diversification. discuss implications international harmonization conduct multicountry collaborations. It become clear increasing heterogeneity regulations field presents a significant...
The article explores the formation of an international politics resistance and ‘alter-standardization’ in regenerative stem cell medicine. absence internationally harmonized regulatory frameworks clinical field presence lucrative business opportunities have resulted transnational networks adopting alternative research standards practices. These oppose, as a universal global standard, strict evidence-based medicine protocols defined by scientists agencies highly developed countries. emergence...
Stem cell research has been acclaimed to revolutionize the future of medicine, and offer new treatments for previously incurable diseases. Despite years research, however, therapeutic potential stem not yet fully realized. By June 2014, US Food Drug Administration had approved only five cell-based medicinal products, all which cord blood derived hematopoietic products cure immunological Anticipated cancer, neurodegenerative disorders, gastroenterological, myocardial, other diseases are still...
Abstract A central problem for the international governance of heritable germline gene editing is that there are important differences in attitudes and values as well ethical health care considerations around world. These reflected a complicated diverse regulatory landscape. Several publications have discussed whether reproductive uses would be legally permissible individual countries clinical applications could emerge context gaps gray areas. Systematic comparative studies explore issues...
The article examines the role and challenges of scientific self-governance standardization in inter-continental clinical research partnerships stem cell medicine. paper shows that - due to a high level regulatory diversity enactment internationally recognized standards multi-country trials is complex highly situation-specific achievement. Standardization imposed on background regulatory, institutional epistemic-cultural heterogeneity, implemented exclusively context select projects. Based...
The international landscape of medical research is in the midst a process diversification and change. randomized controlled trial (RCT), long considered global gold standard for clinical research, has become increasingly contested partly replaced by alternative methodologies, standards forms evidence. contours mainstream are changing as result. Regulatory paradigms are, literally, being rewritten, at level. evidence-based medicine (EBM) hierarchy evidence redefined. This special issue...
Bioethical debates on the use of human embryos and oocytes for stem cell research have often been criticized lack empirical insights into perceptions experiences women couples who are asked to donate these tissues in IVF clinic. Empirical studies that investigated attitudes patients citizens (potential) donation their scarce focused predominantly situation Europe Australia. This article examines viewpoints among students China. Research is based in-depth interviews with clinicians. a...
This paper examines the notion of capability development through lens Responsible Research and Innovation (RRI). It describes how RRI capabilities can be promoted developed capacity-building activities by drawing on a reflection experiences some members Ethics Society team EU-funded Human Brain Project (HBP) who have contributed to an extensive capacity building programme for HBP researchers, EBRAINS research infrastructure developers users, as well interested external audiences. also...
Summary It has increasingly been acknowledged that only a few leukaemic cells possess the capability to renew themselves and these self‐renewing stem are able initiate relapses. Therefore, should be target for therapy minimal residual disease (MRD) detection. Because of its presence on blasts 11q23‐rearranged high‐risk patients, neuron‐glial antigen 2 (NG2) is thought valuable marker detecting cells. Six acute myeloid leukaemia (AML)/abn(11q23) three lymphoblastic (ALL)/t(4;11) samples were...
Medicine regulation worldwide has undergone a process of regulatory diversification. The evidence-based medicine (EBM) paradigm, centered on multi-phase randomized controlled trials, is increasingly contested and replaced by new models clinical validation. To explain these changes, STS research cited just few factors, e.g. growing pressure form health consumers; the role pharmaceutical companies to lobby for fast, affordable drug development; influence neoliberal ideas libertarian advocacy...
The donation of embryos for human embryonic stem cell (hESC) research is commonly framed as an act solidarity, exemplifying a selfless expression help from present-day citizens public health improvements in the future. As I will show at case hESC People's Republic China, however, such discourse conceals complexities contemporary distribution and exchange systems, well concrete forms value benefit that derivation, use circulation these tissues has user communities already here now. While it...
Abstract This paper aims to analyze innovation pathways for stem cell technology in Argentina. Firstly, we present a theoretical perspective on the co-construction of regulation and development, positing four main tensions that underlie regulatory building shaping national strategies regenerative medicine. Regulation is understood as negotiated process among interests, values, benefits, rewards, different understandings safety, efficacy, access availability. The framework useful explore how...
Recent years have seen the uptake of challenge and mission-oriented innovation policies in Europe, including UK. These developments been paralleled by variable support for responsible research (RRI) policies. This article explores adoption challenge-driven strategies UK's industrial biotech (IB) sector alongside RRI expectations, examining effects implications. Drawing on analysis IB policy documents interview data, we argue that articulation aims terms grand challenges provides stakeholders...
While other works have explained difficulties in applying 'international' guidelines the field of regenerative medicine so-called low- and middle-income countries (LMICs) terms 'international hegemony', 'political ethical governance' 'cosmopolitisation', this article on stem cell regulation China emphasizes particular complexities faced by large LMICs: emergence alternative regulatory arrangements made stakeholders at a provincial level home. On basis ethnographic archival research clinical...
The article explores the contemporary dynamics of global scientific multipolarisation, and empirical theoretical implications this trend for international clinical research collaborations. focal point is an ethnographic study China Spinal Cord Injury Network (China SCI Net), a transcontinental infrastructure that active in Mainland China, Hong Kong, Taiwan US. Based on findings from case study, author suggests transition toward multipolarising science world associated with significant...