A5102872329- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Transplantation: Methods and Outcomes
- Cytokine Signaling Pathways and Interactions
- Sarcoma Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Viral-associated cancers and disorders
- Pluripotent Stem Cells Research
- Reproductive tract infections research
- Tissue Engineering and Regenerative Medicine
- Brain Metastases and Treatment
Cedars-Sinai Medical Center
2022-2025
Johns Hopkins University
2017-2024
Johns Hopkins Medicine
2017-2024
Cancer Research Center
2017-2024
Jefferson Hospital for Neuroscience
2013
Thomas Jefferson University
2013
Van Andel Institute
2012
Constitutive activation of STAT3 is a common feature in many solid tumors including non-small cell lung carcinoma (NSCLC). While commonly achieved by somatic mutations to JAK2 hematologic malignancies, similar are not often found tumors. Previous work has instead suggested that more induced hyperactive growth factor receptors or autocrine cytokine signaling. The interplay between and other well-characterized oncogenic “driver” NSCLC been fully characterized, though constitutive proposed play...
PurposeWe assessed the feasibility and theoretical dosimetric advantages of an injectable hydrogel to increase space between head pancreas (HOP) duodenum in a human cadaveric model.Methods MaterialsUsing 3 specimens, absorbable radiopaque was injected HOP by way open laparotomy 1 case endoscopic ultrasound (EUS) guidance 2 cases. The cadavers were subsequently imaged using computed tomography dissected for histologic confirmation placement. duodenal dose reduction planning target volume...
Intraductal papillary mucinous neoplasms (IPMNs) are commonly identified non-invasive cyst-forming pancreatic with the potential to progress into invasive adenocarcinoma. There few in vitro models which study biology of IPMNs and their progression carcinoma. Therefore, we generated a living biobank organoids from seven normal ducts ten IPMNs. We characterized eight IPMN organoid samples using whole genome sequencing five duct transcriptome sequencing. an average 11,344 somatic mutations...
Objectives. To determine the accuracy of grading pancreatic well-differentiated neuroendocrine tumors (PanNETs) on endoscopic ultrasound-guided fine needle biopsy (EUS-FNB). Methods. Fifty-three (53) PanNETs from 52 patients with EUS-FNB and subsequent resection were included, including 1 patient 2 synchronous biopsied separately. Grade (G) was assigned as per 2019 World Health Organization criteria. The concordance grade between measured using kappa statistic. Clinicopathologic features...
Invasive pancreatic ductal adenocarcinoma (PDAC) can infiltrate back into and spread along preexisting ducts ductules in a process known as cancerization of (COD). Histologically COD mimic high-grade intraepithelial neoplasia (HG-PanIN). We reviewed resections from 100 patients with PDAC for the presence or absence histologic features COD. Features supporting included adjacent histologically similar invasive an abrupt transition between markedly atypical intraductal epithelium normal duct...
Germline pathogenic variants in the ATM serine/threonine kinase (ATM) gene are associated with an increased risk of pancreatic ductal adenocarcinoma. It is important to identify germline cancer patients because these alterations potentially targetable chemotherapeutic drugs and/or radiation and have implications for other family members. As genes been distinct histologic subtypes cancer, we studied histomorphology 23 variants. The subtype was adenocarcinoma 19/23 (83%) patients,...
Although prevalent in 50%-90% of pancreatic ductal adenocarcinomas, the clinical relevance "cancerization ducts" (COD) remains unknown.
Abstract Understanding the timing and spectrum of genetic alterations that contribute to development pancreatic cancer is essential for effective interventions treatments. The aim this study was characterize somatic ATM in noninvasive precursor lesions invasive adenocarcinomas from patients with without pathogenic germline variants. DNA isolated sequenced ductal a variant. Tumor these as well colloid carcinoma variant were immunolabeled assess expression. Among variant, alterations, either...
Capecitabine is a commonly used oral chemotherapeutic agent. Gastrointestinal (GI) side effects are clinically well-known, however, the histopathologic changes have not been comprehensively studied. This study describes largest case series (8 patients) characterizing histopathology of capecitabine-induced GI injury. All patients were adults (median age: 64.5 y, range: 61 to 76 y) and there was gender parity. Patients receiving treatment for malignancies colorectum (n=5), breast (n=1),...
Define if the presence of morphologic features adenocarcinoma (ACA) in non-small cell lung carcinoma (NSCLC) on cytology specimens correlates with clinical and biologic features.A total 209 cases NSCLC diagnosed fine-needle aspiration a 3-year period were included.After review, classified as ACA (n = 115), favor 43), NSCLC-not otherwise specified (NOS) 18). Squamous (SCC) 14) SCC 19) excluded from further analysis. Patients EGFR-mutated tumors had longer overall survival than those EGFR...
Abstract Objectives Adenocarcinomas of the biliary tract frequently present diagnostic challenges because their histologic overlap with benign and preinvasive lesions. The molecular profiles adenocarcinomas vary by anatomical location. Variations in IDH1/2, common intrahepatic cholangiocarcinoma, can lead to defective production 5-hydroxymethylcytosine (5-hmC). Limited ancillary studies are available for adenocarcinomas, loss 5-hmC staining could serve as a helpful tool malignancies. Methods...
Abstract Objectives Neisseria gonorrhoeae infection of the anorectal tract is often asymptomatic and infrequently biopsied, but pathologists can be tasked with identifying histologic features possible infection. The study was undertaken to better characterize clinical morphologic confirmed gonococcal Methods From 2011 2020, 201 positive nucleic acid amplification testing samples from 174 patients collected distal colorectum and/or anus were matched eight concurrent biopsy specimens...
. Pancreatoblastoma is a rare malignant epithelial neoplasm of the pancreas, which often shows multiple lines differentiation, but defined by neoplastic cells with acinar differentiation and characteristic squamoid nests. Pediatric patients are most commonly affected, although subset known to occur in adults, diagnosis rarely considered elderly adults.
Gastric mucosal biopsies and resections from patients treated with neoadjuvant radiation and/or chemotherapy are frequently encountered. These samples may show histologic features related to therapy including inflammation, ulceration, epithelial atypia. In some cases, atypia be marked, prompting the use of adjunct p53 immunohistochemistry. We examined expression by immunohistochemistry in gastric mucosa following therapy.We evaluated histology immunohistochemical 57 3 biopsies, 60 for...