A5060309452- Proteoglycans and glycosaminoglycans research
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Bone Tissue Engineering Materials
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Exercise and Physiological Responses
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Magnesium Alloys: Properties and Applications
- COVID-19 and Mental Health
- Curcumin's Biomedical Applications
- Synthesis and biological activity
- Uterine Myomas and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- Quinazolinone synthesis and applications
- Healthcare and Venom Research
- Brucella: diagnosis, epidemiology, treatment
- Urinary Tract Infections Management
Cairo University
2020-2025
RWTH Aachen University
2024-2025
University Hospital Cologne
2023-2025
University Hospital Münster
2020-2024
Klinik für Frauenheilkunde
2022-2023
RMIT University
2016
ABSTRACT Biliary duct reconstruction is one of the most challenging parts liver transplantation and accounts for 40%–60% complications. While current stent‐based devices on market show promising results in reducing complications, they are manufactured from permanent synthetic materials require a second reintervention their removal. This exposes patients to other potential complications increases healthcare costs. study develops fabrication technique produce bioabsorbable biliary stent based...
Cancer has become the second cause of death worldwide after cardiovascular diseases. Thus, development efficient therapeutic approaches for cancer treatment seems necessary. One promising is depending on nanotechnology in terms drug delivery systems. ZnO nanoparticles have been approved their efficiency as a system due to unique properties. Metformin (1, 1-dimethylbiguanide hydrochloride) widely used an anti-diabetic drug. However, recent studies explored its repurposing anti-cancer The...
Recent approaches in breast cancer treatment involve exploring natural extracts either as substitutes for traditional chemotherapeutic agents or adjuvants to enhance their effectiveness. In this context, ethanolic from Withania Somnifera (WS) and Arctium Lappa (AL) have gained attention potential anticancer properties across various types. This study aimed investigate the vitro efficacy of both WS AL MCF7 cell line. The encompassed assessments total antioxidant activity, flavonoids, phenolic...
Abstract In several carcinomas, the SET Domain Containing 3, Actin Histidine Methyltransferase (SETD3) is associated with oncogenesis. However, there little knowledge about role of SETD3 in progression and prognosis breast cancer. this study, we first analyzed prognostic value cancer patients using database public Kaplan-Meier plotter. Moreover, vitro assays were performed to assess viability capacity invasion human cell lines. We observed that high expression was better relapse-free...
<title>Abstract</title> Aging is characterized by a decline in physiological functions and an increased susceptibility to age-related diseases. This study investigates the therapeutic potential of mesenchymal stem cells (MSCs) pyrroloquinoline quinone (PQQ), individually combination, counteract aging-related declines, with specific focus on their modulation AMP-activated protein kinase (AMPK) pathway, key regulator cellular energy homeostasis stress response. was induced thirty-seven female...
Injectable hydrogels with self-healing properties, tissue adhesion, biocompatibility, and cancer therapeutic capabilities offer a promising solution for addressing bone loss residual tumor cells following surgical resection of osteosarcoma. In this study, injectable adhesive hybrid were developed using natural silk-derived proteins, silk fibroin (SF), sericin (SS). The was surface functionalized dopamine (DOPA) forming SSDOPA, while the enzymatically oxidized (forming SFO) to introduce...
Triple-negative breast cancer (TNBC) is characterized by increased angiogenesis, metastasis, and poor survival. Dysregulation of the cell surface heparan sulfate proteoglycan signaling co-receptor Syndecan-1 linked to prognosis. To study its role in we silenced TNBC lines using a 3D human umbilical vein endothelial (HUVEC) co-culture system. siRNA depletion SUM-149, MDA-MB-468, MDA-MB-231 cells decreased HUVEC tubule network formation. Angiogenesis array revealed reduced VEGF-A tissue factor...
Syndecan-1 (Sdc-1) upregulation is associated with poor prognosis in breast cancer. Sdc-1 knockdown results reduced angiogenesis and the dysregulation of tissue factor (TF) pathway constituents. Here, we evaluate regulatory mechanisms functional consequences Sdc-1/TF-axis using overexpression approaches MCF-7 MDA-MB-231 cancer cells. Gene expression was analyzed by means qPCR. Thrombin generation cell migration were detected. Cell-cycle progression apoptosis investigated flow cytometry. In...
Syndecans are transmembrane heparan sulfate proteoglycans that integrate signaling at the cell surface. By interacting with cytokines, receptors, proteases, and extracellular matrix proteins, syndecans regulate proliferation, metastasis, angiogenesis, inflammation. We analyzed public gene expression datasets to evaluate dysregulation potential prognostic impact of Syndecan-3 in ovarian cancer. Moreover, we performed functional vitro analysis syndecan-3-siRNA-treated SKOV3 CAOV3 cancer cells....
Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a...
Glycosaminoglycans (GAGs) and proteoglycans (PGs) are major components of the glycocalyx. The secreted GAG CD44 ligand hyaluronic acid (HA), cell surface PG syndecan-1 (Sdc-1) modulate expression activity cytokines, chemokines, growth factors, adhesion molecules, acting as critical regulators tumor behavior. Here, we studied effect Sdc-1 siRNA depletion HA treatment on hallmark processes cancer in breast lines different levels aggressiveness. We analyzed synthesis, parameters relevant to...
We reported herein the synthesis of novel arylazo derivatives 3a-e incorporating isoquinoline moiety.A coupling reaction 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile 1 with diazotized heterocyclic amines 2 in ethanol presence sodium acetate to give 3a-e.Cytotoxic effect five on breast carcinoma MCF7 and hepatocellular HepG2 was carried out, followed by molecular functional-based assays, estimate anticancer these compounds. The fibroblast growth factor receptor (FGFR) epithelial...
Abstract Introduction Adenomyosis is a special subtype of endometriosis, affecting the myometrium, about 20% women in reproductive age period. Clinical symptoms and intensity are diverse can vary from heavy menstrual bleeding dysmenorrhea to infertility repeated pregnancy losses. Thus, patients often present with long history illness pending presumptive clinical or surgical diagnosis. A definitive diagnosis adenomyosis made upon histopathological examination verifying ectopic endometrial...
To the Editor, Medication-related problems have been estimated to cost Australian healthcare system approximately $660 million annually.1 In an attempt minimise medication errors, Commission on Safety and Quality in Health Care recommends use of a management plan (MMP). A MMP is designed for multidisciplinary hospital includes three key sections – list, risk assessment ‘issues’ sections.2 The was introduced at Northern Hospital (TNH) Melbourne, July–August, 2013. While reconciliation process...