A5065508113- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Marine Biology and Environmental Chemistry
- Developmental Biology and Gene Regulation
- Protist diversity and phylogeny
California Institute of Technology
2006-2008
Los Alamos National Laboratory
2008
Health First
2006
University of South Florida
2005
Abstract Notch signaling activates T lineage differentiation from hemopoietic progenitors, but relatively few regulators that initiate this program have been identified, e.g., GATA3 and cell factor-1 (TCF-1) (gene name Tcf7). To identify additional of specification, a cDNA library mouse Pro-T cells was screened for genes are specifically up-regulated in intrathymic precursors as compared with myeloid progenitors. Over 90 interest were 35 44 tested confirmed to be more highly expressed...
Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis gene expression trajectories from beginning to end specification, tests short-term Notch dependence these changes, and analyses effects overexpression two essential factors, namely PU.1 GATA-3....
The SpFoxB gene is transiently expressed first in the mesoderm, then endoderm and oral ectoderm during sea urchin gastrulation. Perturbations of a number proteins involved endomesoderm specification have been shown to alter mRNA levels SpFoxB, but cis-regulatory elements required for expression not examined. In order investigate this, we screened sequences that can drive its expression. Both positive negative were found be present. An enhancer was contains four GATA sites YY1 clustered...