A5022610868- Biochemical effects in animals
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Fungal Biology and Applications
- Proteoglycans and glycosaminoglycans research
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Nanoplatforms for cancer theranostics
- Neuroendocrine regulation and behavior
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Medicinal Plants and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Biochemical Analysis and Sensing Techniques
- Terahertz technology and applications
- Food Quality and Safety Studies
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Neurological Disorders and Treatments
- Glycosylation and Glycoproteins Research
Russian Academy of Sciences
2012-2025
Siberian Branch of the Russian Academy of Sciences
2014-2025
Institute of Cytology and Genetics
2015-2025
Siberian State Medical University
2016
Magnetic Fe3O4 nanoparticles (MNPs) are often used to design agents enhancing contrast in magnetic resonance imaging (MRI) that can be considered as one of the efficient methods for cancer diagnostics. At present, increasing specificity MRI agent accumulation tumor tissues remains an open question and attracts attention a wide range researchers. One modern efficiency is use molecules acidic microenvironment targeting, example, pH-low insertion peptide (pHLIP). We designed novel organosilicon...
This review considers glioma molecular markers in brain tissues and body fluids, shows the pathways of their formation, describes traditional methods analysis. The most important optical properties terahertz (THz) frequency range are also presented. New metamaterial-based technologies for marker detection at THz frequencies discussed. A variety machine learning methods, which allow sensitivity differentiation healthy tumor to be improved with aid tools, considered. actual results on...
Liver fluke causes severe liver damage in an infected human. However, the infection often remains neglected due to lack of pathognomonic signs. Nanoparticle-enhanced magnetic resonance imaging (MRI) offers a promising technique for detecting lesions induced by parasites.Surface modification iron oxide nanoparticles produced coprecipitation from solution Fe3+ and Fe2+ salts using 3-aminopropylsilane (APS) was carried out. The APS-modified were characterized transmission electron microscopy,...
The concepts of allostatic load and overload, i.e. a dramatic increase in the that predisposes to disease, have been extensively described literature. Here, we show rats engaging active offensive response (AOR) behavioral strategies chronic predator scent stress (PSS) display less anxiety behavior lower plasma cortisol levels versus passive defensive (PDR) PSS. In same PSS paradigm, AOR also higher lactate glutamate amygdala but not control-region hippocampus PDR rats. implications these...
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis therapy monitoring responses. Herein, albumin-AuNP agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or boron-neutron capture drug undecahydro-closo-dodecaborate (B12H12) bimodal human serum albumin (HSA) followed reacting the conjugates with AuNPs. In vitro...
New Findings What is the central question of this study? Stress‐sensitive arterial hypertension considered to be controlled by changes in and peripheral sympathetic regulating mechanisms, which eventually result haemodynamic alterations blood pressure elevation. Therefore, study early stages development particular interest, because it helps understanding aetiology disease. main finding its importance? Non‐invasive vivo investigation ISIAH rats demonstrated that establishment sustainable...
Hemozoin is the pigment produced by some blood-feeding parasites. It demonstrates high diagnostic and therapeutic potential. In this work formation of co-called hemozoin "knobs" – bile duct ectasia filled up - in Opisthorhis felineus infected hamster liver has been observed. The O. was examined histological analysis magnetic resonance imaging (MRI). identified Fourier transform infrared spectroscopy resolution electrospray ionization mass spectrometry analysis. crystals were characterised...
Variations in anxiety-related behavior are associated with individual allostatic set-points chronically stressed rats. Actively offensive rats the externalizing indicators of sniffling and climbing stimulus material tearing during 10 days predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, adrenal 11-dehydrocorticosterone content compared to passively defensive internalizing freezing grooming, as well controls without any behavioral changes....
Adjuvant chemotherapy with temozolomide (TMZ) is an intrinsic part of glioblastoma multiforme (GBM) therapy targeted to eliminate residual GBM cells. Despite the intensive treatment, a relapse develops in majority cases resulting poor outcome disease. Here, we investigated off-target negative effects systemic on glycosylated components brain extracellular matrix (ECM) and their functional significance. Using elaborated animal model, demonstrated that healthy tissue resists cell proliferation...
Glioblastoma (GB) is an aggressive cancer with a high probability of recurrence, despite active chemoradiotherapy temozolomide (TMZ) and dexamethasone (DXM). These systemic drugs affect the glycosylated components brain tissue involved in GB development; however, their effects on heparan sulfate (HS) remain unknown. Here, we used animal model relapse which SCID mice first received TMZ and/or DXM (simulating postoperative treatment) subsequent inoculation U87 human cells. Control, peritumor...
The method of Fe3O4 magnetic nanoparticle synthesis by co-precipitation, modification 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. characterization nanoparticles scanning electron microscopy, transmission Fourier-transform infrared spectroscopy, elemental thermogravimetric analyses as well dynamic light scattering z-potential measurements provided. effect on the viability mouse human peripheral blood mononuclear cells tested flow cytometry....
Background The medications produced from natural products are widely used as prophylactics for sickness induced by alcohol consumption. One such prophylactic is the Reishi mushroom, Ganoderma lucidum . Because of antioxidant properties these preparations, we expect neuroprotective effects Reishi‐based in alcohol‐treated animals. Methods (R) suspension was water extract Altaian mushrooms. Sprague–Dawley male rats were separated into following 3 experimental groups: Group A + R received (6...
A paradoxical reduction in anxiety levels chronic predator stress paradigm (PS) Sprague-Dawley rats has recently been shown previous works. In this paper, we studied the possible neurobiological mechanism of phenomenon. We segregated PS-exposed into high- and low-anxiety phenotypes. The long-lasting effects PS on corticosterone levels, blood flow speed carotid arteries, diffusion coefficient, 1H nuclear magnetic resonance spectra hippocampus were compared high-anxiety rats. addition,...
In this research, an experimental U87 glioblastoma small animal model was studied. The association between stages and the spectral patterns of mouse blood serum measured in terahertz range analyzed by time-domain spectroscopy (THz-TDS) machine learning. THz spectra preprocessing included (i) smoothing using Savitsky–Golay filter, (ii) outlier removing isolation forest (IF), (iii) Z-score normalization. sequential informative feature-selection approach developed a combination principal...
European liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, severe cases, malignant transformation of bile ducts. Due absence specific symptoms, frequently neglected for a long period. The association with almost incurable duct cancer rising international migration people that increases risk...
The aim of the present study was to examine how administration a compound 1,3,4- thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine, hydrobromide (L-17) with hypothermia inducing properties affects brain metabolism. mechanism by which L-17 induces is unknown; it may involve hypothalamic central thermoregulation as well act via inhibition energy We tested hypothesis that induce directly inhibiting in vivo carried out on Sprague-Dawley adult rats. Two doses were administered (190...