A5001764406- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Renal Diseases and Glomerulopathies
- Pediatric health and respiratory diseases
- Dermatological and COVID-19 studies
- Cytomegalovirus and herpesvirus research
- Microtubule and mitosis dynamics
- Exercise and Physiological Responses
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Synthesis and Biological Evaluation
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Lysosomal Storage Disorders Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemoglobinopathies and Related Disorders
Necmettin Erbakan University
2014-2025
Erciyes University
2024
Purpose: This study aimed to evaluate the possible anticancer and apoptotic effect of carnosol carnosic acid on non-small cell lung cancer (NSCLC) lines in vitro.
 Materials Methods: Three different NSCLC (H441, H520, H661) were used treatment (carnosol treatment) control (no groups established all lines. The IC50 doses determined by MTT method changes expression levels apoptosis-related genes (Bax, Bak, caspase-3, p53, c-Myc, Bcl-2, Bcl-XL) demonstrated real-time polymerase chain...
Background Obstructive sleep apnea (OSA) is a common disorder, frequently observed in obese individuals, with shared mechanisms involving leptin and its receptor, which regulate appetite energy expenditure. SH2B1 key enhancer of signaling the receptor pathway. This study aimed to investigate association between variants OSA.
B cell maturation antigen (BCMA) is a TNF superfamily protein expressed predominantly on plasmablasts and plasma cells. BCMA, along with TACI BAFF-R, has been implicated for proper maturation, differentiation, survival. Patients variants in BAFF-R have common variable immunodeficiency (CVID), but the impact of BCMA human disease not yet reported. Here, we describe three patients from two consanguineous families who presented early onset recurrent upper lower respiratory tract infections....
SUMMARY OBJECTIVE: The purpose of this study was to assess the association between clinical, laboratory, and functional analyses polymorphism in FCGR3A gene individuals with NK cell deficiency. METHODS: A total 15 deficiency patients 10 age-matched healthy controls underwent subgroup, cytotoxicity, whole-exome analysis next-generation sequencing. RESULTS: Three different subsets (CD56brightCD16neg, CD56brightCD16int, CD56dimCD16hi) were identified. No statistically significant difference...
The study aimed to investigate the expression profiles of transcription factors, cytokines, and co‐stimulatory molecules in helper T (Th)‐cell subsets within bronchoalveolar lavage (BAL) samples patients with interstitial lung diseases (ILDs). Twenty ILDs were included study, comprising those idiopathic pulmonary fibrosis (IPF) (n:8), autoimmune‐related (auto‐ILD) (n:4), orphan (O‐ILD) alongside five control subjects. Flow cytometry was employed evaluate Th cytotoxic cell (CTL) ratio BAL...
In this study, we aimed to report long-term follow-up of our pediatric and adult patients with DCLRE1C (DNA cross-link repair 1C) hypomorphic mutation who were diagnosed leaky severe combined immunodeficiency (SCID).
CD19 deficiency is a rare, predominantly antibody deficiency, and there are few studies showing that it can be seen in autoimmune diseases. The aim of study was evaluated to transcription factor cytokine expressions helper T (Th)‐cell subsets the possible mechanism role this expression disease. Transcription Th1, Th2, Th17, regulatory (Treg) cells were investigated by real‐time polymerase chain reaction (qPCR) method. In study, patient/control comparison, Th1 (T‐bet, STAT1, STAT4) found...
Coronavirus 2019 disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread to more than 200 countries worldwide. We aimed present pancreatitis (AP) cases SARS-CoV-2 viral infection.The study was conducted retrospectively between April 2020 and June in Necmettin Erbakan University Meram, Medical Faculty Hospital, 150 hospitalized patients diagnosed with COVID-19 were included. The degree of determined according Atlanta classification. Organ...
Severe combined immunodeficiency (SCID) is an inborn errors of immunity (IEI) disorder characterized by impairment in the development and function lymphocytes could be fatal if not treated with hematopoietic stem cell transplant first 2 years life. There are various diagnostic criteria for SCID among different primary societies. We retrospectively evaluated clinical laboratory findings 59 patients followed up diagnosis at our clinic over past 20 order to develop algorithm that would help...
Amaç: DCLRE1C genindeki mutasyonlar Artemis proteininin fonksiyonel olarak bozulmasına neden olur ve T/B hücre gelişimi olumsuz etkilenir. Bu mutasyonun bir sonucu olarak, genellikle ağır kombine immün yetmezlik (CID) kliniği ortaya çıkar. Akraba evliliğinin yaygın olduğu bölgemizde bu mutasyona bağlı CID vakalarına sıklıkla rastlanmaktadır. nedenle şüpheli hastalar ilgili gen mutasyonu açısından vakit kaybetmeden değerlendirilmelidir. Mutasyonların tespitinde daha karmaşık maliyetli...
ÖZET Amaç: Bu çalışmada obstrüktif uyku apnesi sendromu (OSAS)'na bağlı obezitenin ortaya çıkışında hipotalamik beslenmeyi düzenleyici nöropeptitler olan Nöropeptid Y (NPY), Orexin, pro-opiomelanokortin (POMC) ve leptin seviyeleri ile PAP tedavisi gözlenen kilo değişimi arasında bir ilişki olup olmadığının araştırılması amaçlandı. Gereç Yöntem: Çalışmaya Göğüs Hastalıkları laboratuvarında OSAS tanısı alan planlanan 18-65 yaş arası 38 gönüllü erkek hasta dahil edildi. Hastalarda aldıktan...
Objective: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for Disease 2019 (COVID-19), elicits a strong immune response similar to that seen in other viral infections.The predominant cell type this also influences disease prognosis.This study, conducted between 2022 and May 2023, aimed evaluate transcription factors cytokine expressions of Th (helper T) subsets at time diagnosis after discharge patients with nonsevere COVID-19.Materials Methods:...
The objective of research was to examine the likely anticancer effectiveness distinct pillar[5] arene derivatives, ws-penta-P[5] and ws-deca-P[5], on breast lung cancer cell lines in vitro. To achieve this goal, (MCF7) cells, (A549) healthy cells (HEK293) were utilized. IC50 dose ws-deca-P[5] determined using MTT method. Both treatment (pillar[5] applied) control not groups established for all three lines. Real-time polymerase chain reaction (qPCR) used evaluate changes gene expression...
Objective In this study, we explored the expression of transcription factors, cytokines, and co-stimulatory molecules within helper T (Th) cell subsets (Th1, Th2, Th17 Treg) patients with hypomorphic DCLRE1C gene mutations.
Introduction and aim. Mutation(s) in the gene encoding CD19 molecule affect protein expression primary immunodeficiency (PID) occurs. The PCR-RFLP method, which is faster cheaper than other mutation detection methods, rarely used diagnosis of PID. study aimed to genetically identify deficiency, a PID, using method. Material methods. A total 8 patients two healthy controls were included relevant region genotypes determined by performing analysis. Results. index case, newborn baby mother also...