A5013977804- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Lysosomal Storage Disorders Research
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Health and Disease Prevention
- Organ Donation and Transplantation
- Autoimmune Bullous Skin Diseases
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Biomarkers in Disease Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
Necmettin Erbakan University
2015-2024
Wroclaw Medical University
2023
Turkish Society of Hematology
2023
ENT and Allergy
2021
Erzincan Binali Yıldırım University
2012-2017
Konya Food and Agriculture University
2013-2015
Selçuk University
2009-2014
Creative Research Enterprises (United States)
2014
Iğdır Üniversitesi
2014
Charles R. Drew University of Medicine and Science
2012
Abstract Neutrophil‐to‐lymphocyte ratio ( NLR ) was introduced as a potential marker to determine inflammation in end‐stage renal disease ESRD patients. Recently, platelet‐to‐lymphocyte PLR and were found positively correlated with inflammatory markers including tumor necrosis factor‐α TNF ‐α) interleukin IL )‐6 cardiac noncardiac Data regarding its association are lacking hemodialysis HD peritoneal dialysis PD Hence, we aimed the relationship between , This cross‐sectional study involving...
Abstract Background Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand one of the established potential risk factors for severe coronavirus 2019 (COVID-19). Case morbidity mortality rates any type infection have always been much higher CKD, haemodialysis (HD) RT patients than general population. A large study comparing COVID-19 outcome moderate to advanced CKD (Stages 3–5), HD with a control group is still lacking. Methods We conducted...
Patients with end-stage renal disease (ESRD) have elevated serum levels of inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6. Systemic inflammation was found to be correlated coronary artery (CAD) in this population. Neutrophil-to-lymphocyte ratio (NLR) introduced as a potential marker determine cardiac non-cardiac disorders. Data regarding NLR its association are lacking. We aimed the relationship between ESRD patients.This...
Inflammation contributes to the pathogenesis of acute kidney injury (AKI). IL-33 is a proinflammatory cytokine, but its role in AKI unknown. Here we observed increased protein expression full-length following induction with cisplatin. To determine whether promotes injury, administered soluble ST2 (sST2), fusion that neutralizes activity by acting as decoy receptor. Compared cisplatin-induced untreated mice, mice treated sST2 had fewer CD4 T cells infiltrate kidney, lower serum creatinine,...
ABSTRACT The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are entities without immune complex deposits which can cause podocyte injury, thus frequently grouped under the umbrella of podocytopathies. Whether MCD FSGS may represent a spectrum same remains matter conjecture. Both require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases response rates...
Coronavirus Disease 19 (COVID-19) vaccine platforms are becoming available and the most promising strategy to curb spread of SARS-CoV-2 infections. However, numerous uncertainties exist regarding pros cons vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members Immunonephrology Working Group (IWG) European Renal Association-European Dialysis Transplant Association (ERA-EDTA) discuss thirteen frequently-asked questions safety...
ABSTRACT Patients with immune-mediated kidney diseases are at increased risk of severe coronavirus disease 2019 (COVID-19). The international rollout COVID-19 vaccines has provided varying degrees protection and enabled the understanding vaccine efficacy safety. immune response to is lower in most patients diseases; either related immunosuppression or comorbidities complications caused by underlying disease. Humoral response, measured presence antibodies, impaired absent receiving rituximab,...
ABSTRACT Updated guidelines on the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) were released in 2021 by American College Rheumatology jointly with Vasculitis Foundation and, subsequently, 2022 European Alliance Associations for Rheumatology. In addition, 2021, Kidney Disease: Improving Global Outcomes had updated recommendations treatment AAV glomerulonephritis (AAV-GN). involvement is particularly relevant microscopic polyangiitis and granulomatosis...
Abstract Health‐related quality of life ( HRQoL ) and sleep SQ were impaired in patients with end‐stage renal disease ESRD ). The impairment both being a depressive mood found to be associated increased morbidity mortality dialysis patients. We aimed investigate the association between , depression, define independent predictors depression peritoneal PD hemodialysis HD Ninety (41 females, 49 males mean age 50 ± 15.7 years) 64 (27 37 52.4 15.3 receiving replacement therapy for at least 3...
Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and also found to be ongoing renal transplant (Rtx) patients. As a sign atherosclerosis, carotid intima–media thickness (CIMT) has been widely accepted as strong predictor cardiovascular (CVD) mortality end-stage (ESRD) Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), neutrophil-to-lymphocyte ratio (NLR) were introduced oxidative stress inflammatory biomarkers ESRD. The role Rtx terms...
Summary Background and objectives Malnutrition, inflammation, atherosclerosis/calcification (MIAC) endothelial dysfunction are the most commonly encountered risk factors in pathogenesis of cardiovascular disease ESRD patients. Epicardial adipose tissue (EAT) is true visceral fat depot heart. The relationship between CAD EAT was shown patients with high coronary artery disease. In this study, we aimed to investigate MIAC syndrome Design, setting, participants, & measurements Eighty 27...
Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Contrast-induced nephropathy (CIN) most important CA-related complication. Oxidative stress plays a significant role in its pathophysiology. Lycopene (LPN) natural substance with strong antioxidant capacity. The present study aimed to investigate potential preventive effects LPN against CIN. In total, 28 male Wistar albino rats were divided into 4 groups 7 each group;...
Chronic inflammation was found to be correlated with coronary (CAC) and thoracic peri-aortic calcification (TAC) in end-stage renal disease (ESRD) patients. Neutrophil-to-lymphocyte ratio (NLR) introduced as a potential marker determine cardiac noncardiac disorders. Data regarding NLR its association TAC CAC are lacking. We aimed the relationship between vascular ESRD This cross-sectional study involving 56 patients (22 females, 34 males; mean age, 49.9 ± 14.2 years) receiving peritoneal...
Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) contrast-induced nephropathy (CIN). Patients with DKD were found be more prone CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in CIN unknown.Thirty male Sprague-Dawley rats enrolled. The first group was comprised healthy (HRs), whereas other four groups made up (DRs), (CIN + DRs), melatonin-treated (MTDRs), DRs (MTCIN DRs). All except HRs received 50 mg/kg/day...
Fabry disease is characterised by neuropathic pain and accelerated vascular disease. This study evaluates the utility of corneal confocal microscopy (CCM) to non-invasively quantify nerve endothelial cell morphology dendritic (DC) density in relation severity subjects with Seventeen consecutive participants 17 healthy control were included this cross-sectional study. was measured using Mainz Severity Score Index (MSSI). Central sensitivity assessed a contact esthesiometer. There significant...
Objective: Both the incidence and prevalence of end-stage renal disease (ESRD) in elderly patients are increasing worldwide. Elderly ESRD have been found to be more prone depression than general population. There many studies that addressed relationship between sleep quality (SQ), depression, health related life (HRQoL) patients, but previous not confirmed association hemodialysis (HD) patients. Therefore, aim present study was demonstrate this HD Patients methods: Sixty-three (32 females 31...
<b><i>Background/Aims: </i></b>Fabry disease is a treatable cause of chronic kidney (CKD) characterized by genetic deficiency α-galactosidase A. European Renal Best Practice (ERBP) recommends screening for Fabry in CKD patients. However, this based on expert opinion and there are no reports the prevalence stage 1-5 CKD. Hence, we investigated patients not receiving renal replacement therapy. <b><i>Methods: </i></b>This prospective study...
Acute kidney injury (AKI) is an independent risk factor for morbidity and mortality. This review provides essential information the diagnosis management of AKI. Blood urea nitrogen serum creatinine are used The also focuses on recent studies AKI using RIFLE (R-renal risk, I-injury, F-failure, L-loss function, E-end stage disease) Kidney Injury Network criteria, urine biomarkers. Dialysis only Food Drug Administration-approved therapy Recent dose dialysis in reviewed.
Prolonged cold ischemia (CI) is a risk factor for the development of delayed graft function that predicts reduced 5-year kidney transplant survival. CI results in caspase-3 activation, tubular injury, and apoptosis. Autophagy, highly conserved pathway permits recycling nutrients within cell during stress, linked to We hypothesized preservation would induce autophagy. sought determine apoptosis autophagic flux CI.Autophagic were examined kidneys wild-type green fluorescent protein...