A5083423809- Spaceflight effects on biology
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Muscle Physiology and Disorders
- Space Exploration and Technology
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Muscle metabolism and nutrition
- Maternal and fetal healthcare
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Maternal and Perinatal Health Interventions
- Organ Transplantation Techniques and Outcomes
- Healthcare Policy and Management
- Protein Degradation and Inhibitors
- PARP inhibition in cancer therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Ubiquitin and proteasome pathways
- Advanced Sensor and Energy Harvesting Materials
- Congenital heart defects research
- Genetic Associations and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Infection Control and Ventilation
- Cardiac Fibrosis and Remodeling
SouthCoast Health
2020-2024
Brown University
2013-2024
Marshall University
2021
The Ohio State University Wexner Medical Center
2014-2020
The Ohio State University
2014-2020
Stanford University
2013-2014
Tufts University
2008-2013
St. Elizabeth's Medical Center
2008-2013
Miriam Hospital
2013
Stanford Medicine
2012
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) study cell-level function and gene expression. The hiPSC-CMs were cultured ISS for 5.5 weeks their expression, structure, functions compared with ground control hiPSC-CMs. Exposure caused alterations in hiPSC-CM calcium handling. RNA-sequencing...
With current plans for manned missions to Mars and beyond, the need better understand, prevent, counteract harmful effects of long-duration spaceflight on body is becoming increasingly important. In this study, an automated heart-on-a-chip platform was flown International Space Station a 1-mo mission during which contractile cardiac function monitored in real-time. Upon return Earth, engineered human heart tissues (EHTs) were further analyzed with ultrastructural imaging RNA sequencing...
In 2005, the lung allocation score (LAS) was implemented to prioritize organ minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older sicker patients without changing Its effect on resource use is unknown.To determine changes over time transplant admissions.Solid recipients were identified within Nationwide Inpatient Sample (NIS) data from 2000 2011. Joinpoint regression methodology performed identify a point change mean total hospital charges...
Abstract While the effects of microgravity on inducing skeletal muscle atrophy have been extensively studied, impacts myogenesis and its mechanisms remain unclear. In this study, we developed a microphysiological system engineered tissue (EMT) fabricated using collagen / Matrigel composite hydrogel murine myoblasts. This 3D EMT model allows non-invasive quantitative assessment contractile function. After applying 7-day differentiation protocol to induce myotube formation, EMTs clearly...
Skeletal muscle atrophy has been well characterized in various animal models, and while certain pathways that lead to disuse its associated functional deficits have studied, available drugs counteract these deficiencies are limited. An ex vivo tissue-engineered skeletal offers a unique opportunity study physiology controlled vitro setting. Primary mouse myoblasts isolated from adult were tissue engineered into bioartificial muscles (BAMs) containing hundreds of aligned postmitotic fibers...
Poly(dimethylsiloxane) (PDMS) is a commonly used polymer in organ-on-a-chip devices and microphysiological systems. However, due to its hydrophobicity permeability, it absorbs drug compounds, preventing accurate screening applications. Here, we developed an effective facile method prevent the absorption of drugs by utilizing PDMS–PEG block copolymer additive pretreatment. First, incorporated into PDMS address inherent hydrophobicity. Next, addressed permeability eliminating concentration...
Background: Proper wound healing is pivotal to successful surgical outcomes. Previous studies have shown that growth factors can be used enhance tissue repair under impaired conditions. However, because of limited delivery methods, the in these were delivered either topically or as a single local administration. Methods: Sixty Sprague-Dawley rats divided equally into five groups and served untreated normal controls implanted subcutaneously with novel sustained-release drug system through...
Objective To examine hospital resources associated with patient outcomes for aortic valve replacement (AVR), including inpatient adverse events and mortality. Study Design We used the Nationwide Inpatient Sample to identify AVR procedures from 1998 2010 American Hospital Association Annual Survey augment characteristics. Primary included mortality development of events, identified using standardized safety indicators (PSI). Patient characteristics PSI were evaluated univariate multivariate...
Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer’s disease (AD) are somewhat similar, it is common to misdiagnose these two conditions. Although there fluid markers detectable in humans with NPH AD, determining which biomarker optimal representing genetic characteristics consistent throughout species poorly understood. Here, we hypothesize that can be differentiated from AD mRNA biomarkers unvaried proximity telomeres. We examined human caudate nucleus tissue samples for the...
Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon can lead to cardiovascular diseases. Given previously reported multiple factors associated with high mutation rates, we sorted the relative mutability human genes by (i) proximity telomeres and/or (ii) adenine thymine (A+T) content. We extracted genomic information using genome data viewer examined 118 channel 143 GPCR based on their association (ii). then assessed these two 31 encoding or GPCRs that targeted...
Monogenic hypertension is rare and caused by genetic mutations, but whether factors associated with mutations are disease-specific remains uncertain. Given two high mutation rates, we tested how many previously known genes match (i) proximity to telomeres or (ii) adenine thymine content in cardiovascular diseases (CVDs) related vascular stiffening. We extracted genomic information using a genome data viewer. In human chromosomes, 64 of 79 loci involving >25 single nucleotide polymorphisms...
Thromboembolic and bleeding events are potential complications following left ventricular assist device implantation. A tight control of the international normalized ratio (INR) is believed to be crucial in reduction postimplant complications. There significant variability among institutions as whether a implanting centre should managing INR. In this study, we evaluated effect INR management strategies maintaining therapeutic INR.A retrospective review was utilized identify patients...
The glucagon-like peptide-1 receptor (GLP-1R) agonists reduce glycated hemoglobin in patients with type 2 diabetes. Mounting evidence indicates that the potential of GLP-1R agonists, mimicking a 30 amino acid ligand, GLP-1, extends to treatment neurodegenerative conditions, particular focus on Alzheimer's disease (AD). However, mechanism underlies regulation availability brain AD remains poorly understood. Here, using whole transcriptome RNA-Seq human postmortem caudate nucleus and chronic...