A5037840671- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Epigenetics and DNA Methylation
- Protease and Inhibitor Mechanisms
- Microtubule and mitosis dynamics
- Tea Polyphenols and Effects
- Amino Acid Enzymes and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Cardiac Fibrosis and Remodeling
- Skin and Cellular Biology Research
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Ginkgo biloba and Cashew Applications
- Antioxidant Activity and Oxidative Stress
- Chemotherapy-induced cardiotoxicity and mitigation
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Force Microscopy Techniques and Applications
- Wound Healing and Treatments
- Melanoma and MAPK Pathways
- Silk-based biomaterials and applications
University of Glasgow
2017-2023
Cancer Research UK Scotland Institute
2017-2022
Cancer Research UK
2022
Switch
2022
Alexander Fleming Biomedical Sciences Research Center
2014-2017
Article10 July 2017Open Access Source DataTransparent process Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium Steven E Reid Cancer Research UK Beatson Institute, Glasgow, Search for more papers by this author Emily J Kay Lisa Neilson Anne-Theres Henze Lab of Inflammation and Angiogenesis, Center Biology, VIB, Leuven, Belgium Jens Serneels Ewan McGhee Sandeep Dhayade Colin Nixon John BG Mackey Inflammation, Repair Development, Imperial College London,...
Abstract Background Cellular metabolism is an integral component of cellular adaptation to stress, playing a pivotal role in the resistance cancer cells various treatment modalities, including radiotherapy. In response radiotherapy, engage antioxidant and DNA repair mechanisms which mitigate remove damage, facilitating cell survival. Given reliance these on amino acid metabolism, we hypothesised that controlling exogenous availability non-essential acids serine glycine would radiosensitise...
Abstract Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine synthesis, most transformed rely on uptake to meet their increased biosynthetic requirements. Solute carriers (SLCs), family of transmembrane nutrient transport proteins, are the gatekeepers acquisition and exchange mammalian emerging as anticancer therapeutic targets; however, SLCs that mediate cancer remain unknown. Here we an arrayed RNAi screen SLC-encoding genes while monitoring consumption...
ABSTRACT Pancreatic cancer is a deadly and highly metastatic disease, although how lesions establish not fully understood. A key feature of pancreatic tumours extensive fibrosis deposition extracellular matrix (ECM). While cells are programmed by stimuli derived from stiff ECM, metastasis requires loss attachment adaptation to softer microenvironment at distant sites. Growing evidence suggests that ECM influences cell behaviour. Here, we argue this influence reversible can be reprogrammed...
Tissue regeneration and wound healing are severely impaired in diabetes associated with poor circulation dysfunctional blood vessels. Angiotensin II inhibitors anti-hypertensive drugs used clinical practice to regulate pressure could affect tissue remodeling. We hypothesize that blocking angiotensin II, using Losartan, facilitate diabetic mice. To this end, we established an experimental model of streptozotocin-induced Our data demonstrated Losartan accelerates repair normalizes stromal...
Breast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, B, Her2 over-expressing and basal-like (BL). These tumour sub-types require different treatments have risks progression. BL cancers considered sub-group Triple negative (TN) since they lack estrogen (ER), progesterone (PR) expression. No targeted treatment currently exists for TN/BL cancers. Thus it important to identify potential therapeutic targets describe their relationship...
The hypothesis that incorporation of epigallocatechin gallate (EGCG) into nanoemulsions may increase its bioactivity compared with EGCG aqueous solutions was examined in mice. After an vitro study a model system stimulated gastrointestinal conditions, the following were used mice experiment: Emulsion I: emulsion water oil (W/O), which contained 0.23 mg/mL phase; II: (O/W), 10% olive and esterified fatty III: O/W (W1/O/W2; 8:32:60), 32% phase. 2 h administration by gavage 0.1 mL...
The Arp2/3 complex is essential for the assembly of branched filamentous actin but its role in physiology and development surprisingly little understood. Melanoblasts deriving from neural crest migrate along developing embryo traverse dermis to reach epidermis colonising skin eventually homing within hair follicles. We have previously established that Rac1 Cdc42 direct melanoblast migration vivo. hypothesised might be main downstream effector these small GTPases. Arp3 depletion melanocyte...
Abstract Pancreatic cancer is a deadly disease with high rates of metastasis, though how tumor cells establish metastatic lesions not fully understood. A key feature primary pancreatic tumors extensive fibrosis due to deposition extracellular matrix. While are programmed by stimuli derived from stiff ECM, metastasis requires loss attachment as well adaptation softer microenvironment upon reaching distant sites. Growing evidence suggests that ECM influences cell behaviour. Here we argue this...