A5059237275- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- RNA modifications and cancer
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Cosmology and Gravitation Theories
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Enzyme Structure and Function
- Neutrino Physics Research
- Animal Disease Management and Epidemiology
- Toxic Organic Pollutants Impact
- Electrochemical sensors and biosensors
- Influenza Virus Research Studies
- Protein Structure and Dynamics
- RNA Research and Splicing
- Computational Physics and Python Applications
- Cancer therapeutics and mechanisms
- Effects and risks of endocrine disrupting chemicals
- Cytomegalovirus and herpesvirus research
Gansu Agricultural University
2024-2025
Liaoning University of Technology
2025
Jinan University
2021-2025
Institute of High Energy Physics
2015-2024
Chinese Academy of Sciences
2015-2024
Institute of High Energy Physics
2020-2024
A. Alikhanyan National Laboratory
2024
University of Antwerp
2024
Paul Scherrer Institute
2024
Michigan State University
2023
Abstract Novel oxygen sensors consisting of a [Ru(bpy) 2 phen] 2+ (bpy: 2,2′‐bipyridyl, phen: phenathroline) portion covalently grafted to mesostructured silica‐based network are prepared in situ via sol–gel approach with the help cetyltrimethylammoniumbromide (CTAB) surfactant. 1,10‐Phenanthroline 3‐(triethoxysilyl)propyl isocyanate is used as not only precursor but also second ligand Ru(bpy) Cl · 2H O complex prepare sol–gel‐derived silicates for an sensor. For comparison purposes, which...
The TREX complex (TREX) plays key roles in nuclear export of mRNAs. However, little is known about its transcriptome-wide binding targets. We used individual cross-linking and immunoprecipitation (iCLIP) to identify the sites ALYREF, an mRNA adaptor TREX, human cells. Consistent with previous vitro studies, ALYREF binds a region near 5' end CBP80-dependent manner. Unexpectedly, we identified PABPN1-dependent 3' mRNA. Furthermore, processing factor CstF64 directly interacts required for...
Abstract The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes vaccine composition. Recent H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human infections. Here, we report a V H 1-69 gene-encoded monoclonal antibody (mAb) designated H3v-47 exhibits potent cross-reactive neutralization activity and swine circulated since 1989. crystal structure electron microscopy reconstruction Fab with the...
Urban green development is crucial for citizen well-being and serves as a key pillar of sustainable strategies. Collaborative governance mechanisms help address management, technical, financial challenges in urban development. The renovation old residential communities within the context renewal becoming focal point Chinese cities. To promote China, this study introduces collaborative mechanism government–social capital cooperation identifies factors influencing social participation A hybrid...
Topoisomerases are critical for replication, DNA packing and repair, as well transcription by allowing changes in topology. Cellular is present both nuclei mitochondria, mitochondrial topoisomerase I (Top1mt) the only specific mitochondria vertebrates. Here, we report detail generation of TOP1mt knockout mice, demonstrate that (mtDNA) displays increased negative supercoiling cells murine tissues. This finding suggested imbalanced activity absence Top1mt other topoisomerases mitochondria....
mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that any type of PTC (UAA, UAG, UGA) detained in the nucleus whereas their wild-type counterparts rapidly exported. This retention is strictly reading-frame dependent. Strikingly, our data indicate translating ribosomes proofread frame and detect PTCs nucleus. Moreover, shuttling NMD protein Upf1 specifically associates with PTC+ required for nuclear...
Photoluminescence quenching of colloidal CdSe core/shell quantum dots (QDs) with CdS, ZnS and CdS/CdZnS/ZnS shells in the presence hole-transporting materials (HTMs) is studied by means steady-state time-resolved photoluminescence spectroscopy. Static surprisingly found to play an even more important role PL process than dynamic one originating from a hole transfer QDs HTMs. The static efficiency single CdS 3 6 monolayers much larger that multilayer shell. experimental results are for...
RNase J is a conserved ribonuclease that belongs to the β-CASP family of nucleases. It possesses both endo- and exo-ribonuclease activities, which play key role in pre-rRNA maturation mRNA decay. Here we report high-resolution crystal structures Deinococcus radiodurans complexed with RNA or uridine 5′-monophosphate presence manganese ions. Biochemical structural studies revealed uses zinc ions for two-metal-ion catalysis. One residue among orthologues (motif B) forms specific electrostatic...
The current treatment options for isolated iliac artery aneurysm (IIAA) are mainly endovascular (ET) and open surgery. ET carries risks such as endoleaks stent displacement, while elective surgical repair of IIAAs significant risk mortality. Therefore, this report presents a case laparoscopic surgery IIAA, providing new approach treating IIAA. Under guidance, the IIAA was resected, an artificial graft implanted to complete At 6 months follow-up, patient remained well, patent.
Planting halophytes is a widely used method of phytoremediation for saline soils. The succulent Halogeton glomeratus and Suaeda glauca are remediation soil in the arid region Northwestern China. However, whether intercropping H. S. can increase improvement effect yet to be proved. Therefore, this study analyzed three planting modes: monocropping (Hg), (Sg), (Hg||Sg). These were applied field experiments, with biomass physicochemical properties measured each treatment, mechanism was using...
Introduction Inorganic phosphorus (Pi) is an indispensable nutrient for plant growth, with phosphate transporter proteins (PHTs) having key roles in Pi uptake, transport, and signal transduction plants. However, a systematic comprehensive genomic analysis of the wheat PHT family (covering PHT1-5 PHO1 ) lacking. Methods In view this, we successfully identified 180 Triticum aestivum ( TaPHT members 6 families using bioinformatics, performed in-depth phylogenetic analyses between these protein...
A diverse superfamily of phospholipases consisting the type VI lipase effectors Tle1–Tle5 secreted by bacterial secretion system (T6SS) have recently been identified as antibacterial that hydrolyze membrane phospholipids. These show no significant homology to known lipases, and their mechanism targeting hydrolysis phospholipids remains unknown. Here, crystal structure Tle1 (∼96.5 kDa) from Pseudomonas aeruginosa refined 2.0 Å resolution is reported, representing first this superfamily. Its...
Antimicrobial peptides (AMPs) show high antibacterial activity against pathogens, which makes them potential new therapeutics to prevent and cure diseases. Porcine beta defensin 2 (pBD2) is a newly discovered AMP has shown different bacterial species including multi-resistant bacteria. In this study, the functional mechanism of pBD2 Staphylococcus aureus was investigated. After S. cells were incubated with concentrations pBD2, morphological changes in locations detected by electron...
Common wheat production is significantly influenced by abiotic stresses. Identifying the genetic loci for seedling root traits and developing available molecular markers are crucial breeding high yielding stable varieties. In this study, five traits, including length (RL), surface area (RA), volume (RV), number of tips (RT), dry weight (RW), were measured in Wp-072/Wp-119 recombinant inbred line (RIL) population. Genotyping was conducted RIL population their parents using 90K...
In this study, a novel multifunctional glycoside hydrolase (GH) with two distinct domains homologous to the GH family 5 (GH5) and 26 (GH26) was isolated from rumen microorganism Segatella bryantii. The heterologous expression product of enzyme exhibited both endo-β-1,4-glucanase endo-β-1,4-mannanase activities. Intriguingly, segmental studies indicated that GH26 domain alone contributed β-mannanase activity, its specific activity reached 2060 U/mg under optimal conditions (30 °C, pH 5.5)....
Abstract White spot syndrome virus (WSSV), Taura (TSV) and infectious hypodermal haematopoietic necrosis (IHHNV) have been responsible for major pandemics affecting the shrimp farming industry. Shrimp samples were collected from eight farms in Hainan Province, China, during 2007 analysed by polymerase chain reaction (PCR) or reverse transcriptase PCR methods to determine prevalence of these viruses. From sampling locations, only one farm did not show any indication infection with WSSV, TSV...
The Gram-negative bacteria type VI secretion system (T6SS) has been found to play an important role in interbacterial competition, biofilm formation and many other virulence-related processes. harboring T6SS inject the effectors into their recipient's cytoplasm or periplasm kill them meanwhile, avoid inhibiting itself, cognate immunity proteins were produced acts as effector inhibitor. Tae4 (type amidase 4) Tai4 are newly identified effector-immunity (EI) pairs. We have recently solved...
Escherichia coli RnlA-RnlB is a newly identified toxin-antitoxin (TA) system that plays role in bacteriophage resistance. RnlA functions as toxin with mRNA endoribonuclease activity and the cognate antitoxin RnlB inhibits toxicity E. cells. Interestingly, T4 phage encodes Dmd, which acts against to promote its own propagation, suggesting RnlA-Dmd represents novel TA system. Here, we have determined crystal structure of refined 2.10 (Dmd-binding domain), an organization not previously...