A5046528574- Congenital heart defects research
- Renal and related cancers
- Birth, Development, and Health
- Cardiac Valve Diseases and Treatments
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- Vector-Borne Animal Diseases
- Single-cell and spatial transcriptomics
- Congenital Heart Disease Studies
- Enzyme Structure and Function
- Cardiac Fibrosis and Remodeling
- Invertebrate Immune Response Mechanisms
- Vector-borne infectious diseases
- Organ Donation and Transplantation
- Fibroblast Growth Factor Research
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- CRISPR and Genetic Engineering
- Biochemical and Molecular Research
University of Oulu
2023
Washington University in St. Louis
2021-2022
The University of Texas Southwestern Medical Center
2018-2021
Institute of Macromolecular Chemistry
2013
Old Dominion University
2008
Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression cardiac transcription factors or microRNAs has recently been demonstrated. The potential clinical applicability these findings is based on the minimal regenerative adult human heart and limited availability tissue. An initial but mandatory step application this approach to establish conditions for conversion phenotype. Toward goal, we sought determine optimal combination necessary sufficient direct...
Abstract Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic structural heterogeneity are unknown. Here, we employ high-throughput bulk single-cell RNA sequencing non-lymphatic endothelial cells (ECs) to identify dictate vascular zonation from embryos adulthood. We show manifests vascular-specific signatures expressing defined transcription...
Compared to insects, little is known about innate immunity in ticks. This chapter addresses the molecular processes that recognize non-self and cellular mobilized phagocytose, engulf, inhibit or kill invaders. We discuss receptors pathogen associated patterns (PAMPs) putative up-regulation of regulatory cascades lead, ultimately, responses. describe events activate array humoral factors are against invading organisms, including antimicrobial peptides, proteases protease inhibitors, lectins,...
Proper organ development depends on coordinated communication between multiple cell types. Retinoic acid (RA) is an autocrine and paracrine signaling molecule critical to of most organs, including lung. Despite extensive work detailing effects RA deficiency in early lung morphogenesis, little known about how regulates late gestational maturation. Here, we investigate the role catabolizing protein Cyp26b1 highly enriched endothelial cells (ECs) throughout development. We find that loss leads...
Macromolecular X-ray crystallography is a robust method to understand protein functions at the molecular level, deciphering their various roles in biochemical processes. This makes teaching relevant and important for all biochemistry majors. To promote student engagement hands-on training, we have developed “Macromolecular crystallography” course where students determine structure while learning steps of technique. The implemented through Moodle, web-based Open Source platform. interactive...
ABSTRACT Proper organ development depends on coordinated communication between multiple cell types. Retinoic acid (RA) is an autocrine and paracrine signaling molecule critical for the of most organs including lung. Both RA excess deficiency lead to drastic alterations in embryogenesis, often culminating embryonic or neonatal lethality. Therefore, levels must be spatially temporally titrated ensure proper organogenesis. Despite extensive work detailing effects early lung morphogenesis,...
ABSTRACT Endothelial cells (ECs) are critical to proper heart valve development, directly contributing the mesenchyme of cardiac cushions, which progressively transform into mature valves. To date, investigators have lacked useful markers ECs fully evaluate their contributions during morphogenesis. As a result, it has been unclear whether well-characterized regional differentiation valves correlates with any endothelial domains in heart. Furthermore, difficult ascertain heterogeneity...