A5001448593- Melanoma and MAPK Pathways
- Glycosylation and Glycoproteins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Synthesis and biological activity
- Microbial infections and disease research
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Bacteriophages and microbial interactions
- Protein Kinase Regulation and GTPase Signaling
- Microbial Metabolic Engineering and Bioproduction
Texas A&M University
2015-2021
McGill University Health Centre
2019
Christie (Canada)
2019
McGill University
2015
Abstract The approval of bedaquiline (BDQ) for the treatment tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is not known precisely how BDQ triggers cell death Mycobacterium ( Mtb) . Using 13 C isotopomer analysis, we show that BDQ-treated Mtb redirects central carbon to induce metabolically vulnerable state susceptible genetic disruption glycolysis and gluconeogenesis. Metabolic flux profiles indicate dependent on ATP...
Targeting the dynamic tumor immune microenvironment can provide effective therapeutic strategies for cancer. Neutrophils (polymorphonuclear neutrophils, PMNs) are predominant circulating leukocyte population in humans and vital to fight infection. Despite mounting evidence that PMNs promote progression, depleting is not a viable option. Neutrophil extracellular traps (NETs) networks of neutrophil DNA fibers capable trapping cells promoting their growth metastasis. NETs therefore be...
Catalytic promiscuity is the coincidental ability to catalyze nonbiological reactions in same active site as native biological reaction. Several lines of evidence show that catalytic plays a role evolution new enzyme functions. Thus, studying can help identify structural features predispose an evolve This study identifies potentially preadaptive residue promiscuous N-succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) from Amycolatopsis sp. T-1-60. belongs branch OSBS family...
Stahl is a siphophage active against Bacillus megaterium, Gram-positive bacterium often used as model system in research and protein production strain industrial applications. Here, we present the complete annotated genome of phage describe its major features.
Abstract INTRODUCTION: Strong clinical evidence demonstrates a link between acute bacterial infection and metastasis. We others have shown that activation of certain membrane pattern recognition receptors (PRRs), such as Toll-like receptors, on cancer cells can be implicated in this process. There is emerging data cytoplasmic PRR, the nucleotide oligomerization domain receptor 1 (NOD1), may also play an important complementary role immune response to infection, however its progression...