A5103032175- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Organ Transplantation Techniques and Outcomes
- Neonatal and Maternal Infections
- Parasites and Host Interactions
- Pneumonia and Respiratory Infections
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Donation and Transplantation
- Congenital Diaphragmatic Hernia Studies
- Viral Infections and Vectors
- Immune Response and Inflammation
- Kawasaki Disease and Coronary Complications
- Hepatitis B Virus Studies
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Streptococcal Infections and Treatments
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Renal and Vascular Pathologies
- Neonatal Respiratory Health Research
- Autoimmune Neurological Disorders and Treatments
- Parasite Biology and Host Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Genetic Neurodegenerative Diseases
Le Bonheur Children's Hospital
2008-2017
University of Tennessee Health Science Center
2008-2017
Children's Medical Center
2008
Samsung Medical Center
1999-2003
Sungkyunkwan University
2000-2003
Respiratory syncytial virus (RSV) infection is the number one cause of bronchiolitis in infants, yet no vaccines are available because a lack knowledge infant immune system. Using neonatal mouse model, we previously revealed that mice initially infected with RSV as neonates develop Th2-biased immunopathophysiologies during reinfection, and demonstrated role for enhanced interleukin-4 receptor α (IL-4Rα) expression on T helper cells these responses. Here show induced limited type I interferon...
Respiratory syncytial virus (RSV) viral load and disease severity associate, the timing of run in parallel. An antiviral must be broadly effective against natural spectrum RSV genotypes attain concentrations capable inhibiting replication within human respiratory tract.We evaluated a novel fusion inhibitor, MDT-637, compared it with ribavirin for therapeutic effect vitro to identify relative doses achievable humans.MDT-637 were co-incubated HEp-2 cells. Quantitative PCR assessed...
Abstract Group B streptococci (GBS) are one of the leading causes life-threatening illness in neonates. Proinflammatory responses to GBS mediated through host innate immune receptors play a critical role disease manifestation. However, mechanisms involved proinflammatory against GBS, as well contribution signaling modulators defense, have not been fully elucidated. In present study, we investigated protein kinase D (PKD)1 GBS. We found that both live and antibiotic-killed induce activation...
As RNA virus mutation occurs during replication within host cells, we hypothesized that viral evolution acute infections in healthy hosts reflects immune pressure. We therefore investigated the within-host diversification of human respiratory syncytial (RSV), a highly prevalent cause infections. evaluated adults experimentally infected with an identical inoculum and infants hospitalized naturally acquired In aggregate, peaked at day 3, overrepresentation diversity matrix protein 2 (M2)...
382 Background Post transplant hepatitis B virus(HBV) infection from surface antigen (HBsAg) negative but core antibody(HBcAb) positive donors in living related liver transplants has recently been reported. Because of the high incidence HBV our country, it is necessary to identify risks using HBcAb and effective preventative regimens for posttransplant de novo infection. Patients Methods From May 1996 December 1998, thirteen consecutive living-related transplants(LRLT) were performed at...