A5091530754- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Inflammasome and immune disorders
- interferon and immune responses
- HIV Research and Treatment
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Glycosylation and Glycoproteins Research
- Lysosomal Storage Disorders Research
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Parasitic Diseases Research and Treatment
- Insect Utilization and Effects
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
- Immune cells in cancer
- Kawasaki Disease and Coronary Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chemical synthesis and alkaloids
- Hereditary Neurological Disorders
- Calpain Protease Function and Regulation
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Invertebrate Immune Response Mechanisms
National Institute of Allergy and Infectious Diseases
2020-2024
National Institutes of Health
2020-2024
Government of the United States of America
2023
Vector Oncology (United States)
2023
University of Alberta
2019-2022
Center for Research and Advanced Studies of the National Polytechnic Institute
2016-2020
Instituto Politécnico Nacional
2016-2020
Centro de Investigación en Materiales Avanzados
2018
Devi Ahilya Vishwavidyalaya
2014
Centre for Cellular and Molecular Biology
2012
One of the main phenomena occurring in cellular membranes during virus infection is a change membrane permeability. It has been observed that numerous viral proteins can oligomerize and form structures known as viroporins alter permeability membranes. Previous findings have identified such cells infected with Japanese encephalitis (JEV), member same family Dengue (DENV) belongs to (Flaviviridae). In present work, we investigated whether small hydrophobic DENV protein NS2B serves viroporin...
Gangliosides are glycosphingolipids highly enriched in the brain, with important roles cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects ganglioside biosynthetic pathway result severe neurodegenerative diseases, while a partial decrease levels of specific gangliosides was reported Parkinson's disease Huntington's disease. In models both diseases other conditions, administration GM1-one most abundant brain-provides neuroprotection. Most studies have focused on...
Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One fundamental innate immune responses to infections includes processing release pro-inflammatory cytokines such as interleukin (IL-1β IL-18) through activation inflammasome. virus stimulates Nod-like receptor (NLRP3-specific inflammasome), however, specific mechanism(s) by which dengue activates NLRP3 inflammasome unknown. In this study, we investigated in endothelial cells (HMEC-1) following...
Saliva from mosquitoes contains vasodilators that antagonize vasoconstrictors produced at the bite site. Sialokinin is a vasodilator present in saliva of Aedes aegypti. Here, we investigate its function and describe mechanism action during blood feeding. induces nitric oxide release similar to substance P. Sialokinin-KO produce lower perfusion than parental site probing have significantly longer times, which result feeding success. In contrast, there no difference between KO when using...
Journal Article Two cases of trypanosoma (Herpetosoma) species infection man in India Get access K.K. Shrivastava, Shrivastava Department Pathology and Microbiology, Medical College, Consultant Physician, Raipur (M.P.), Search for other works by this author on: Oxford Academic PubMed Google Scholar G.P. Transactions The Royal Society Tropical Medicine Hygiene, Volume 68, Issue 2, 1974, Pages 143–144, https://doi.org/10.1016/0035-9203(74)90188-6 Published: 01 January 1974
Mosquitoes inject saliva into the host skin to facilitate blood meal acquisition through active compounds that prevent hemostasis. D7 proteins are among most abundant components of mosquito and act as scavengers biogenic amines eicosanoids. Several members family have been characterized at biochemical level; however, none studied thus far in Aedes albopictus, a permissive vector for several arboviruses causes extensive human morbidity mortality. Here, we report binding capabilities long form...
Aedes aegypti mosquitoes are important vectors of several debilitating and deadly arthropod-borne (arbo) viruses, including Yellow Fever virus, Dengue West Nile virus Zika (ZIKV). Arbovirus transmission occurs when an infected mosquito probes the host’s skin in search a blood meal. Salivary proteins from help to acquire have also been shown enhance pathogen vivo vitro. Here, we evaluated interaction salivary with ZIKV by surface plasmon resonance enzyme-linked immunosorbent assay. We found...
During blood feeding, mosquitoes inject saliva into the host skin, preventing hemostasis and inflammatory responses. D7 proteins are among most abundant components of blood-feeding arthropods.
Background Salivary glands from blood-feeding arthropods secrete several molecules that inhibit mammalian hemostasis and facilitate blood feeding pathogen transmission. The salivary functions Simulium guianense , the main vector of Onchocerciasis in South America, remain largely understudied. Here, we have characterized a protease inhibitor (Guianensin) blackfly . Materials methods A combination bioinformatic biophysical analyses, recombinant protein production, vitro vivo experiments were...
Dengue virus infection (DENV-2) is transmitted by infected mosquitoes via the skin, where many dermal and epidermal cells are potentially susceptible to infection. Most of in an area will establish antiviral microenvironment control viral replication. Although cumulative studies report permissive DENV-2 dendritic cells, keratinocytes, fibroblasts, among other also infected, little information available regarding cell-to-cell crosstalk effect this on outcome Therefore, our study focused...
The PIWI-interacting RNA (piRNA) pathway provides an interference (RNAi) mechanism known from Drosophila studies to maintain the integrity of germline genome by silencing transposable elements (TE). Aedes aegypti mosquitoes, which are key vectors several arthropod-borne viruses, exhibit expanded repertoire Piwi proteins involved in piRNA pathway, suggesting functional divergence. Here, we investigate RNA-binding dynamics and subcellular localization A. Piwi4 (AePiwi4), a protein antiviral...
Mosquito borne flaviviruses such as dengue and Zika represent a major public health problem due to globalization propagation of susceptible vectors worldwide. Vertebrate host responses infections include the processing release pro-inflammatory cytokines through activation inflammasomes, resulting in disease severity fatality. saliva can facilitate pathogen infection by downregulating host's immune response. However, role mosquito modulating innate remains largely unknown. Here, we show that...
HIV-1 Nef protein is an approximately 27-kDa myristoylated that a virulence factor essential for efficient viral replication and infection in CD4+ T cells. The functions of cells are directly impeded after HIV infection. plays crucial role manipulating host cellular machinery pathogenesis by reducing the ability infected lymphocytes to form immunological synapses promoting virological with APCs, affecting T-cell stimulation. This article reviews current status Nef-mediated spread virus...
ABSTRACT Gangliosides are sialic acid-containing glycosphingolipids highly enriched in the brain. Located mainly at plasma membrane, gangliosides play important roles signaling and cell-to-cell communication. Lack of causes severe early onset neurodegenerative disorders, while more subtle deficits have been reported Parkinson’s disease Huntington’s disease, two misfolded protein diseases with a neuroinflammatory component. On other hand, administration ganglioside GM1 provides...
Blood-feeding arthropods secrete potent salivary molecules, which include platelet aggregation inhibitors, vasodilators, and anticoagulants. Among these Alboserpin, the major anticoagulant from mosquito vector Aedes albopictus, is a specific inhibitor of human coagulation factor Xa (FXa). In this study, we investigated anti-inflammatory properties in vitro vivo. vitro, Alboserpin inhibited FXa-induced protease-activated receptor (PAR)-1, PAR-2, PAR-3, VCAM, ICAM, NF-κB gene expression...
Sixty diabetic patients (15 male and 45 female) were selected from M.R .Singhal Nurshing Home of Rewa city, India.General profile, disease history, dietary pattern lifestyle related information collected by using questionnaire.Disease history to onset age diabetes, family prevalent symptom.Dietary the was know about their food habits frequency group consumption.The activity recorded type work.Anthropometric measurement like height, weight Body Mass Index recorded.The most common cause...