A5046882577- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Pharmacology and Obesity Treatment
- Marine and coastal ecosystems
- Muscle metabolism and nutrition
- Metal-Catalyzed Oxygenation Mechanisms
- Oxidative Organic Chemistry Reactions
- Marine Toxins and Detection Methods
- Vanadium and Halogenation Chemistry
- Algal biology and biofuel production
- Cardiovascular and exercise physiology
University of California, San Diego
2022-2023
Scripps Institution of Oceanography
2022-2023
Angelo State University
2013
Sea sponges are the largest marine source of small-molecule natural products described to date. Sponge-derived molecules, such as chemotherapeutic eribulin, calcium-channel blocker manoalide, and antimalarial compound kalihinol A, renowned for their impressive medicinal, chemical, biological properties. Sponges contain microbiomes that control production many isolated from these invertebrates. In fact, all genomic studies date investigating metabolic origins sponge-derived small molecules...
Domoic acid (DA), the causative agent of amnesic shellfish poisoning, is produced by select organisms within two distantly related algal clades: planktonic diatoms and red macroalgae. The biosynthetic pathway to isodomoic A was recently solved in harmful bloom-forming diatom
Vanadium-dependent haloperoxidases (VHPOs) from Streptomyces bacteria differ their counterparts in fungi, macroalgae, and other by catalyzing organohalogenating reactions with strict regiochemical stereochemical control. While this group of enzymes collectively uses hydrogen peroxide to oxidize halides for incorporation into electron-rich organic molecules, the mechanism controlled transfer highly reactive chloronium ions biosynthesis napyradiomycin merochlorin antibiotics sets...
Red algae or seaweeds produce highly distinctive halogenated terpenoid compounds, including the pentabromochlorinated monoterpene halomon that was once heralded as a promising anticancer agent. The first dedicated step in biosynthesis of these natural product molecules is expected to be catalyzed by terpene synthase (TS) enzymes. Recent work has demonstrated an emerging class type I TSs red algal biosynthesis. However, only one such enzyme from notoriously haloterpenoid-producing alga...
Background Co-ingesting creatine (5 g) with large amounts of glucose (e.g., 95 has been shown to enhance and carbohydrate storage in muscle. It speculated that transport is mediated part by insulin. The increases retention are accompanied an undesired caloric load as a result, additional research undertaken assess the effect co-ingesting nutrients may insulin sensitivity. Co-ingestion (Cr) antihyperglycemic extract Artemisia dracunculus (Russian tarragon (RT)), influence plasma Cr levels...