A5022740033- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Virology and Viral Diseases
- Global Health and Epidemiology
- Biochemical effects in animals
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- Hematological disorders and diagnostics
- Dietary Effects on Health
- Bone and Joint Diseases
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Acute Lymphoblastic Leukemia research
- COVID-19 epidemiological studies
- Cancer, Stress, Anesthesia, and Immune Response
- Phagocytosis and Immune Regulation
- GABA and Rice Research
- Iron Metabolism and Disorders
- Sirtuins and Resveratrol in Medicine
- Pancreatitis Pathology and Treatment
Imperial College London
2020-2024
Institute of Cancer Research
2021-2022
University of Oxford
2019-2021
The London College
2021
Hammersmith Hospital
2021
London Cancer
2018
University College London
2018
Sawai ManSingh Medical College and Hospital
1990-1995
Whilst access to cannabis-based medicinal products (CBMPs) has increased globally subject relaxation of scheduling laws globally, one the main barriers appropriate patient remains a paucity high-quality evidence surrounding their clinical effects.Whilst randomised controlled trials (RCTs) remain gold-standard for evaluation, there are notable implementation. Development CBMPs requires novel approaches collection address these challenges. Real world (RWE) presents solution not only both...
Pancreatic cancer has one of the worst prognoses any human malignancy and leukocyte infiltration is a major prognostic marker disease. As current immunotherapies confer negligible survival benefits, there need to better characterise leukocytes in pancreatic identify therapeutic strategies. In this study, we analysed 32 patients from two independent cohorts. A multi-parameter mass-cytometry analysis was performed on 32,000 T-cells eight patients. Single-cell RNA sequencing dataset cohort 24...
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate anticancer effects cytotoxic's such as gemcitabine. CBD therapy linked de novo synthesis ceramide. The sphingolipid ceramide is potent tumour suppressor lipid roles in apoptosis autophagy. One key players involved synthase, an enzyme six isoforms (CerS1-CerS6), reported have...
Most patients with pancreatic ductal adenocarcinoma (PDAC) are metastatic at presentation dismal prognosis warranting improved systemic therapy options. Longitudinal sampling for the assessment of treatment response poses a challenge validating novel therapies. In this case study, we evaluate feasibility collecting endoscopic ultrasound (EUS)-guided longitudinal fine-needle aspiration biopsies (FNABs) from two PDAC and conduct gene expression studies associated tumour microenvironment...
12009 Background: The lung TRACERx study is a prospective exploring the cancer genome evolution of NSCLC. Data analysis from first 100 patients enrolled into has shown an increased risk recurrence or death associated with intratumoural genomic heterogeneity. importance phylogenetic clonality neoantigens in predicting overall survival NSCLC and response to checkpoint blockade previously reported. Methods: We hypothesised that mutational burden heterogeneity reflected intra-tumoural T cell...
Abstract Pancreatic cancer has the worst prognosis of any human malignancy and leukocyte infiltration is a major prognostic marker disease. As current immunotherapies confer negligible survival benefits, there need to better characterise leukocytes in pancreatic identify therapeutic strategies. In this study, we analysed 32 patients from two independent cohorts. A multi-parameter mass-cytometry analysis was performed on 32,000 T-cells eight patients. Single-cell RNA sequencing dataset cohort...
Abstract Pancreatic cancer has the worst prognosis of any human malignancy. Our recent work shown that immune infiltrate by transcriptomics and histopathology can predict after a Whipple’s operation, with lymphocyte infiltration being most important prognostic marker. We have profiled T cells within primary pancreatic to understand T-cell architecture tumor. used 37-marker cell-focused panel study infiltrate. see diverse immunosuppressive microenvironment There is complex macrophages,...
Abstract Background: Pancreatic cancer has the worst prognosis of any human malignancy. We have shown using transcriptomics and histopathology that immune infiltrate in resection samples from a Whipple’s operation is predictive prognosis. In particular, lymphocytes appear to be major prognostic marker. With promising immunotherapies being proposed for other cancers, there need deeper understanding landscape pancreatic identify points intervention. Methods: developed 37-marker mass cytometry...
Abstract Background Most patients with pancreatic ductal adenocarcinoma (PDAC) are metastatic at presentation dismal prognosis warranting improved systemic therapy options. Longitudinal sampling for assessment of treatment response poses a challenge validating novel therapies. In this feasibility study, we evaluate the role endoscopic ultrasound (EUS)-guided serial fine-needle aspiration biopsies (FNABs) to study molecular changes associated radiofrequency ablation (RFA). Methods Two stage...
Abstract Background: Most patients with pancreatic ductal adenocarcinoma (PDAC) are metastatic at presentation dismal prognosis warranting improved systemic therapy options. Longitudinal sampling for assessment of treatment response poses a challenge validating novel therapies. In this proof-of-principle study, we evaluate the role endoscopic ultrasound (EUS)-guided serial fine-needle aspiration biopsies (FNABs) to study mechanism action radiofrequency ablation (RFA). Methods: Patients stage...
This study was conducted in 1985-86 amongst non-hospitalized children of jaipur city in33 investigative units having 3791 families with 6183 the 0-9 years age group. Measles vaccine coverage only 21.7% developed 189 cases. Maximum incidence occurred 1-2 olds and during first half (January to June). Complication 50 (26.5%) children. The most frequent diarrohea (14.3%) followed by respiratory infection (6.9%). No case fatality reported.