A5040483882- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Amyloidosis: Diagnosis, Treatment, Outcomes
- T-cell and Retrovirus Studies
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cutaneous lymphoproliferative disorders research
- Thermal Regulation in Medicine
- Inflammation biomarkers and pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Skin Diseases and Diabetes
- Retinoids in leukemia and cellular processes
- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
- Inflammatory Myopathies and Dermatomyositis
- Physiological and biochemical adaptations
- Parathyroid Disorders and Treatments
- Cancer Cells and Metastasis
- Bone and Dental Protein Studies
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and biosynthesis
University of British Columbia
2013-2024
Vancouver General Hospital
2021-2024
University of Calgary
2010-2011
University of Leeds
1985
Abstract Due to evolving treatment standards for newly diagnosed multiple myeloma, many patients will be triple-class exposed after initial relapses and have poor survival. Novel therapies combinations are therefore required improve outcomes. B cell maturation antigen (BCMA)-targeted biologics emerged as an important new area of therapeutics relapsed myeloma. The two-part ALGONQUIN trial evaluated various doses schedules the anti-BCMA antibody–drug conjugate belantamab mafodotin plus...
Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccination. In British Columbia (BC), Canada, provincial clinical care pathway was developed to guide clinicians in evaluating for VITT among patients who present with or thrombosis symptoms within 4 28 days vaccine exposure. All had enzyme-linked immunosorbent assay (ELISA) testing platelet factor (PF4) antibodies,...
Background Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication of the ChAdOx1 nCoV-19 and Ad26.COV2.S COVID-19 vaccines. It presents most commonly with severe complications extremely high D-dimer levels 5–30 days after vaccination. We report patient who presented mild minimally elevated without thrombosis, but tested positive for antiplatelet factor 4 (PF4) platelet-activating antibodies on PF4-enhanced serotonin-release assay. Key Clinical Question Is...
A 65-year-old male presenting with chest pain and unintentional weight loss was found to have normocytic anemia (hemoglobin of 107 g/L). Endoscopy revealed features gastritis biopsies from the stomach duodenum showed amyloid deposits as demonstrated by histological examination Congo red staining. Serum protein electrophoresis detected a small band measuring 0.8 g/L at gamma region which identified an IgD lambda monoclonal immunofixation (panel A). Free light chains were in urine. kappa free...