Ultrasound-stimulated contrast agents have gained significant attention in the field of tumor treatment as drug delivery systems. However, their limited drug-loading efficiency and issue bulky, imprecise release resulted inadequate concentrations at targeted tissues. Herein, we developed a highly efficient approach for doxorubicin (DOX) precise site real-time feedback via an integrated strategy "programmable ultrasonic imaging guided accurate nanodroplet destruction release" (PND). We...

Antifungal hydrogels with added antifungal drugs have received extensive attention from researchers due to their potential use in various applications, such as wound dressings and ultrasound gel pads. In this study, we proposed designed an alternative hydrogel preparation strategy obtain high abilities. We employed plasma-activated water (PAW) instead of the polymerization process prepare (PAHs). Disc diffusion assay results revealed that PAH exhibits satisfactory activity. Interestingly,...

A flexible hydrogel pressure distribution sensor has promising application prospects. However, the current sensors are based on an array-type structure with complicated wires and extremely low resolution, which greatly reduce flexibility of limit their applications. To overcome these limitations, we proposed designed a that is able to obtain inside whole piece hydrogel. This specifically done by arranging electrodes only around hydrogel, employs strategy electrical impedance tomography...

Hydrosulfonylation of alkenes with readily available aromatic iodides via a SO2-insetion strategy is presented. The combination non-noble Ni catalysis (iPr)3SiH as the final reductant enables efficient formation aryl and heteroaryl sulfinate intermediates, which undergo Michael-type additions to electron-deficient for initiating hydrosulfonylation process. Moreover, superiority this protocol demonstrated by broad substrate scope good functional group compatibility.

Abstract Background Enterococcus faecalis ( E. ) is the most frequently isolated bacteria from teeth with root canal treatment failure. This study aims to evaluate disinfection effect of ultrasonic-mediated cold plasma-loaded microbubbles (PMBs) on 7d biofilm, mechanical safety and mechanisms. Methods The PMBs were fabricated by a modified emulsification process key reactive species, nitric oxide (NO) hydrogen peroxide (H 2 O evaluated. biofilm human tooth disk was constructed divided into...

As a promising non-invasive technique, functional near-infrared spectroscopy (fNIRS) can easily detect the hemodynamic responses of cortical brain activities. This paper investigated multiclass classification motor imagery (MI) based on fNIRS; ten healthy individuals were recruited to move an object using their imagination. A multi-channel continuous-wave fNIRS equipment was applied obtain signals from prefrontal cortex. combination ensemble empirical mode decomposition and independent...

As one of the most valuable endogenous gas signaling molecules, carbon monoxide (CO) has been demonstrated in numerous studies to show excellent promise treatment diseases, such as cancer. However, for many years, inherent high affinity CO hemoglobin severely impeded clinical transformation CO-based treatments. Therefore, controlled delivery target tissues become a common challenge. Herein, an efficient ultrasonic-triggered and targeted release strategy was constructed based on novel...

The discharge of azo dyes causes great harm to humans and the environment. Azo can be degraded by a heterogeneous Fenton reaction catalyzed α-FeOOH nanorods. However, because large size conventional goethite nanorods, rate is limited. In this study, we proposed template method strategy for synthesizing ultrasmall nanorods (SFNs) investigated their use catalyzing degradation an dye, methyl orange (MO). Transmission electron microscopy results suggested that sizes SFNs are much smaller than...

Biomedical imaging technology (like digital subtraction angiography (DSA)) based on contrast agents has been widely employed in the diagnosis of vascular-related diseases. While DSA achieves high-resolution observation specified vessels and their downstream perfusion at cost invasive, radioactive operation hepatorenal toxicity. To address those problems, this study develops arterial labeling ultrasound (US) (ALUSA) a new perfluorobutane (PFB) nanodroplets with lower vaporization threshold...

Electrospun microfibers, designed to emulate the extracellular matrix (ECM), play a crucial role in regulating cellular microenvironment for tissue repair. Understanding their mechanical influence and inherent biological interactions at ECM interface, however, remains complex challenge. This study delves into of cues repair by fabricating Col/PLCL microfibers with varying chemical compositions alignments that mimic structure ECM. Furthermore, we optimized these create Col/PLCL@PDO aligned...

The widespread application of photocatalysis for converting solar energy and seawater into hydrogen is generally hindered by limited catalyst activity the lack sustainable large-scale platforms. Here, a multi-scale hierarchical organic photocatalytic platform was developed, combining photosensitive molecular heterojunction with molecular-scale gradient level alignment micro-nanoscale pore structures. ternary system facilitates efficient charge transfer enhances compared to conventional...

Conventional methods used to control bacterial biofilm infection in root canals have poor efficacy, causing repeated and chronic infections, which pose a great challenge clinical treatment. Microbubbles, due their small size ultrasound (US)-enhanced cavitation effects, attracted considerable attention. They possess the potential for therapeutic application restricted spaces. We address above problem with strategy space of canals. Herein, phase-change nanodroplets (P-NDs) exposed US are...

Super-resolution ultrasound (SRUS) imaging has been gradually employed for the non-invasive evaluation of tumor intervention, while comprehensive indicators such as vessel density (VD), tortuosity (VT) and velocity (VV) could easily conceal local changes heterogeneous microvasculature. Herein, our study attempts to construct novel monitor manner microvascular verify its non-invasion quantitative response during intervention. Tumors were delineated into central peripheral regions based on...

Abstract The widespread application of photocatalysis for converting solar energy and seawater into hydrogen is generally hindered by limited catalyst activity the lack sustainable large‐scale platforms. Here, a multi‐scale hierarchical organic photocatalytic platform was developed, combining photosensitive molecular heterojunction with molecular‐scale gradient level alignment micro‐nanoscale pore structures. ternary system facilitates efficient charge transfer enhances compared to...

Ultrasound without ionizing radiation has been shown to have excellent sensitivity and specificity in the diagnosis of hand fractures, which is used replace X-ray CT emergency department. The water bath technology further solves problem suboptimal contact between ultrasonic transducer skin, but flow caused by movement probe produces severe artifacts. In addition, open wounds are not allowed be placed water. this study, we produce a hydrogel glove with acoustic impedance matching combine...

Cold atmospheric plasma (CAP) is expected to be a novel anti-cancer therapy strategy that has much less drug resistance or side effects. However, how effectively deliver CAP target lesion in vivo still challenging. In this paper we design and prepare kind of stable CAP/C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> F xmlns:xlink="http://www.w3.org/1999/xlink">8</inf> MBs for image-guided controllable delivery vivo, verify their...

The ultrasound field design has great potential as an encoder of super-resolution method, the structured been proposed in recent years. However, only convex array probes are used acoustic illumination currently, and sound designed is inconsistent with commonly light moire fringe stripes. In this work, we propose a generation method for based on linear probe. We improve Gerchberg-saxton algorithm constrained optimization matching degree smoothness provide new reconstruction strategy weights...

Achilles tendon (AT) injuries constitute 8-20% of sports-related in disciplines such as ball sports, track and field. Current diagnosis AT mainly relies on MRI musculoskeletal ultrasound. In recent years, portable ultrasound devices have enabled rapid injury detection right the sidelines sports fields. However, ultrasound-based necessitates non-planar scanning depends proficient clinicians to identify with repetitive affected area. this study, we introduce an elastic Hydrogel Boot that...