A5054765192- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- COVID-19 diagnosis using AI
- Pharmacological Effects and Assays
- Mitochondrial Function and Pathology
- Allergic Rhinitis and Sensitization
- Delphi Technique in Research
- Metabolism and Genetic Disorders
- Hemodynamic Monitoring and Therapy
- Coenzyme Q10 studies and effects
McGill University
2011-2025
McGill University Health Centre
2016-2025
Lakeshore General Hospital
2021-2025
Christie (Canada)
1993-2025
Ste. Anne's Hospital
2025
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2017-2021
Centre intégré universitaire de santé et de services sociaux de l'Ouest-de-l’Île-de-Montréal
2019
Woman's Hospital
2016
Harvard University
2016
American College of Chest Physicians
2015
We followed 16 patients with a variety of mitochondrial diseases over one to four periods treatment (2 months each) coenzyme Q<sub>10</sub> plus vitamins K<sub>3</sub> and C, riboflavin, thiamine, niacin, using independent measures oxidative metabolism assess efficacy. There were large (<threefold) increases in serum concentrations treatment, but no measure showed significant improvement for the group, nor did any individual patient show significant, reproducible, objective clinical...
Noninvasiveness, low cooperation demand and the potential for detailed physiological characterisation have promoted use of oscillometry in assessment lung function. However, concerns been raised about comparability measurement outcomes delivered by different devices. The present study compares performances oscillometers mechanical test loads with without simulated breathing. Six devices (five were commercially available one was custom made) tested combining resistors ( R ), gas compliances C...
Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma–COPD overlap (ACO). There is paucity information about ACO in primary care.Objectives: To estimate the prevalence describe individuals with care practices among patients currently diagnosed asthma, COPD, or both; to compare three source populations.Methods: The Respiratory Effectiveness Group conducted cross-sectional study ≥40 years old ≥2...
We used a modified adult lung explant technique to directly measure the area of individual airways before and after methacholine (MCh) administration. Lungs were removed from 12-wk-old male Lewis rats under sterile conditions, filled with an agarose-containing solution at 37 degrees C, cooled 4 C. Transverse slices (0.5–1.0 mm thick) cut cultured overnight. Concentration-response curves MCh determined for lungs inflated 25, 50, 75, 100% total capacity (TLC) 1.0% agarose 75% TLC 0.5 2.0%...
Developed over six decades ago, pulmonary oscillometry has re-emerged as a noninvasive and effort-independent method for evaluating respiratory-system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized 3He ventilation-defect-percent (VDP) resistance, reactance area (AX) measurements 175 participants including 42 never-smokers without respiratory disease, 56 ex-smokers chronic-obstructive-pulmonary-disease (COPD), 28 COPD 49...
While conventional spirometry is associated with strenuous "forced" maximal respiratory maneuvers and infection control implications, oscillometry not these issues. However, portability, convenience of use, interpretation remain common limitations to both techniques. This study tested the concordance agreement between resistance measurements obtained from handheld portable REOM device (Reo-f, Reo-s) those (R19, R5) in PFT-confirmed "mild" (GOLD 1) "very severe" 4) COPD. Unadjusted adjusted...
Oscillometry is gaining in clinical use and while there an increased interest the technique, paucity understanding of its possibilities limitations. has seen extensive research over several decades, but only recently technique being adopted practice; hence, a need to educate novel users. The goal mini symposium arranged San Diego 2018 was discuss principles oscillometry, showcase some recent ongoing using this demonstrate how oscillometry may be used practice. It concluded that advantages...
Purpose: To test whether the mean curvature of isophotes (MCI), a geometric image transformation, can be used to improve automatic detection on chest CT Usual Interstitial Pneumonia (UIP), determining radiological pattern in diagnosis Lung Diseases (ILD). Materials and methods: This retrospective study included scans from 234 patients (123 female,111 male; age: 61.6 years; age range: 18-90 years) obtained at two independent institutions between 2007 2024. Three different classification...
Intra-breath oscillometry (IBOsc) is an emerging approach to characterize dynamic changes in respiratory mechanical impedance (Zrs). IBOsc utilizes a small-amplitude sinusoidal signal superimposed on quiet breathing track Zrs with sufficient temporal resolution find specific time points, such as end-expiration (eE) and end-inspiration (eI). has demonstrated superiority conventional multifrequency detecting abnormal function predicting future impairment several clinical settings. The aim of...
This study described the participation in daily and social activities perceived barriers facilitators to of individuals with chronic obstructive pulmonary disease (COPD). Individuals, recruited from outpatient clinics, responded a survey on their in, towards, 26 activities, divided into 3 categories: (1) physical activity movement (PAM); (2) self-care; (3) engagement. For each activity, chi-square analyses were used examine differences by individuals': quartiles airflow obstruction [percent...
Abstract Background Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they frequently overprescribed. ICS withdrawal has been recommended by international guidelines order to prevent side effects whom not indicated. Method Observational comparative effectiveness study aimed evaluate the effect versus continuation triple therapy (TT) COPD primary care. Data were obtained from Optimum Patient Care Research Database (OPCRD) UK. Results A...
Wang, C. G., J. Almirall, S. Dolman, R. Dandurand, and D. H. Eidelman. In vitro bronchial responsiveness in two highly inbred rat strains. Appl. Physiol. 82(5): 1445–1452, 1997.—We investigated methacholine (MCh)-induced bronchoconstriction explanted airways from Fischer Lewis rats. Lung explants, 0.5- to 1.0-mm thick, were prepared agarose-inflated lungs of anesthetized 8- 12-wk-old male After overnight culture, videomicroscopy was used record baseline images the individual airways....
The ovalbumin (OA)-sensitized Brown Norway rat (BN) demonstrates early-response (ER) and late-response (LR) allergic bronchoconstriction. To determine whether these responses could be replicated in vitro, we studied lung explants from 8-wk-old male BN rats (wt: 239 +/- 28 g), of which 19 were sensitized to OA (test) 16 served as controls. Two weeks after sensitization, the animals' lungs removed, filled with a 1% (wt/vol) agarose-containing solution at 37 degrees C, cooled 4 C. Transverse...
<h3>BACKGROUND:</h3> The guidelines to conduct and interpret conventional pulmonary function (PFT) tests are frequently reviewed updated. However, the quality assurance control (QA/QC) for respiratory oscillometry testing remain limited. QA/QC essential be used as a diagnostic test in clinical setting. <h3>METHODS:</h3> We developed protocol shortly after was introduced our laboratory part of study. first study began research personnel completed 3 h combined didactic hands-on training...
Several lines of evidence suggest that the responsiveness airways is heterogeneous, although magnitude this heterogeneity has not been quantified. We have developed a videomicroscopic method allows measurements individual explanted to contractile agonists such as methacholine. Liquid agarose at 37 degrees C injected into human lung segments inflate them volume equivalent total capacity. The agarose-filled lungs are then gelled by brief refrigeration and 0.5-mm-thick explants prepared...
To investigate if airway-parenchymal interdependence may account for differing bronchial responsiveness between inbred rat strains, Fisher and Lewis 12-wk-old male rats were anesthetized, tracheostomized, placed in a pressure plethysmograph. Functional residual capacity, total lung capacity [lung volume at transpulmonary (PL) of 30 cmH2O], specific compliance determined found to be similar. Rats paralyzed mechanically ventilated. Concentration-response curves constructed by calculating...
To develop a method for the study of mucociliary clearance in small-caliber airways, we investigated ciliary function an vitro lung tissue culture technique mice. Lungs were excised from 45 anesthetized mice [weight 30.9 +/- 6.2 (SD) g] and inflated with 2% liquid agarose at 37 degrees C via trachea. After cooling to 4 C, lungs cut into 0.5- 1.0-mm thick slices cultured overnight. Ciliary beat frequency (CBF) was measured airways cross section using computerized image processing system. In...