About
Contact & Profiles
A5027132554
Research Areas
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
University of Pennsylvania
2023
10.1016/j.molcel.2023.10.035
article
EN
Molecular Cell
2023-11-22
ABSTRACT The metazoan-specific Integrator complex catalyzes 3’ end processing of small nuclear RNAs (snRNAs) as well premature transcription termination events that attenuate expression many protein-coding genes. has RNA endonuclease and protein phosphatase activities, but it remains unclear if both are always required for function. Here, we show IntS6 (Integrator subunit 6) over-expression is sufficient to block function at a subset Drosophila genes, while having no effect on snRNA or...
10.1101/2023.03.05.531184
preprint
EN
cc-by-nc
bioRxiv (Cold Spring Harbor Laboratory)
2023-03-05
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