A5028903085- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Shoulder Injury and Treatment
- Cancer-related gene regulation
Marquette University
2023
Vanderbilt University
2023
Bridge University
2023
Towson University
2023
University of Nebraska–Lincoln
2023
University of Pittsburgh
2023
The University of Texas at Austin
2023
University Hospital of Zurich
2022
Massachusetts General Hospital
2009-2018
Harvard University
2009-2018
Clinical protocols utilize bone marrow to seed synthetic and decellularized allogeneic grafts for enhancement of scaffold remodeling fusion. Marrow-derived cytokines induce host neovascularization at the graft surface, but hypoxic conditions cause cell death core. Addition cellular components that generate an extensive primitive plexus-like vascular network would perfuse entire upon anastomosis could potentially yield significantly higher-quality grafts. We used a mouse model develop...
To investigate the effect of DAPT (γ‐secretase inhibitor) on growth human tongue carcinoma cells and to determine molecular mechanism enable potential application treatment carcinoma. Human Tca8113 were cultured with DAPT. Cell was determined using Indigotic Reduction method. The cell cycle apoptosis analyzed by flow cytometry. Real‐time PCR Immuno‐Fluorescence (IF) employed intracellular expression levels. inhibited inducing G0–G1 arrest apoptosis. mRNA levels Hairy/Enhancer Split‐1...
Abstract Objectives Creation of functional, durable vasculature remains an important goal within the field regenerative medicine. Engineered biological has potential to restore or improve human tissue function. We hypothesized that pleotropic effects insulin‐like growth factor 1 ( IGF 1) would enhance engineering capillary‐like vasculature. Materials and methods The impact upon vasculogenesis was examined in vitro cultures for a period up 40 days as subcutaneous implants immunodeficient...