A5102908207- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- CAR-T cell therapy research
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Streptococcal Infections and Treatments
- Hepatitis B Virus Studies
- Chemotherapy-related skin toxicity
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Enterobacteriaceae and Cronobacter Research
- Orthopedic Infections and Treatments
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- Actinomycetales infections and treatment
- Nail Diseases and Treatments
- Histone Deacetylase Inhibitors Research
- Transplantation: Methods and Outcomes
- Disaster Response and Management
- Advanced Breast Cancer Therapies
Medical University of South Carolina
2018-2022
University of Virginia Health System
2013-2018
Virginia Commonwealth University Medical Center
2017
University of Virginia
2016-2017
Presbyterian Hospital
2015
New York Hospital Queens
2015
NewYork–Presbyterian Hospital
2015
Cornell University
2013-2015
Creative Research Enterprises (United States)
2015
St. Francis Xavier University
2011
Mantle-cell lymphoma is generally incurable. Initial treatment not standardized but usually includes cytotoxic chemotherapy. Lenalidomide, an immunomodulatory compound, and rituximab, anti-CD20 antibody, are active in patients with recurrent mantle-cell lymphoma. We evaluated lenalidomide plus rituximab as a first-line therapy.We conducted single-group, multicenter, phase 2 study induction maintenance phases. During the phase, was administered at dose of 20 mg daily on days 1 through 21...
Background. Daptomycin has become a front-line antibiotic for multidrug-resistant Enterococcus faecium bloodstream infections (BSIs). We previously showed that E. strains with daptomycin minimum inhibitory concentrations (MICs) in the higher end of susceptibility frequently harbor mutations associated resistance. postulate patients BSIs exhibiting MICs 3–4 µg/mL treated are more likely to have worse clinical outcomes than those ≤2 µg/mL. Methods. conducted multicenter retrospective cohort...
Thirty-eight (51%) of 75 patients treated with CHOP for diffuse histiocytic lymphoma achieved complete remission. Twenty-three the responders are currently alive in remission 24-78 months (median, 38 months) after discontinuing therapy. Eleven died from recurrent and four other causes. Evaluation 23 found them mostly well without serious sequelae to Comparison 20 who were same age range, disease free surgery, had no therapy colon cancer revealed only an increased frequency sexual dysfunction...
Objective We describe the efficacy of enhanced infection control measures, including those recommended in Centers for Disease Control and Prevention’s 2012 carbapenem-resistant Enterobacteriaceae (CRE) toolkit, to concurrent outbreaks carbapenemase-producing (CPE) extensively drug-resistant Acinetobacter baumannii (XDR-AB). Design Before-after intervention study. Setting Fifteen-bed surgical trauma intensive care unit (ICU). Methods investigated impact measures response clusters CPE XDR-AB...
The purpose was to determine if creatine supplementation, consumed immediately before and after exercise, with different dosing frequency (i.e., 2 or 3 d wk) could enhance the gains in muscle size strength from resistance training (RT) young adults. A group of 38 physically active, nonresistance trained university students (21-28 years) randomly allocated 1 4 groups: CR2 (0.15 g·kg during wk RT; sets 10 repetitions; n = 11, 6 men, 5 women), CR3 (0.10 women;), PLA2 (placebo 8, PLA3 women) for...
Abstract Background Infections caused by vancomycin‐resistant Enterococcus faecium ( VRE ) are a major cause of morbidity and mortality in the liver transplant population. Daptomycin DAP is often used to treat infections , but nonsusceptibility increasing. Method Patients with ‐nonsusceptible DNSE who had undergone transplantation between January 1, 2010 July 31, 2014 were retrospectively reviewed. A convenience sample isolates was analyzed pulsed‐field gel electrophoresis PFGE ). Results We...
Carbapenemase-producing Enterobacteriaceae (CPE) are of increasing prevalence worldwide, and long-term acute care hospitals (LTACHs) have been implicated in several outbreaks the United States. This prospective study routine screening for CPE on admission to a LTACH demonstrates high colonization central Virginia.
Risk factors for acquisition of vancomycin-resistant Enterococcus (VRE) include immunosuppression, antibiotic exposure, indwelling catheters, and manipulation the gastrointestinal tract, all which occur in liver transplant recipients. VRE infections are documented transplantation (LT); however, only one single center study has assessed impact daptomycin-resistant (DRE) this patient population.We conducted a retrospective multicenter cohort comparing recipients with either or DRE bacteremia....
An accepted practice for patients colonized with multidrug-resistant organisms is to discontinue contact precautions following 3 consecutive negative surveillance cultures. Our experience cultures detect persistent carbapenemase-producing Enterobacteriaceae (CPE) colonization suggests that extrapolation of this CPE-colonized may not be appropriate. Infect Control Hosp Epidemiol 2015;36(7):835–837
Vancomycin-resistant Enterococcus faecium (VRE) infections are common in liver transplant recipients (LTRs). Daptomycin (DAP) is an important treatment for such infections; however, DAP-nonsusceptible VRE (DNS-VRE) increasingly frequent. The purpose of this study was to compare clinical characteristics and outcomes LTRs with due DNS-VRE DAP-susceptible (DS-VRE).A single center, retrospective review patients who underwent transplantation between January 1, 2010 December 31, 2015 developed...
(1) Background: Vaccination of solid organ transplant (SOT) candidates and recipients is vital to decrease infection-related morbidity mortality. Here we describe our heart lung programs' rates completion hepatitis B pneumococcal vaccinations identify potential opportunities for improvement. (2) Methods: This a single-center retrospective study that included all between 1 July 2013 31 2018. We assessed demographics, causes failure, pretransplant immune status, vaccine series, conjugate...
Twenty percent of patients with acute myeloid leukemia (AML) undergoing induction or reinduction chemotherapy at the University Virginia Health System from May 2011 to August 2014 had a proven probable invasive fungal infection (IFI). The purpose our initiative was reduce percentage IFIs in AML 10% less by June 2017, concordance national averages.
Anthropophilic dermatophyte infection is one of the most commonly encountered skin and nail pathologies. Invasive disease occurs in immunocompromised individuals through follicular invasion, traumatic infiltration, or localized infiltration pathologies inducing epithelial barrier disruption. It typically presents as purplish ulcerated nodules lower extremities, but corporal manifestations vary extent appearance, ranging from scaly plaques to tumor-like pseudocysts, vegetative nodules,...