A5033813011- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Otitis Media and Relapsing Polychondritis
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Infections and Treatments
- Viral Infections and Immunology Research
- Vasculitis and related conditions
- Peripheral Neuropathies and Disorders
- Chronic Lymphocytic Leukemia Research
- Nutrition and Health in Aging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Orthopaedic implants and arthroplasty
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Dermatological and COVID-19 studies
- Biosimilars and Bioanalytical Methods
- Traditional Chinese Medicine Studies
- Immunotherapy and Immune Responses
- Spondyloarthritis Studies and Treatments
- Parvovirus B19 Infection Studies
- Inflammatory Myopathies and Dermatomyositis
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2025
University of Pavia
2012-2025
Policlinico San Matteo Fondazione
2020-2025
To delineate, within the framework of current clinical practice and criteria, sustainability first-line immuno-suppressive treatment discontinuation in rheumatoid arthritis (RA) impact residual disease remission on long-term drug-free (DF) outcomes. RA patients, referring to Pavia early clinic (EAC) between 2009 2021 achieving after Disease Activity Score-driven methotrexate (MTX) monotherapy, were recruited. Eligible patients underwent DF follow-up at 3-month intervals over 5 years MTX...
Abstract Objectives Autoantibody-negative RA differs from autoantibody-positive in several clinical aspects, possibly underpinned by pathogenetic differences. At present, the role of adaptive immune responses autoantibody-negative remains unclear. Here, we investigated synovial and serum immunophenotype indicative B lymphocyte involvement across spectrum -negative chronic arthritides. Methods Ultrasound-guided biopsies were retrieved 131 patients: 43 RA, 35 25 polyarticular PsA 28...
The patient global assessment of disease activity (PGA) is the major limiting factor to Boolean remission in patients with established rheumatoid arthritis (RA). Here, we investigated variables early RA treated conventional synthetic modifying anti-rheumatic drugs, also relation autoantibody status.Data were retrieved from 535 (<12 months symptoms) an observation period 6-12 upon initiation therapy methotrexate aimed at achievement low based on 28-joints score. Near-remission was defined as...
A proof-of-concept study to evaluate the feasibility and safety of minimally invasive ultrasound (US)-guided synovial biopsy radiocarpal (RC) joint using anatomical snuffbox as an access route.Twenty consecutive patients with active chronic arthritis wrist underwent US-guided RC route. Samples were retrieved from 3 predetermined target sites synovia (proximal, vault, distal site), aiming for a minimum 12 samples. The procedure's was evaluated based on number histological quality tissue...
<h3>Background:</h3> Raman spectroscopy (RS) is a sensitive molecular technique that allows capturing the vibrational modes of chemical bonds in materials through emission photons at specific wavelengths and recording their inelastic scattering properties. These properties have attracted considerable interest exploitation RS for analysis biological tissues, as tool to dissect sensitively widespread changes within cells extracellular matrix, relying on limited amount tissue. Despite initial...
<h3>Background</h3> C-X-C motif chemokine ligand 13 (CXCL13) is a involved in the recruitment of B cells secondary lymphoid organs and ectopic inflamed sites. Recent studies animals models healthy individuals have shown that serum levels CXCL13 correlate with GC activity after immunization, pointing at their role as an early biomarker adaptive immune response. In rheumatoid arthritis (RA) systemic expression has been to be upregulated. However, factors upregulation its significance putative...
Background The phase preceding the development of rheumatoid arthritis (RA) may contain a novel window opportunity for disease prevention and control. Investigation this at population level remain, however, very challenging in epidemiological terms due to rarity events. Patients seeking medical attention with arthralgia at-risk, defined by an expert rheumatologist (clinically suspect arthralgia, CSA) or recent EULAR definition represent attractive platform identification both seropositive...
Background The mechanisms of flare across the pathogenic spectrum RA remain unclear. To what extent reproduces dynamics disease onset or is primarily driven by new not known. Furthermore, hypothesis a role for circulating auto-antibodies in determining different mechanism behind has never been challenged. Objectives evaluate whether after remission achievement phenotype it characterized pattern residual joint injury treatment, ACPA positive and negative patients. Methods 53 patients, stable...
Background: The outcomes of patients with chronic inflammatory arthritis (IA), such as rheumatoid (RA), have dramatically improved over the past 20 years. Earlier identification IA and prompter treatment institution been key advancements, promoted by constitution Early Arthritis Clinics (EAC) development more sensitive classification criteria for RA. outbreak new COronaVIrus Disease 2019 (COVID-19) has quickly become a global health emergency forced rearrangement in management other...