Introduction. The development of malignant neoplasms (MNs) in people who have worked contact with industrial aerosols is a complex mechanism associated exposure to carcinogens and chronic occupational respiratory diseases, including obstructive pulmonary disease (COPD). heterogeneity occupational-related suggests differences the predisposition oncogenesis. study aims determine clinical, functional, cellular-molecular characteristics OCOPD combination neoplasm (MN). Materials methods. Design:...

BACKGROUND: Features of vascular changes in occupational chronic obstructive pulmonary disease (COPD) phenotypes, significance for its development impact different components industrial aerosols, particularly nanoparticles are not studied enough. AIM: was to establish features remodelling and endothelial function subjects with COPD due exposure aerosols containing MATERIALS AND METHODS: It an observational cohort cross-sectional study metal (n=48) or silica (n=55) comparison tobacco smokers...

Introduction. Health care workers are at risk of infection with the SARS-CoV-2 virus. However, many aspects professionally conditioned COVID-19 still poorly understood. The aim study is to conduct a brief review and analysis scientific data on prevalence, features clinical laboratory syndromes in medical professionals. To evaluate structure post-COVID syndrome health who observed large multidisciplinary organization that has center for occupational pathology. present current state problem...

The significant prevalence of industrial aerosols with unintentional nanoparticles and the increasing use engineering in modern production determine relevance research on patterns interaction human bronchopulmonary system. Unintentional are formed during various processes: melting welding metals, combustion, crushing, grinding minerals, plasma processing materials. Engineering released into air work area their or any technological processes. respiratory system, as a barrier organ, is most...

Abstract Introduction There is unmet need in novel predictors of occupational chronic obstructive pulmonary disease (COPD) for risk management improvement. The aim the study was to investigate inflammatory factors associated with exposure nanoparticles – less investigated industrial aerosols’ component, and reveal potential markers. Methods It a prospective observational study. Nanoparticles at workplaces air machine manufacturing facility were by scanning electron microscopy inductively...

Abstract Introduction Healthcare workers (HCW) were at the frontline of COVID-19 pandemic. Currently burning issue for this occupational group is chronic post-COVID-19 syndrome that leads to work disability. The study aim was reveal severity and predictors pulmonary fibrosis (PF) in HCW with syndrome. Methods An observational prospective over a 3-years period conducted. COVID-19, confirmed by polymerase chain reaction (PCR) included (n=152). After 4 months, 56 patients continued study. Using...

<b>Background:</b> Occupational chronic obstructive pulmonary disease (COPD) is major health consequence of workplace inhalation dust. Less known about influence incidental nanoparticles on COPD pathogenesis and phenotype. <b>Objective:</b> To evaluate the main monocyte subpopulations in from exposure to industrial aerosols, containing reveal associations with <b>Methods:</b> subjects, 20 exposed aerosol, 25 tobacco smokers enrolled. Controls - healthy people. Groups were matched by age,...

Introduction. Influence of incidental nanoparticles industrial aerosols on occupational lung diseases development is not studied enough. As has properties to induce inflammation and fibrosis, it hypothesized that they affect chronic obstructive pulmonary disease (COPD) phenotype. The aim was establish monocyte subsets, airway inflammation, clinical functional features in COPD due containing exposure. Materials methods. Study design a single center prospective cohort observational. Subjects...

Introduction . Inflammation in viral-induced acute exacerbations of chronic obstructive pulmonary disease (COPD) is not studied enough. The aim was to establish molecular pattern inflammation (AECOPD) comparison with bacterial AECOPD and reveal associations phenotype subsequent COPD progression. Materials methods Subjects hospitalized which 60 were viral, viral-bacterial recruited single center prospective (52 weeks) cohort study. Control group – 30 healthy people. diagnosed previously...

The article presents evolutionary changes in occupationally related nonspecific and specific hematologic syndromes, occupational chronic intoxications blood diseases due to contact with various hazards mostly hematotropic ones, depending on length of service. presented characteristics cover microelement disorders during primary diagnosis post-contact period. Findings areless chemical influences.

Aim. To establish the efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) for healthcare workers protection from occupational acquired infection and impact staff vaccination on risk transmission to patients. Materials methods. Healthcare personnel (n=157 whom 105 critical care department staff) 1770 patients that observed. received PCV13. Infections caused by Str. pneumoniae, respiratory infections regardless etiology, work absenteeism in during 12 month before after assessed. In...

To establish the efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) for healthcare workers protection from occupational acquired infection and impact staff vaccination on risk transmission to patients.Healthcare personnel (n=157 whom 105 critical care department staff) 1770 patients that observed. Healthcare received PCV13. Infections caused by Str. pneumoniae, respiratory infections regardless etiology, work absenteeism in during 12 month before after assessed. In same time...

Aim. To study the characteristics of direct oral anticoagulant-related bleeding in patients with heart failure combination chronic obstructive pulmonary disease (COPD) and atrial fibrillation. show efficacy idarucizumab complex therapy severe gastrointestinal caused by dabigatran. Material methods. The single-center prospective observational included 150 nonvalvular fibrillation treated anticoagulants. Of these patients, 75 had COPD (experimental group) — HF without comorbidities (comparison...

Background.Comorbid heart failure (HF) is common in chronic obstructive pulmonary disease (COPD). Comorbid condition features are studied well COPD due to tobacco smoke. There a lack of data about mechanisms, clinical and functional specificity occupational HF comorbidity. As share symptoms sometimes lung function disorders, there an unmet need new markers COPD.Aims establish molecular associated with comorbidity.Methods.Subjects were enrolled single-center prospective cohort observational...

Introduction. Heart failure increases the severity of symptoms and worsens prognosis chronic obstructive pulmonary disease (COPD) in smokers. Professional COPD is a separate phenotype, which suggests dif erences pat ern comorbidity. combination with heart has not been studied enough. T e aim study was to determine relationship c clinical, functional hygienic characteristics professional COPD. Materials methods. one-center observational included 115 patients occupational (OCOPD). comparison...

Occupational chronic obstructive pulmonary disease (COPD) patients with (n=44) or without (n=52) biventricular heart failure (HF) were investigated. Comparison groups COPD in tobacco smokers (n=38) (n=65) HF. Comorbid pathology was characterized by the highest levels of anxiety and depression (HADS-A score 7.4+0.86, HADS-D 7.9+0.75) associated serum S100В.

Aim Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are a common comorbidity. Professional (PCOPD) is specific phenotype, which suggests peculiarities in the development of HF. Difficulties HF diagnosis such patients determine relevance searching for additional markers. The aim study was identifying markers with PCOPD.Material methods This single-site, cohort, prospective, observational included 345 patients. main group consisted PCOPD patients; comparison COPD induced by...

Abstract Background Heart failure decompensation requiring hospitalization is an important event, associated with mortality and investigating its predictors topical problem. Chronic obstructive pulmonary disease (COPD) a common comorbidity for heart failure. Both conditions share molecular mechanisms such as systemic inflammation. COPD heterogeneous subpopulations different inflammation patterns may interact in manner. Airway occupational differs from tobacco smokers. Additionally...

Introduction. Brain metastases can occur in almost all gynecological malignancies and, despite modern therapeutic options, have a poor prognosis. from vulvar cancer are considered to be rare. In the literature, reports on these cases identity character. The aim is show clinical observation of patient with brain metastases. Results. Patient S., 60 years old, stage I р T1N0M0 underwent vulvectomy January 2018. During histological study subepithelial layers were areas kraurosis growth squamous...

<b>Background:</b> Nanoscale particles presenting in industrial aerosols modifies inflammation pattern and COPD phenotype including exacerbations. Impact of COVID-19 on subsequent exacerbations patients with occupational due to containing nanoparticles is unknown. <b>Objective:</b> To establish phenotypes subjects exposed recovered from COVID-19. <b>Methods:</b> Subjects (GOLD criteria), n=50, tobacco smokers COPD, n=50 were enrolled observational prospective study. Propensity score matching...